Published in Expert Rev Ophthalmol on November 23, 2016
The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol (2006) 25.47
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci (2001) 11.40
Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol (2003) 8.76
The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol (2002) 8.35
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol (1991) 7.61
Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci (2003) 7.44
Regulation of cell survival by secreted proneurotrophins. Science (2001) 6.32
Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol (2000) 6.31
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell (2007) 6.13
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science (2004) 4.74
The yin and yang of neurotrophin action. Nat Rev Neurosci (2005) 4.45
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol (2001) 4.34
Glaucoma. Lancet (2011) 4.29
Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp Zool (1951) 4.29
Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry (2008) 4.06
Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature (1997) 4.01
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell (2013) 3.91
Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci (1995) 3.78
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci (2005) 3.76
Mitochondrial dysfunction as a cause of optic neuropathies. Prog Retin Eye Res (2004) 3.75
Purification of a new neurotrophic factor from mammalian brain. EMBO J (1982) 3.68
Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature (1994) 3.64
IN VITRO AND IN VIVO EFFECTS OF A NERVE GROWTH-STIMULATING AGENT ISOLATED FROM SNAKE VENOM. Proc Natl Acad Sci U S A (1956) 3.64
Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest Ophthalmol Vis Sci (1998) 3.61
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron (1995) 3.51
Neuronal death in glaucoma. Prog Retin Eye Res (1999) 3.46
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol (2007) 3.45
Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol (2001) 3.40
Regressive events in neurogenesis. Science (1984) 3.24
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell (1990) 3.21
Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol (1989) 3.10
Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol (2014) 3.04
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell (1991) 2.97
Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J Neurosci (2008) 2.87
Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J (1990) 2.77
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci (2006) 2.68
Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology (2009) 2.60
Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci (2000) 2.56
Role of microglia in neurotrauma. Neurotherapeutics (2010) 2.53
The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci (2002) 2.53
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell (1993) 2.52
Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci (1994) 2.51
trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol (1991) 2.48
p75 and Trk: a two-receptor system. Trends Neurosci (1995) 2.39
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci (2008) 2.38
Neuronal release of proBDNF. Nat Neurosci (2009) 2.36
Retinal ganglion cells that project to the dorsal lateral geniculate nucleus in the macaque monkey. Neuroscience (1984) 2.30
Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet (1999) 2.30
Glaucoma is second leading cause of blindness globally. Bull World Health Organ (2004) 2.30
The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res (2011) 2.26
Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey. Invest Ophthalmol Vis Sci (1977) 2.24
Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci (2000) 2.18
Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron (1998) 2.18
Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci (2000) 2.14
Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest Ophthalmol Vis Sci (2000) 2.13
The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci (2010) 2.11
Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo. Nature (1995) 2.08
Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc Natl Acad Sci U S A (1994) 2.04
Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron (1991) 2.03
Binding of brain-derived neurotrophic factor to the nerve growth factor receptor. Neuron (1990) 2.02
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron (1993) 2.01
Axonal Transport in the Rat Optic Nerve Following Short-Term Reduction in Cerebrospinal Fluid Pressure or Elevation in Intraocular Pressure. Invest Ophthalmol Vis Sci (2015) 2.00
Neuroprotection in glaucoma - Is there a future role? Exp Eye Res (2010) 1.97
Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J Neurosci (1996) 1.97
Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proc Natl Acad Sci U S A (2010) 1.96
Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 1.96
Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci U S A (1990) 1.94
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J Neurosci (1995) 1.85
Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model. Invest Ophthalmol Vis Sci (2003) 1.83
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J (1999) 1.70
Lamina-specific connectivity in the brain: regulation by N-cadherin, neurotrophins, and glycoconjugates. Science (1997) 1.69
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells. J Neurosci (1986) 1.64
Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells. Proc Natl Acad Sci U S A (1998) 1.60
Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res (1993) 1.58
Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. J Neurosci (1999) 1.57
Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture. Invest Ophthalmol Vis Sci (2000) 1.56
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia (2009) 1.55
TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci (2002) 1.51
Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat. J Comp Neurol (1983) 1.51
An evidence-based assessment of risk factors for the progression of ocular hypertension and glaucoma. Am J Ophthalmol (2004) 1.50
The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron (1992) 1.47
Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Invest Ophthalmol Vis Sci (2008) 1.40
Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons. J Cell Biol (2000) 1.37
Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor. EMBO J (1992) 1.36
Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J Neurosci (1993) 1.35
Understanding proneurotrophin actions: Recent advances and challenges. Dev Neurobiol (2010) 1.35
Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. EMBO J (1991) 1.35
Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study. Invest Ophthalmol Vis Sci (1996) 1.34
Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J Neurosci (1999) 1.34
Reduced size of retinal ganglion cell axons and hypomyelination in mice lacking brain-derived neurotrophic factor. Mol Cell Neurosci (1997) 1.33
Radioautographic and cytochemical ultrastructural studies of axoplasmic transport in the monkey optic nerve head. Invest Ophthalmol Vis Sci (1978) 1.33
Depth segregation of retinal ganglion cells projecting to mouse superior colliculus. J Comp Neurol (1985) 1.30
Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons. Proc Natl Acad Sci U S A (1998) 1.29
Molecular determinants of retinal ganglion cell development, survival, and regeneration. Prog Retin Eye Res (2003) 1.29
Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development. Development (1995) 1.27
Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2. J Neurosci (1997) 1.24
Local and target-derived brain-derived neurotrophic factor exert opposing effects on the dendritic arborization of retinal ganglion cells in vivo. J Neurosci (2002) 1.24
Retinal ganglion cells that project to the superior colliculus and pretectum in the macaque monkey. Neuroscience (1984) 1.24
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival. Mol Brain (2009) 1.22