Calcineurin.

PubWeight™: 2.43‹?› | Rank: Top 2%

🔗 View Article (PMID 2833077)

Published in Adv Enzymol Relat Areas Mol Biol on January 01, 1988

Authors

C B Klee1, G F Draetta, M J Hubbard

Author Affiliations

1: Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892.

Articles citing this

Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes Dev (1997) 3.40

Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol (1995) 3.27

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc Natl Acad Sci U S A (1991) 3.02

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J (1993) 2.92

Molecular characterization of functional domains in the protein kinase SOS2 that is required for plant salt tolerance. Plant Cell (2001) 2.86

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone. Mol Cell Biol (1992) 2.80

Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals. Proc Natl Acad Sci U S A (1999) 2.42

Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells. Proc Natl Acad Sci U S A (1993) 2.39

Novel protein kinases associated with calcineurin B-like calcium sensors in Arabidopsis. Plant Cell (1999) 2.02

Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate. EMBO J (1998) 2.01

Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol Genomics (2006) 1.88

The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane. EMBO J (1995) 1.79

Light-regulated modification and nuclear translocation of cytosolic G-box binding factors in parsley. Plant Cell (1994) 1.78

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells. J Cell Biol (1995) 1.55

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. Proc Natl Acad Sci U S A (1989) 1.52

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. Proc Natl Acad Sci U S A (1996) 1.47

Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin. Mol Cell Biol (2000) 1.40

The SOS3 family of calcium sensors and SOS2 family of protein kinases in Arabidopsis. Plant Physiol (2004) 1.36

Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.33

Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans. Mol Biol Cell (2002) 1.32

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. J Exp Med (1992) 1.27

Regulation of organelle transport in melanophores by calcineurin. J Cell Biol (1990) 1.23

Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clin Microbiol Rev (1999) 1.21

Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin. Proc Natl Acad Sci U S A (1995) 1.18

Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1. Genetics (1998) 1.18

On the role of G protein activation and phosphorylation in desensitization to acetylcholine in guinea-pig atrial cells. J Physiol (1993) 1.17

Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A (2005) 1.16

Calcium-mediated modulation of N-methyl-D-aspartate (NMDA) responses in cultured rat hippocampal neurones. J Physiol (1993) 1.13

Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity. Mol Biol Cell (1993) 1.12

Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p. J Cell Biol (2001) 1.09

Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. Biochem J (2002) 1.07

Calcineurin regulates ryanodine receptor/Ca(2+)-release channels in rat heart. Biochem J (2000) 1.00

NFAT and NFkappaB activation in T lymphocytes: a model of differential activation of gene expression. Ann Biomed Eng (2006) 0.99

Presynaptic modulation of cortical synaptic activity by calcineurin. Proc Natl Acad Sci U S A (1995) 0.99

A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity. PLoS Comput Biol (2010) 0.98

The transmembrane signaling pathway involved in directed movements of Chlamydomonas flagellar membrane glycoproteins involves the dephosphorylation of a 60-kD phosphoprotein that binds to the major flagellar membrane glycoprotein. J Cell Biol (1994) 0.94

Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation. Immunol Rev (2009) 0.93

Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A. Proc Natl Acad Sci U S A (1993) 0.93

The EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent manner. Mol Biol Cell (1999) 0.92

Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. J Exp Med (2001) 0.91

Calcineurin homologous protein: a multifunctional Ca2+-binding protein family. Am J Physiol Renal Physiol (2011) 0.91

Stereospecific oxidation of calmodulin by methionine sulfoxide reductase A. Free Radic Biol Med (2013) 0.90

Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle. Biophys J (2002) 0.88

Calcineurin inhibition and new-onset diabetes mellitus after transplantation. Transplantation (2013) 0.87

Recognition of β-calcineurin by the domains of calmodulin: thermodynamic and structural evidence for distinct roles. Proteins (2010) 0.86

PP2B/calcineurin-mediated desensitization of TRPV1 does not require AKAP150. Biochem J (2010) 0.85

Regulation of ATP-induced calcium release in COS-7 cells by calcineurin. Biochem J (2000) 0.84

