Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.

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Published in PLoS Genet on April 20, 2017

Authors

Penelope J Boyd1,2, Wen-Yo Tu3, Hannah K Shorrock1,2, Ewout J N Groen1,2, Roderick N Carter4, Rachael A Powis1,2, Sophie R Thomson2, Derek Thomson2, Laura C Graham5, Anna A L Motyl2, Thomas M Wishart5, J Robin Highley3, Nicholas M Morton4, Thomas Becker1,6, Catherina G Becker1,6, Paul R Heath3, Thomas H Gillingwater7,8,9

Author Affiliations

1: Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom.
2: Centre for Integrative Physiology, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.
3: Sheffield Institute for Translation Neuroscience, University of Sheffield, Sheffield, United Kingdom.
4: University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queens Medical Research Institute, Edinburgh, United Kingdom.
5: Division of Neurobiology, Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
6: Centre for Neuroregeneration, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.
7: Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Old Medical School, Teviot Place, Edinburgh EH8 9XD, UK t.gillingwater@ed.ac.uk.
8: Centre for Integrative Physiology, University of Edinburgh, Old Medical School, Teviot Place, Edinburgh EH8 9XD, UK.
9: Anatomy, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Old Medical School, Teviot Place, Edinburgh EH8 9XD, UK.

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