Published in Cell Death Dis on August 03, 2017
Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature (1997) 13.77
Extension of murine life span by overexpression of catalase targeted to mitochondria. Science (2005) 10.11
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature (1989) 8.48
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature (1992) 8.15
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature (1989) 7.02
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature (1991) 6.30
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature (1989) 5.86
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature (1992) 5.75
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature (1989) 5.53
Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science (1989) 4.70
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature (1993) 4.26
Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem (2005) 2.94
Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun (2001) 2.63
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochim Biophys Acta (2011) 2.39
Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A (2002) 2.38
Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A (1995) 2.24
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A (2008) 1.92
Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci U S A (2007) 1.83
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nat Cell Biol (2011) 1.70
Klotho reduces apoptosis in experimental ischaemic acute renal failure. Nephrol Dial Transplant (2005) 1.55
Kidney and pancreas transplantation in the United States, 1996-2005. Am J Transplant (2007) 1.55
Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant (2010) 1.29
Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria. Kidney Int (2010) 1.19
Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech Ageing Dev (2005) 1.19
Anti-oxidative effect of Klotho on endothelial cells through cAMP activation. Endocrine (2007) 1.12
Klotho-induced insulin resistance: a blessing in disguise? Nat Med (2006) 1.06
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem (2014) 1.00
Established and newly proposed mechanisms of chronic cyclosporine nephropathy. Korean J Intern Med (2009) 0.97
Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity. Redox Biol (2014) 0.95
Identification of novel small molecules that elevate Klotho expression. Biochem J (2012) 0.95
Statin upregulates the expression of klotho, an anti-aging gene, in experimental cyclosporine nephropathy. Nephron Exp Nephrol (2012) 0.90
Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem (2012) 0.89
Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury. Lab Invest (2015) 0.88
The renin-angiotensin system and aging in the kidney. Korean J Intern Med (2014) 0.83
Influence of N-acetylcysteine on Klotho expression and its signaling pathway in experimental model of chronic cyclosporine nephropathy in mice. Transplantation (2013) 0.80
Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway. Am J Nephrol (2016) 0.77