Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies.

SV40-transformed simian cells support the replication of early SV40 mutants. Cell (1981) 34.67

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95

Virus entry: open sesame. Cell (2006) 6.33

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol (2006) 5.58

Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae. Science (2002) 5.41

Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci U S A (1997) 3.84

New host cell system for regulated simian virus 40 DNA replication. Mol Cell Biol (1985) 2.82

Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. Cell (2007) 2.57

Caveolar endocytosis of simian virus 40 is followed by brefeldin A-sensitive transport to the endoplasmic reticulum, where the virus disassembles. J Virol (2002) 2.33

High frequency of homologous recombination in mammalian cells between endogenous and introduced SV40 genomes. Cell (1985) 2.14

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs. Blood (2006) 2.03

Influenza virus naked RNA can be expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from simian virus 40 recombinant viruses. J Gen Virol (1993) 1.74

Simian virus 40 infection of humans. J Virol (2003) 1.71

Role of endosomes in simian virus 40 entry and infection. J Virol (2011) 1.46

Interaction of the Vp3 nuclear localization signal with the importin alpha 2/beta heterodimer directs nuclear entry of infecting simian virus 40. J Virol (2002) 1.40

Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines. Expert Rev Vaccines (2009) 1.38

A lipid receptor sorts polyomavirus from the endolysosome to the endoplasmic reticulum to cause infection. PLoS Pathog (2009) 1.25

Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection. J Virol (2005) 1.24

Insulin-like growth factor I gene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats. Hepatology (2010) 1.12

Simian virus 40 infection in humans and association with human diseases: results and hypotheses. Virology (2004) 1.10

Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. Hum Gene Ther (2012) 1.08

Tolerance induction by viral in vivo gene transfer. Clin Med Res (2005) 1.07

A replication-deficient rSV40 mediates liver-directed gene transfer and a long-term amelioration of jaundice in gunn rats. Gastroenterology (2000) 0.96

Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them. Rev Med Virol (2013) 0.95

Generation of recombinant SV40 vectors for gene transfer. Methods Mol Biol (2001) 0.94

Liver transduction with a simian virus 40 vector encoding insulin-like growth factor I reduces hepatic damage and the development of liver cirrhosis. Gene Ther (2006) 0.93

Development of Gene Transfer for Induction of Antigen-specific Tolerance. Mol Ther Methods Clin Dev (2014) 0.93

Efficient CNS gene delivery by intravenous injection. Nat Methods (2010) 0.91

ERAD and how viruses exploit it. Front Microbiol (2014) 0.91

In vitro-packaged SV40 pseudovirions as highly efficient vectors for gene transfer. Hum Gene Ther (2002) 0.90

Role of SV40 ST antigen in the persistent infection of mesothelial cells. Virology (2007) 0.90

CV-1 monkey kidney cell line -- a highly susceptible substrate for diagnosis and study of arboviruses. Acta Virol (1978) 0.84

Helpers for efficient encapsidation of SV40 pseudovirions. Gene (1989) 0.83

Factors influencing the production of recombinant SV40 vectors. Mol Ther (2004) 0.82

Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe. Gene Ther (2011) 0.82

Dynamics of antigen presentation to transgene product-specific CD4(+) T cells and of Treg induction upon hepatic AAV gene transfer. Mol Ther Methods Clin Dev (2016) 0.82

Strategies to circumvent humoral immunity to adeno-associated viral vectors. Expert Opin Biol Ther (2015) 0.81

The Skeletal Muscle Environment and Its Role in Immunity and Tolerance to AAV Vector-Mediated Gene Transfer. Curr Gene Ther (2015) 0.80

A new packaging cell line for SV40 vectors that eliminates the generation of T-antigen-positive, replication-competent recombinants. Virology (2002) 0.79

Insulin-Like Growth Factor I (IGF-I) Expressed from an AAV1 Vector Leads to a Complete Reversion of Liver Cirrhosis in Rats. PLoS One (2016) 0.79

Early Insights from Commercialization of Gene Therapies in Europe. Genes (Basel) (2017) 0.78

Massively parallel sequencing for the detection of adventitious viruses. PDA J Pharm Sci Technol (2012) 0.78

Autoimmune Aspects of Neurodegenerative and Psychiatric Diseases: A Template for Innovative Therapy. Front Psychiatry (2017) 0.78