The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response. Curr Signal Transduct Ther (2009) 0.83

Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: a pilot study. J Mol Histol (2011) 0.82

Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Biochem J (2007) 0.82

uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in glioma. J Neurooncol (2011) 0.81

Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L-type voltage-gated calcium channels in the retina. J Cell Biochem (2012) 0.81

PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells. Mol Biol Cell (2007) 0.81

Mechanisms regulating resistance to inhibitors of topoisomerase II. Front Pharmacol (2013) 0.80

The activity of calmodulin is altered by phosphorylation: modulation of calmodulin function by the site of phosphate incorporation. Biochem J (1995) 0.80

Global analysis of serine/threonine and tyrosine protein phosphatase catalytic subunit genes in Neurospora crassa reveals interplay between phosphatases and the p38 mitogen-activated protein kinase. G3 (Bethesda) (2014) 0.80

Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines. J Biol Chem (2013) 0.79

What is left when anti-tumour necrosis factor therapy in inflammatory bowel diseases fails? World J Gastroenterol (2014) 0.79

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy. Mol Cell Biol (2012) 0.79

The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway. J Biol Chem (2011) 0.79

T-cell stimulation through the T-cell receptor/CD3 complex regulates CD2 lateral mobility by a calcium/calmodulin-dependent mechanism. Biophys J (1999) 0.77

Protein phosphatases in pancreatic islets. J Endocrinol (2014) 0.77

The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum and its possible involvement in development. Eukaryot Cell (2004) 0.77

Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila. Genetics (2014) 0.76

AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal (2015) 0.76

Role of calcineurin in thrombin-mediated endothelial cell contraction. Cytometry A (2009) 0.75

La3+ stimulate the activity of calcineurin in two different ways. J Biol Inorg Chem (2005) 0.75

Preliminary crystallization studies of calmodulin-dependent protein phosphatase (calcineurin) from bovine brain. Mol Cell Biochem (1996) 0.75

Putting a brake on synaptic vesicle endocytosis. Cell Mol Life Sci (2017) 0.75

The unique C-terminus of calcineurin isoform CNAβ1 confers non-canonical regulation of enzyme activity by Ca(2+) and calmodulin. J Biol Chem (2017) 0.75

Articles by these authors

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science (1995) 9.79

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med (1997) 5.10

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07

Parasexual genetic analysis of Candida albicans by spheroplast fusion. J Bacteriol (1981) 2.65

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J (2001) 2.45

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev (1994) 2.39

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene (1994) 2.18

Ca2+-dependent phospholipid- (and membrane-) binding proteins. Biochemistry (1988) 1.86

UBPY: a growth-regulated human ubiquitin isopeptidase. EMBO J (1998) 1.76

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep (2000) 1.72

Interaction between Cdc37 and Cdk4 in human cells. Oncogene (1997) 1.25

Isolation and morphological characterization of a mycelial mutant of Candida albicans. J Bacteriol (1986) 1.23

Proteasome-dependent degradation of p27/kip1 in gliomas. J Neuropathol Exp Neurol (1999) 1.19

Molecular cloning of ERp29, a novel and widely expressed resident of the endoplasmic reticulum. FEBS Lett (1997) 1.01

Genetically engineered calmodulins differentially activate target enzymes. J Biol Chem (1986) 0.98

New paradigms on the transport functions of maturation-stage ameloblasts. J Dent Res (2012) 0.97

Characterization of a tetraploid derivative of Candida albicans ATCC 10261. J Bacteriol (1985) 0.97

Partial structure and hormonal regulation of rabbit liver inhibitor-1; distribution of inhibitor-1 and inhibitor-2 in rabbit and rat tissues. Biochim Biophys Acta (1989) 0.92

Multisite phosphorylation of the glycogen-binding subunit of protein phosphatase-1G by cyclic AMP-dependent protein kinase and glycogen synthase kinase-3. FEBS Lett (1989) 0.92

Do porins inhibit the macrophage phagocyting activity by stimulating the adenylate cyclase? J Cyclic Nucleotide Protein Phosphor Res (1986) 0.89

