PU.1 serves a critical role in the innate defense against Aspergillus fumigatus via dendritic cell-associated C-type lectin receptor-1 and toll-like receptors-2 and 4 in THP-1-derived macrophages.

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Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity (2010) 6.48

Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med (2008) 4.16

The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol (2004) 3.21

GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity (2001) 3.13

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis. Clin Microbiol Rev (2009) 3.10

Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates. Infect Immun (2003) 2.88

Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol (2009) 2.74

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Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annu Rev Physiol (2002) 2.23

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Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus. J Biol Chem (2002) 1.87

Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol (2003) 1.86

Aspergillus fumigatus: principles of pathogenesis and host defense. Eukaryot Cell (2007) 1.74

Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood (2010) 1.52

Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol (2004) 1.42

Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages. J Immunol (2002) 1.40

Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens. Infect Immun (2003) 1.11

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Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells. Eur J Clin Microbiol Infect Dis (2012) 1.07

Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes. Cell Microbiol (2004) 1.06

Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia. Blood (2011) 1.03

TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis. Med Mycol (2009) 1.00

The transcription factor PU.1 is a critical regulator of cellular communication in the immune system. Arch Immunol Ther Exp (Warsz) (2011) 0.99

Binding of live conidia of Aspergillus fumigatus activates in vitro-generated human Langerhans cells via a lectin of galactomannan specificity. Clin Exp Immunol (2003) 0.96

Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol (2012) 0.94

Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells. Blood (2010) 0.93

Antifungal innate immunity: recognition and inflammatory networks. Semin Immunopathol (2014) 0.91

Downregulation of PU.1 leads to decreased expression of Dectin-1 in alveolar macrophages during Pneumocystis pneumonia. Infect Immun (2010) 0.89

Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to increased tuberculosis susceptibility. PLoS Pathog (2014) 0.88

Interference of Aspergillus fumigatus with the immune response. Semin Immunopathol (2014) 0.87

The innate immune response to Aspergillus fumigatus at the alveolar surface. FEMS Microbiol Rev (2015) 0.86

Aspergillus fumigatus and related species. Cold Spring Harb Perspect Med (2014) 0.85

miR-15a/16 regulates macrophage phagocytosis after bacterial infection. J Immunol (2014) 0.84

Suppression of PU.1-linked TLR4 expression by cilostazol with decrease of cytokine production in macrophages from patients with rheumatoid arthritis. Br J Pharmacol (2013) 0.84

Why does the autoantibody against granulocyte-macrophage colony-stimulating factor cause lesions only in the lung? Respirology (2006) 0.82

Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1. Blood (2015) 0.79

An Adenoviral Vector Encoding Full-Length Dectin-1 Promotes Aspergillus-Induced Innate Immune Response in Macrophages. Lung (2015) 0.79

Activation of NF-κB and respiratory burst following Aspergillus fumigatus stimulation of macrophages. Immunobiology (2013) 0.78