Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94

Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev (2004) 5.89

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci (2006) 2.58

TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest (2008) 2.55

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A (2009) 2.16

AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08

Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol (2009) 1.96

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J (2008) 1.93

Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71

Paw withdrawal threshold in the von Frey hair test is influenced by the surface on which the rat stands. J Neurosci Methods (1999) 1.50

Is topical zinc effective in the treatment of melasma? A double-blind randomized comparative study. Dermatol Surg (2013) 1.41

TRPA1: A gatekeeper for inflammation. Annu Rev Physiol (2012) 1.36

Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J (2011) 1.33

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J (2013) 1.22

Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. J Clin Aesthet Dermatol (2010) 1.13

TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain (2013) 1.09

Quinone chemistry and melanogenesis. Methods Enzymol (2004) 1.08

Common pigmentation disorders. Am Fam Physician (2009) 1.07

Skin lightening preparations and the hydroquinone controversy. Dermatol Ther (2007) 1.07

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. Br J Dermatol (2008) 1.05

Zinc as an ambivalent but potent modulator of murine hair growth in vivo- preliminary observations. Exp Dermatol (2005) 0.96

A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr Biol (2014) 0.93

Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice. Am J Respir Crit Care Med (2012) 0.93

Hydroquinone and its analogues in dermatology - a risk-benefit viewpoint. J Cosmet Dermatol (2006) 0.86

Hydroquinone therapy for post-inflammatory hyperpigmentation secondary to acne: not just prescribable by dermatologists. Acta Derm Venereol (2012) 0.84

Oral zinc sulphate causes murine hair hypopigmentation and is a potent inhibitor of eumelanogenesis in vivo. Br J Dermatol (2006) 0.82

Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells. Int J Biochem Cell Biol (2012) 0.81

Involvement of TRPA1 activation in acute pain induced by cadmium in mice. Mol Pain (2013) 0.80

Hydroquinone for skin lightening: safety profile, duration of use and when should we stop? J Dermatolog Treat (2010) 0.79

Topical corticosteroid-induced skin atrophy: a comprehensive review. Drug Saf (2015) 0.78

Selective cytotoxicity of hydroquinone for melanocyte-derived cells is mediated by tyrosinase activity but independent of melanin content. Pigment Cell Res (1988) 0.78

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Sci Rep (2016) 0.78

Depigmentation with tert-butyl hydroquinone using black guinea pigs. Food Chem Toxicol (1999) 0.78

Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. PLoS One (2016) 0.77

Topical corticosteroids in dermatology. Indian J Dermatol Venereol Leprol (2016) 0.77

Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. Sci Rep (2016) 0.77

Intradermal concentration of hydroquinone after application of hydroquinone ointments is higher than its cytotoxic concentration. Biol Pharm Bull (2003) 0.77

Calcitonin gene-related peptide cooperates with substance P to inhibit melanogenesis and induces apoptosis of B16F10 cells. Cytokine (2015) 0.77

Use of skin-lightening products among selected urban communities in Accra, Ghana. Int J Dermatol (2017) 0.76

Melasma and Post Inflammatory Hyperpigmentation: Management Update and Expert Opinion. Skin Therapy Lett (2016) 0.76

A hydroquinone formulation with increased stability and decreased potential for irritation. J Cosmet Dermatol (2007) 0.76

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy. Proc Natl Acad Sci U S A (2016) 0.75

Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. Br J Pharmacol (2017) 0.75