The effect of acrylic cement on the union of internally fixed experimental fractures of the femoral shaft in the rabbit. Injury (1980) 0.89

Targeting subunits for protein phosphatases. Methods Enzymol (1991) 0.86

Lysozyme and alpha-lactalbumin from the milk of a marsupial, the common brush-tailed possum (Trichosurus vulpecula). Biochim Biophys Acta (1997) 0.83

The isolation of plasma membrane and characterisation of the plasma membrane ATPase from the yeast Candida albicans. Eur J Biochem (1986) 0.83

Endoplasmic reticulum Ca2+-ATPase pump is up-regulated in calcium-transporting dental enamel cells: a non-housekeeping role for SERCA2b. Biochem J (2001) 0.82

The measurement of progression in protrusio acetabuli. Am J Roentgenol Radium Ther Nucl Med (1969) 0.81

Morphological studies of N-acetylglucosamine induced germ tube formation by Candida albicans. Can J Microbiol (1985) 0.81

Correlated light and scanning electron microscopy of artificial carious lesions. J Dent Res (1982) 0.81

Surface integrity governs the proteome of hypomineralized enamel. J Dent Res (2010) 0.80

The treatment of femoral shaft fractures in the elderly. J Bone Joint Surg Br (1974) 0.79

The phosphorylation of calmodulin and calmodulin fragments by kinase fractions from bovine brain. Biochim Biophys Acta (1988) 0.79

Are matrix vesicles apoptotic bodies? Prog Clin Biol Res (1982) 0.79

The fixation of experimental femoral shaft torque fractures. Acta Orthop Scand (1973) 0.79

Calbindin28kDa is specifically associated with extranuclear constituents of the dense particulate fraction. Cell Tissue Res (2000) 0.78

Wrist joint arthroplasty in rheumatoid arthritis: a comparison between the Meuli and Swanson prostheses. J Hand Surg Br (1984) 0.78

Scanning electron microscopy of trypsin-treated enamel from fluorosed rat molars. Adv Dent Res (1989) 0.77

The effects of polyamines on the cyclic AMP efflux and metabolism in E. coli B cells. Int J Biochem (1981) 0.77

The kinetics and divalent cation inhibition of plasma membrane ATPase in the yeast Candida albicans. J Biol Chem (1985) 0.77

Multiple forms of calcineurin, a brain isozyme of the calmodulin-stimulated protein phosphatase. Adv Second Messenger Phosphoprotein Res (1990) 0.76

Relationship between the fluidity of the membrane lipids and the activity of the membrane-bound proteins: the effects of lidocaine on the adenylate cyclase activity of rat myocardium. Gen Pharmacol (1983) 0.75

Altered free calcium transients in pig kidney cells (LLC-PK1) cultured with penicillin/streptomycin. In Vitro Cell Dev Biol Anim (1994) 0.75

Rapid dissection of rodent molar-tooth germs. Lab Anim (1981) 0.75

Different modes of interaction of calmodulin with its target enzymes. J Cardiovasc Pharmacol (1986) 0.75

Torsion of the omentum. Br J Clin Pract (1969) 0.75

Inhibition of adenylate cyclase by transglutaminase-catalyzed reactions in pigeon erythrocyte ghosts. Biochem Biophys Res Commun (1986) 0.75

The place of articulated lower limb prosthesis in Uganda today. East Afr Med J (1973) 0.75

Fractures of the femoral shaft. The advantages of internal fixation and problems after skeletal traction. J R Coll Surg Edinb (1987) 0.75

The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium. Gen Pharmacol (1985) 0.75

A prospective controlled trial of valgus osteotomy in the fixation of unstable pertrochanteric fractures of the femur. Injury (1980) 0.75

Organ culture of murine tooth germs exposed to alloimmune IgG. J Dent Res (1981) 0.75

Calmodulin-like activity in a mineralising tissue: the rat molar tooth germ. Calcif Tissue Int (1981) 0.75

A controlled trial of cloxacillin and tetracycline in chronic staphylococcal osteomyelitis in Ugandan children. East Afr Med J (1973) 0.75