A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen.

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Published in J Virol on July 01, 1988

Authors

J M Hardwick1, P M Lieberman, S D Hayward

Author Affiliations

1: Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical School, Baltimore, Maryland 21205.

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Stimulation of CREB binding protein nucleosomal histone acetyltransferase activity by a class of transcriptional activators. Mol Cell Biol (2001) 1.45

Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial. Mol Cell Biol (1995) 1.45

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene. Proc Natl Acad Sci U S A (1992) 1.39

Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors. J Virol (2001) 1.39

Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol Cell Biol (2001) 1.31

The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins. J Virol (1998) 1.31

Epstein-Barr virus (P3HR-1) defective DNA codes for components of both the early antigen and viral capsid antigen complexes. Virology (1984) 1.27

A human TATA binding protein-related protein with altered DNA binding specificity inhibits transcription from multiple promoters and activators. Mol Cell Biol (1999) 1.27

The Epstein-Barr virus latency BamHI-Q promoter is positively regulated by STATs and Zta interference with JAK/STAT activation leads to loss of BamHI-Q promoter activity. Proc Natl Acad Sci U S A (1999) 1.27

Expression of Epstein-Barr virus BamHI-A rightward transcripts in latently infected B cells from peripheral blood. Blood (1999) 1.24

The amino-terminal C/H1 domain of CREB binding protein mediates zta transcriptional activation of latent Epstein-Barr virus. Mol Cell Biol (1999) 1.22

Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant human EBV/C3d receptor. Proc Natl Acad Sci U S A (1988) 1.14

The vector homology problem in diagnostic nucleic acid hybridization of clinical specimens. J Clin Microbiol (1986) 1.13

Interaction with the Epstein-Barr virus helicase targets Zta to DNA replication compartments. J Virol (2001) 1.09

The transcriptional corepressor DSP1 inhibits activated transcription by disrupting TFIIA-TBP complex formation. EMBO J (1996) 1.07

Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae. Mol Cell Biol (1998) 1.07

An imperfect correlation between DNA replication activity of Epstein-Barr virus nuclear antigen 1 (EBNA1) and binding to the nuclear import receptor, Rch1/importin alpha. Virology (1997) 1.05

Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding. J Biol Chem (1998) 1.02

Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. J Virol (2001) 1.01

The lytic origin of herpesvirus papio is highly homologous to Epstein-Barr virus ori-Lyt: evolutionary conservation of transcriptional activation and replication signals. J Virol (1993) 1.00

Properties of two EBV Mta nuclear export signal sequences. Virology (2001) 0.99

Detection of Epstein-Barr virus DNA in mouthwashes by hybridization. J Clin Microbiol (1985) 0.99

The chromosome of bacteriophage T5. 3. Patterns of transcription from the single-stranded DNA fragments. J Mol Biol (1973) 0.99

Identification of acidic and aromatic residues in the Zta activation domain essential for Epstein-Barr virus reactivation. J Virol (2001) 0.98

A testis-specific transcription factor IIA (TFIIAtau) stimulates TATA-binding protein-DNA binding and transcription activation. J Biol Chem (2000) 0.97

Lytic viral replication as a contributor to the detection of Epstein-Barr virus in breast cancer. J Virol (2003) 0.95

Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF. Mol Cell Biol (1996) 0.93

Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. J Biol Chem (1996) 0.91

Enzyme-linked immunosorbent assay of antibodies to Epstein-Barr virus nuclear and early antigens in patients with infectious mononucleosis and nasopharyngeal carcinoma. Ann Intern Med (1986) 0.91

Binding of EBNA-1 to DNA creates a protease-resistant domain that encompasses the DNA recognition and dimerization functions. J Virol (1992) 0.89

Phosphorylation of TFIIA stimulates TATA binding protein-TATA interaction and contributes to maximal transcription and viability in yeast. Mol Cell Biol (1999) 0.87

Oligonucleotides for polymerase chain reaction amplification and hybridization detection of Epstein-Barr virus DNA in clinical specimens. Mol Cell Probes (1990) 0.84

Structural organization of human herpesvirus DNA molecules. J Invest Dermatol (1984) 0.84

Functional analysis of TFIID-activator interaction by magnesium-agarose gel electrophoresis. Methods (1997) 0.82

Delineation of a 16 amino acid sequence that forms a core DNA recognition motif in the Epstein-Barr virus EBNA-1 protein. Virology (1994) 0.80

Possible involvement of the mouse Grg protein in transcription. Cell Mol Biol Res (1995) 0.79

Analysis of the DNA OF Epstein-Barr viruses and transcriptional products in transformed cells. IARC Sci Publ (1975) 0.79

CD4+ and CD8+ T-cell responses to latent antigen EBNA-1 and lytic antigen BZLF-1 during persistent lymphocryptovirus infection of rhesus macaques. J Virol (2013) 0.79

In situ detection of lytic Epstein-Barr virus infection: expression of the NotI early gene and viral interleukin-10 late gene in clinical specimens. J Infect Dis (1993) 0.78

Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. J Biol Chem (2001) 0.78

Adenovirus-based vaccines against rhesus lymphocryptovirus EBNA-1 induce expansion of specific CD8+ and CD4+ T cells in persistently infected rhesus macaques. J Virol (2014) 0.78

Association of Epstein-Barr virus with primary central nervous system lymphoma in AIDS. AIDS Res Hum Retroviruses (1992) 0.75

Identification of transactivation, repression, and protein-protein interaction domains using GAL4-fusion proteins. Methods Mol Biol (2001) 0.75