The Transcription Factor EB Links Cellular Stress to the Immune Response

.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28656016)

Published in Yale J Biol Med on June 23, 2017

Authors

Neel R Nabar1,2, John H Kehrl1

Author Affiliations

1: B cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institutes of Allergy and Infection Disease, National Institutes of Health, Bethesda, MD.
2: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.

Articles cited by this

(truncated to the top 100)

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J (1955) 38.61

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11

Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature (2009) 13.23

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell (2004) 12.71

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24

Autophagy in immunity and inflammation. Nature (2011) 11.16

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature (2009) 10.83

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87

The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol (2006) 7.98

A gene network regulating lysosomal biogenesis and function. Science (2009) 7.17

Innate immunity. N Engl J Med (2000) 7.03

TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif. Genes Dev (1990) 6.00

Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71

Protein kinase C: structure, function, and regulation. J Biol Chem (1995) 5.55

Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell (2001) 5.12

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell (1993) 5.00

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol (2012) 4.72

The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol (2009) 4.53

Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16

Cross-presentation by dendritic cells. Nat Rev Immunol (2012) 3.95

Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet (2004) 3.78

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy (2010) 3.68

Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol Rev (2009) 3.56

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev (1994) 3.44

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal (2012) 3.40

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proc Natl Acad Sci U S A (2013) 3.33

Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci (2010) 3.32

TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal (2010) 3.23

Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15

A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol Cell Biol (1990) 2.90

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy (2012) 2.87

Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84

Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell (2011) 2.71

The cell biology of phagocytosis. Annu Rev Pathol (2011) 2.71

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol (2013) 2.62

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet (2011) 2.60

Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell (1998) 2.48

The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J Cell Biol (2000) 2.46

Genetic disorders of programmed cell death in the immune system. Annu Rev Immunol (2006) 2.31

Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene (2003) 2.19

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathog (2008) 2.16

PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci Transl Med (2012) 2.07

The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91

Protein kinase D signaling: multiple biological functions in health and disease. Physiology (Bethesda) (2011) 1.89

Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB. Nat Cell Biol (2015) 1.88

Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils. J Cell Biol (1990) 1.85

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol (2012) 1.83

Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity (2014) 1.81

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing. Proc Natl Acad Sci U S A (2001) 1.72

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A (2002) 1.70

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proc Natl Acad Sci U S A (2015) 1.68

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis (2012) 1.60

Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo. Mol Cell Biol (1998) 1.59

The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal (2014) 1.58

Autophagy and its role in MHC-mediated antigen presentation. J Immunol (2009) 1.54

Aneuploidy-induced cellular stresses limit autophagic degradation. Genes Dev (2015) 1.54

The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development (1998) 1.52

Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo. J Exp Med (2005) 1.50

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease. EMBO Mol Med (2013) 1.44

ZKSCAN3 is a master transcriptional repressor of autophagy. Mol Cell (2013) 1.40

Isolation and characterization of early endosomes, late endosomes and terminal lysosomes: their role in protein degradation. J Cell Sci (1996) 1.35

Lysosomal physiology. Annu Rev Physiol (2015) 1.34

Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor. J Virol (2007) 1.33

CBP/p300 as a co-factor for the Microphthalmia transcription factor. Oncogene (1997) 1.31

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med (2014) 1.17

TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. Mol Cell Biol (1993) 1.16

A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev (2013) 1.15

Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis. Cell Mol Life Sci (2014) 1.14

Protein kinase C and toll-like receptor signaling. Enzyme Res (2011) 1.14

Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2015) 1.10

The endosome-lysosome pathway and information generation in the immune system. Biochim Biophys Acta (2011) 1.08

Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57Bl/6J mice. J Cell Physiol (1987) 1.05

Intracellular trafficking and replication of Burkholderia cenocepacia in human cystic fibrosis airway epithelial cells. Cell Microbiol (2006) 1.05

Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics (1999) 1.03

Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity. Nat Immunol (2006) 1.01

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A (2015) 1.00

Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14. J Leukoc Biol (2006) 1.00

Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators. J Innate Immun (2013) 1.00

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol (2015) 0.99

Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae. Arterioscler Thromb Vasc Biol (2014) 0.98

The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development. Genetics (2004) 0.98

Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells. J Biol Chem (2015) 0.97

TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. J Immunol (1999) 0.95

Insights from the worm: the C. elegans model for innate immunity. Semin Immunol (2014) 0.94

Protein kinase C controls lysosome biogenesis independently of mTORC1. Nat Cell Biol (2016) 0.93

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration. PLoS Pathog (2015) 0.93

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. J Neurosci (2015) 0.93

Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. J Immunol (2005) 0.92

AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Nature (2016) 0.92

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways. Nat Immunol (2015) 0.92

Sucrose-induced vacuolation results in increased expression of cholesterol biosynthesis and lysosomal genes. Exp Cell Res (2004) 0.91

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev (2012) 0.91

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun (2016) 0.89

Intracellular sphingosine releases calcium from lysosomes. Elife (2015) 0.88

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev (2016) 0.88