Published in Elife on April 12, 2017
Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron (2003) 6.19
Synaptic plasticity and addiction. Nat Rev Neurosci (2007) 6.08
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron (2008) 5.65
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature (2001) 5.65
Input-specific control of reward and aversion in the ventral tegmental area. Nature (2012) 4.60
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron (2011) 3.89
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci (2003) 3.64
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn Schmiedebergs Arch Pharmacol (2002) 2.97
Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neurosci (2004) 2.87
GABA neurons of the VTA drive conditioned place aversion. Neuron (2012) 2.86
Activation of VTA GABA neurons disrupts reward consumption. Neuron (2012) 2.80
Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J Neurosci (2006) 2.80
Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron (2008) 2.69
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res (2009) 2.61
Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A (2006) 2.29
Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J Neurosci (2003) 2.21
The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl) (2010) 2.19
Opioids block long-term potentiation of inhibitory synapses. Nature (2007) 1.94
Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. J Biol Chem (2007) 1.91
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science (2013) 1.91
Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology (Berl) (2010) 1.90
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc Natl Acad Sci U S A (2009) 1.88
Orexin (hypocretin) neurons contain dynorphin. J Neurosci (2001) 1.84
Stress reinstates heroin-seeking in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology (Berl) (1995) 1.82
Are you or aren't you? Challenges associated with physiologically identifying dopamine neurons. Trends Neurosci (2012) 1.78
Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology (Berl) (2008) 1.68
Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proc Natl Acad Sci U S A (2010) 1.63
Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons. J Neurophysiol (2004) 1.62
In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J Pharmacol Exp Ther (2005) 1.54
Role of kappa-opioid receptors in stress and anxiety-related behavior. Psychopharmacology (Berl) (2013) 1.53
Nor-binaltorphimine: a potent and selective kappa-opioid receptor antagonist with long-lasting activity in vivo. Arch Int Pharmacodyn Ther (1992) 1.51
Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Res (1990) 1.51
Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J Biol Chem (2003) 1.45
Social stress increases the acquisition of cocaine self-administration in male and female rats. Brain Res (1995) 1.36
Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sci (2004) 1.35
Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. J Neurosci (2010) 1.32
Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence. J Pharmacol Exp Ther (2003) 1.32
Synaptic inputs to GABAA and GABAB receptors originate from discrete afferent neurons. Neurosci Lett (1992) 1.30
Non-contingent electric footshock facilitates the acquisition of intravenous cocaine self-administration in rats. Psychopharmacology (Berl) (1994) 1.29
Dopamine D1 receptors facilitate transmitter release. Nature (1993) 1.27
Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol Pharmacol (2001) 1.24
Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci (1994) 1.20
Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation. Mol Pharmacol (2011) 1.20
Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress. Neuropsychopharmacology (2015) 1.17
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment. J Pharmacol Exp Ther (2007) 1.16
Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics. Methods Mol Biol (2014) 1.14
Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats. Psychopharmacology (Berl) (1994) 1.11
Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area. Eur J Neurosci (2010) 1.11
Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity. Biol Psychiatry (2011) 1.10
Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area. Proc Natl Acad Sci U S A (2014) 1.08
Safety, tolerability, and clinical effect of low-dose buprenorphine for treatment-resistant depression in midlife and older adults. J Clin Psychiatry (2014) 1.08
Kappa opioid inhibition of somatodendritic dopamine inhibitory postsynaptic currents. J Neurophysiol (2006) 1.07
Ventral tegmental afferents in stress-induced reinstatement: the role of cAMP response element-binding protein. J Neurosci (2010) 1.06
Calmodulin binding to G protein-coupling domain of opioid receptors. J Biol Chem (1999) 1.05
PKG and PKA signaling in LTP at GABAergic synapses. Neuropsychopharmacology (2009) 1.02
Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library. J Biol Chem (1999) 1.00
Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity. Neuron (2013) 0.99
Stress and VTA synapses: implications for addiction and depression. Eur J Neurosci (2014) 0.99
LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders. Neuropharmacology (2013) 0.99
Reinstatement of heroin-reinforced behavior following long-term extinction: implications for the treatment of relapse to drug taking. Behav Pharmacol (1994) 0.96
Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice. Neuropsychopharmacology (2006) 0.95
Persistent increases in cocaine-seeking behavior after acute exposure to cold swim stress. Biol Psychiatry (2010) 0.95
Orexin/hypocretin role in reward: implications for opioid and other addictions. Br J Pharmacol (2014) 0.92
Evaluation of opioid modulation in major depressive disorder. Neuropsychopharmacology (2014) 0.92
Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats. Biol Psychiatry (2013) 0.90
Emotional but not physical stress enhances intravenous cocaine self-administration in drug-naive rats. Brain Res (1993) 0.90
Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area. J Neurosci (2012) 0.88
Poststress block of kappa opioid receptors rescues long-term potentiation of inhibitory synapses and prevents reinstatement of cocaine seeking. Biol Psychiatry (2014) 0.88
Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.87
The vital role of constitutive GPCR activity in the mesolimbic dopamine system. Transl Psychiatry (2014) 0.87
Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats. Synapse (2013) 0.86
Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell. J Neurochem (2000) 0.83
Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. J Neurosci (2015) 0.82
Persistent receptor activity underlies group I mGluR-mediated cellular plasticity in CA3 neuron. J Neurosci (2013) 0.81
Dynorphin, Dysphoria, and Dependence: the Stress of Addiction. Neuropsychopharmacology (2016) 0.80
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation. Mol Pharmacol (1996) 0.80
Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats. PLoS One (2012) 0.79
Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice. Neuropsychopharmacology (2016) 0.78
Buprenorphine + naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study. Addiction (2016) 0.78
Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior. Nat Neurosci (2017) 0.77
Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons. Cell Rep (2017) 0.76
Maturational alterations in constitutive activity of medial prefrontal cortex kappa-opioid receptors in Wistar rats. J Neurochem (2015) 0.76
Sustained-Release Buprenorphine (RBP-6000) Blocks the Effects of Opioid Challenge With Hydromorphone in Subjects With Opioid Use Disorder. J Clin Psychopharmacol (2016) 0.76
The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism. Cell Signal (2015) 0.76