Published in Cell Death Differ on March 03, 2017
Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66
Non-canonical inflammasome activation targets caspase-11. Nature (2011) 8.85
Pyroptosis: host cell death and inflammation. Nat Rev Microbiol (2009) 7.63
Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science (2013) 5.06
Inflammatory caspases are innate immune receptors for intracellular LPS. Nature (2014) 4.88
Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science (2013) 3.56
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol (2006) 3.44
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature (2015) 2.71
Pore-forming activity and structural autoinhibition of the gasdermin family. Nature (2016) 2.71
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature (2015) 2.67
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ (2009) 2.33
Nonsyndromic hearing impairment is associated with a mutation in DFNA5. Nat Genet (1998) 1.63
Secondary necrosis: the natural outcome of the complete apoptotic program. FEBS Lett (2010) 1.57
Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochem J (2015) 1.56
Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci (2005) 1.53
Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. FASEB J (2000) 1.48
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature (2016) 1.44
Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications. Apoptosis (2008) 1.42
Pyroptotic cell death defends against intracellular pathogens. Immunol Rev (2015) 1.40
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res (2015) 1.37
Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics (2007) 1.34
Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol (2016) 1.27
Host defense peptides: front-line immunomodulators. Trends Immunol (2014) 1.26
A 3-nucleotide deletion in the polypyrimidine tract of intron 7 of the DFNA5 gene causes nonsyndromic hearing impairment in a Chinese family. Genomics (2003) 1.22
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc Natl Acad Sci U S A (2016) 1.21
GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene (2007) 1.21
Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer (2009) 1.18
Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol (2011) 1.17
Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. Cancer Sci (2007) 1.14
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J (2016) 1.13
A novel mutation identified in the DFNA5 gene in a Dutch family: a clinical and genetic evaluation. Audiol Neurootol (2003) 1.12
Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer. Biochem Biophys Res Commun (2008) 1.05
Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma. Oncogene (2008) 1.05
A novel DFNA5 mutation, IVS8+4 A>G, in the splice donor site of intron 8 causes late-onset non-syndromic hearing loss in a Chinese family. Clin Genet (2007) 1.03
DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells. FEBS Lett (2001) 1.03
The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein. Eur J Hum Genet (2011) 1.03
PINK1/Parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol (2015) 1.02
The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage. J Hum Genet (2006) 1.01
Evidence for a founder mutation causing DFNA5 hearing loss in East Asians. J Hum Genet (2009) 0.98
A yeast model for the study of human DFNA5, a gene mutated in nonsyndromic hearing impairment. Biochim Biophys Acta (2003) 0.96
Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. G3 (Bethesda) (2013) 0.95
Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. Pediatr Pulmonol (2011) 0.95
DFNA5: hearing impairment exon instead of hearing impairment gene? J Med Genet (2004) 0.93
Gsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes. Histochem Cell Biol (2012) 0.92
Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res (2016) 0.92
Gsdma3 gene is needed for the induction of apoptosis-driven catagen during mouse hair follicle cycle. Histochem Cell Biol (2011) 0.88
Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB). Genes Genet Syst (2010) 0.88
The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways. Front Cell Neurosci (2015) 0.86
The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae. Front Oncol (2012) 0.86
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun (2017) 0.84
Profiling of Parkin-binding partners using tandem affinity purification. PLoS One (2013) 0.84
Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus. Hum Mol Genet (2014) 0.84
A novel splice site mutation in DFNA5 causes late-onset progressive non-syndromic hearing loss in a Chinese family. Int J Pediatr Otorhinolaryngol (2014) 0.84
Tom70 is essential for PINK1 import into mitochondria. PLoS One (2013) 0.84
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol (2016) 0.82
The expression and regulation of DFNA5 in human hepatocellular carcinoma DFNA5 in hepatocellular carcinoma. Mol Biol Rep (2013) 0.79
N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting. J Biomed Sci (2015) 0.78
Association Between Gasdermin A and Gasdermin B Polymorphisms and Susceptibility to Adult and Childhood Asthma Among Jordanians. Genet Test Mol Biomarkers (2016) 0.76
Antizyme inhibitor 1: a potential carcinogenic molecule. Cancer Sci (2016) 0.75
E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. J Cancer (2017) 0.75