HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28449718)

Published in J Exp Clin Cancer Res on April 27, 2017

Authors

Meili Wang1, Xiulan Zhao2,3, Dongwang Zhu4, Tieju Liu1,5, Xiaohui Liang5, Fang Liu1,5, Yanhui Zhang6, Xueyi Dong1,5, Baocun Sun7,8

Author Affiliations

1: Department of Pathology, Tianjin Medical University, Tianjin, 300070, China.
2: Department of Pathology, Tianjin Medical University, Tianjin, 300070, China. xiulanzhao@aliyun.com.
3: Department of Pathology, General Hospital of Tianjin Medical University, Tianjin, 300052, China. xiulanzhao@aliyun.com.
4: Department of Surgery, Stomatological Hospital of Tianjin Medical University, Tianjin, 300070, China.
5: Department of Pathology, General Hospital of Tianjin Medical University, Tianjin, 300052, China.
6: Department of Pathology, Cancer Hospital of Tianjin Medical University, Tianjin, 300060, China.
7: Department of Pathology, Tianjin Medical University, Tianjin, 300070, China. baocunsun@aliyun.com.
8: Department of Pathology, General Hospital of Tianjin Medical University, Tianjin, 300052, China. baocunsun@aliyun.com.

Articles cited by this

Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 28.01

Hypoxia-inducible factors in physiology and medicine. Cell (2012) 8.16

Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol (1999) 7.66

Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96

Cancer Statistics, 2017. CA Cancer J Clin (2017) 4.77

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. J Cell Biol (1995) 3.03

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene (2009) 2.86

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J (2005) 2.71

Oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med (2010) 2.45

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. Blood (2012) 2.35

Properties and function of lysyl oxidase. Am J Respir Cell Mol Biol (1991) 2.25

CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Cell Motil Cytoskeleton (1993) 1.99

Lysyl oxidase: properties, regulation and multiple functions in biology. Matrix Biol (1998) 1.93

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res (2009) 1.60

The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem (2009) 1.56

ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res (2010) 1.43

Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: a study of hepatocellular carcinoma. Hepatology (2011) 1.31

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia. Cancer Lett (2012) 1.30

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas. EMBO Mol Med (2011) 1.28

Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma. Gynecol Oncol (2014) 1.24

Cenp-F (mitosin) is more than a mitotic marker. Chromosoma (2006) 1.20

A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion. BMC Cancer (2009) 1.13

The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res (2008) 1.08

Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF. Leukemia (2004) 1.01

Role of epithelial to mesenchymal transition in hepatocellular carcinoma. J Hepatol (2016) 1.00

Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer. Br J Cancer (2015) 0.99

LOXL2 in epithelial cell plasticity and tumor progression. Future Oncol (2012) 0.96

MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. J Biol Chem (2013) 0.94

Malignant genome reprogramming by ATAD2. Biochim Biophys Acta (2013) 0.94

miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis. BMC Cancer (2014) 0.94

Epithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumors. Oncotarget (2017) 0.93

The proliferation, apoptosis, invasion of endothelial-like epithelial ovarian cancer cells induced by hypoxia. J Exp Clin Cancer Res (2010) 0.93

Downregulation of L1CAM inhibits proliferation, invasion and arrests cell cycle progression in pancreatic cancer cells in vitro. Exp Ther Med (2014) 0.89

Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha. Leukemia (2005) 0.89

Prognostic relevance and therapeutic implications of centromere protein F expression in patients with esophageal squamous cell carcinoma. Dis Esophagus (2012) 0.87

LOXL2 status correlates with tumor stage and regulates integrin levels to promote tumor progression in ccRCC. Mol Cancer Res (2014) 0.86

Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer. Cancer Lett (2014) 0.86

Hypoxia-induced vasculogenic mimicry formation via VE-cadherin regulation by Bcl-2. Med Oncol (2012) 0.85

Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. Eur J Cancer (2008) 0.84

ATAD2 is highly expressed in ovarian carcinomas and indicates poor prognosis. Asian Pac J Cancer Prev (2014) 0.83

ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis. Dev Growth Differ (2010) 0.81

Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma. Biochem Biophys Res Commun (2013) 0.80

ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker. Clin Transl Oncol (2015) 0.80

Centromere protein F and survivin are associated with high risk and a poor prognosis in colorectal gastrointestinal stromal tumours. J Clin Pathol (2011) 0.79

The hypoxia-related signaling pathways of vasculogenic mimicry in tumor treatment. Biomed Pharmacother (2016) 0.79

Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer. Oncol Rep (2015) 0.78

Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling. Oncotarget (2015) 0.78

Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer. Int J Mol Med (2015) 0.78

Emerging role of LOXL2 in the promotion of pancreas cancer metastasis. Oncotarget (2016) 0.77

Hypoxia induced epithelial-mesenchymal transition and vasculogenic mimicry formation by promoting Bcl-2/Twist1 cooperation. Exp Mol Pathol (2015) 0.76