An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28570148)

Published in Ann Am Thorac Soc on June 01, 2017

Authors

Benjamin T Suratt, Niki D J Ubags, Deepa Rastogi, Kelan G Tantisira, Benjamin J Marsland, Irina Petrache, Janice B Allen, Jason H T Bates, Fernando Holguin, Meredith C McCormack, Evangelos D Michelakis, Stephen M Black, Manu Jain, Ana L Mora, Viswanathan Natarajan, Yury I Miller, Michael B Fessler, Konstantin G Birukov, Ross S Summer, Stephanie A Shore, Anne E Dixon, Allergy, Immunology, and Inflammation Assembly

Articles by these authors

Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation (2010) 19.30

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell (2007) 9.20

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32

Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol (2005) 4.57

Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med (2005) 4.31

Innate and acquired immunity in atherogenesis. Nat Med (2002) 4.22

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science (2009) 3.90

Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation (2007) 3.33

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation (2006) 3.21

Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med (2008) 3.19

Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation (2005) 3.00

Counterpoint: release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are not the main effectors for full and sustained HPV. J Appl Physiol (1985) (2007) 2.98

Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol (2007) 2.88

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax (2011) 2.84

Endothelin axis is upregulated in human and rat right ventricular hypertrophy. Circ Res (2012) 2.83

Retracted G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C. J Biol Chem (2010) 2.81

Use of sildenafil for safe improvement of erectile function and quality of life in men with New York Heart Association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial. Arch Intern Med (2004) 2.78

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest (2009) 2.75

Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension. N Engl J Med (2009) 2.64

A reevaluation of the validity of unrestrained plethysmography in mice. J Appl Physiol (1985) (2002) 2.63

Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype. Am J Respir Crit Care Med (2005) 2.56

Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med (2011) 2.45

Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol (2011) 2.44

Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. J Biol Chem (2004) 2.44

The allergic mouse model of asthma: normal smooth muscle in an abnormal lung? J Appl Physiol (1985) (2003) 2.44

Hypoxic pulmonary vasoconstriction. J Appl Physiol (1985) (2005) 2.38

Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest (2007) 2.37

Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest (2005) 2.32

Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28

Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. Am J Pathol (2006) 2.25

Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med (2011) 2.24

Clinical significance of microbial infection and adaptation in cystic fibrosis. Clin Microbiol Rev (2011) 2.23

Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 2.18

Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation (2009) 2.17

Airway hyperresponsiveness in allergically inflamed mice: the role of airway closure. Am J Respir Crit Care Med (2007) 2.16

Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset. Thorax (2012) 2.14

Measuring the lung function in the mouse: the challenge of size. Respir Res (2003) 2.14

TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses. J Immunol (2007) 2.11

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10

Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med (2004) 2.10

Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res (2004) 2.06

An official American Thoracic Society Workshop report: obesity and asthma. Proc Am Thorac Soc (2010) 2.05

Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal (2010) 2.04

Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension. Sci Transl Med (2010) 2.04

Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res (2009) 2.03

Peak pressures during manual ventilation. Respir Care (2005) 2.03

Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells. Am J Respir Crit Care Med (2005) 2.01

Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res (2003) 2.01

Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med (2003) 1.98

Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res (2008) 1.98

Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98

Relation between objective measures of atopy and myocardial infarction in the United States. J Allergy Clin Immunol (2012) 1.98

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95

17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med (2012) 1.95

Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol (2010) 1.94

Acute health effects after exposure to chlorine gas released after a train derailment. Am J Emerg Med (2009) 1.94

The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A (2007) 1.93

Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations. J Appl Physiol (1985) (2002) 1.92

Extreme obesity and outcomes in critically ill patients. Chest (2011) 1.92

Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren. Environ Health Perspect (2008) 1.92

The role of time and pressure on alveolar recruitment. J Appl Physiol (1985) (2008) 1.92

Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses. Am J Physiol Lung Cell Mol Physiol (2004) 1.91

Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res (2009) 1.89

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88

Transcriptomic analysis of human lung development. Am J Respir Crit Care Med (2009) 1.87

Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem Pharmacol (2009) 1.85

Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest (2012) 1.85

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Am J Respir Crit Care Med (2010) 1.84

Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res (2007) 1.83

Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol (2003) 1.82

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res (2010) 1.82

GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2005) 1.81

Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter. Am J Respir Crit Care Med (2005) 1.81

Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem (2007) 1.80

IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood (2006) 1.79

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79

S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity. Proc Natl Acad Sci U S A (2004) 1.79

Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils. Infect Immun (2005) 1.79

Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem (2009) 1.78

The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation. Crit Care Med (2010) 1.78

Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal Biochem (2005) 1.77

An evidence-based approach to the management of pulmonary arterial hypertension. Curr Opin Cardiol (2006) 1.76

Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med (2011) 1.76

State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc (2006) 1.75

The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest (2010) 1.75

Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J Biol Chem (2007) 1.74

High IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest (2015) 1.74

Measurement of local permeability at subcellular level in cell models of agonist- and ventilator-induced lung injury. Lab Invest (2012) 1.74

Focal adhesions: paradigm for a signaling nexus. Circ Res (2006) 1.73

Cross-neutralization of four paramyxoviruses by a human monoclonal antibody. Nature (2013) 1.73

Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness. J Clin Invest (2004) 1.70

Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med (2010) 1.67