PubRank

D Duboule

Author PubWeight™ 98.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications. Proc Natl Acad Sci U S A 1997 2.72
2 Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 1992 2.42
3 Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol 2001 2.41
4 Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature 1989 2.40
5 Hox gene expression in teleost fins and the origin of vertebrate digits. Nature 1995 2.35
6 The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene. EMBO J 1990 2.12
7 Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 1993 2.09
8 Of fingers, toes and penises. Nature 1997 2.00
9 Engineering chromosomes in mice through targeted meiotic recombination (TAMERE). Nat Genet 1998 1.97
10 Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body. EMBO J 1991 1.88
11 Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron 1992 1.85
12 Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2. Proc Natl Acad Sci U S A 1988 1.79
13 Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing. Nat Genet 2000 1.78
14 A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus. EMBO J 1986 1.77
15 Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 1996 1.71
16 HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. EMBO J 1991 1.70
17 HOX-4 genes and the morphogenesis of mammalian genitalia. Genes Dev 1991 1.69
18 Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations. Genes Dev 2001 1.68
19 Breaking colinearity in the mouse HoxD complex. Cell 1999 1.63
20 A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature 1991 1.63
21 Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex. EMBO J 1987 1.61
22 Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature 1996 1.57
23 Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Nature 1991 1.54
24 Viral enhancer activity in teratocarcinoma cells. Cold Spring Harb Symp Quant Biol 1985 1.49
25 Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads. EMBO J 1989 1.44
26 Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage. Nature 1987 1.41
27 Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation. Development 1989 1.32
28 Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development 1996 1.31
29 Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell 2001 1.29
30 In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes Dev 1996 1.29
31 Hox genes in digit development and evolution. Cell Tissue Res 1999 1.29
32 Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13. Dev Dyn 1997 1.28
33 The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development. Development 1989 1.21
34 Interspecies exchange of a Hoxd enhancer in vivo induces premature transcription and anterior shift of the sacrum. Dev Biol 1997 1.20
35 Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development. Differentiation 1992 1.16
36 Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex. Genes Dev 2000 1.16
37 Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J 1997 1.15
38 Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. EMBO J 1993 1.13
39 Control of colinearity in AbdB genes of the mouse HoxD complex. Mol Cell 1998 1.12
40 Hox gene expression in limbs: colinearity by opposite regulatory controls. Dev Biol 1999 1.08
41 Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex. Mech Dev 1996 1.06
42 Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Development 1997 1.05
43 Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene. Development 1990 1.05
44 The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. Mech Dev 1991 1.05
45 Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes. EMBO J 1994 1.01
46 A molecular genetic linkage map of mouse chromosome 2. Genomics 1990 1.00
47 Functional equivalence and rescue among group 11 Hox gene products in vertebral patterning. Dev Biol 1996 0.99
48 Hox genes and the making of sphincters. Nature 1999 0.99
49 Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc Natl Acad Sci U S A 1993 0.98
50 The mouse Hoxd13(spdh) mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes. Dev Biol 2001 0.98
51 A molecular approach to the evolution of vertebrate paired appendages. Trends Ecol Evol 1996 0.97
52 Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex. Development 1998 0.96
53 Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J 1996 0.96
54 Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development. Development 1994 0.95
55 Dorso-ventral limb polarity and origin of the ridge: on the fringe of independence? Bioessays 1997 0.95
56 DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues. Mol Cell Biol 1987 0.94
57 Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4. EMBO J 1992 0.93
58 Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex. Dev Suppl 1994 0.91
59 Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach? Dev Dyn 1998 0.91
60 Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and implications for the functional evolution of posterior Hox genes. Mech Dev 1996 0.90
61 Homeobox genes and pattern formation in the vertebrate limb. Dev Biol 1992 0.89
62 Transgenic analysis of a potential Hoxd-11 limb regulatory element present in tetrapods and fish. Dev Biol 1996 0.89
63 Differential expression of two different homeobox gene families during mouse tegument morphogenesis. Int J Dev Biol 1994 0.89
64 An update of mouse and human HOX gene nomenclature. Genomics 1990 0.88
65 Hox genes and the morphogenesis of the vertebrate limb. Prog Clin Biol Res 1993 0.85
66 The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics 1990 0.84
67 Correlation of expression of Wnt-1 in developing limbs with abnormalities in growth and skeletal patterning. Nature 1993 0.83
68 The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity. Development 1992 0.83
69 Developmental genetics. A Hox by any other name. Nature 2000 0.83
70 The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2. Genomics 1990 0.83
71 Classification of limb defects. Am J Med Genet 1998 0.82
72 Antagonists go out on a limb. Cell 1999 0.80
73 The murine even-skipped-like gene Evx-2 is closely linked to the Hox-4 complex, but is transcribed in the opposite direction. Mamm Genome 1992 0.80
74 Tissue preference and differentiation of malignant rat x mouse hybrid cells in chimaeric mouse fetuses. EMBO J 1982 0.79
75 Development. The art of making a joint. Science 2001 0.78
76 Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth. EMBO J 1992 0.77
77 [Hox genes and genetic control of limb development]. Arch Pediatr 1997 0.76
78 The evolution of genomics. Science 1997 0.75
79 A fine analysis of glucose-phosphate-isomerase patterns in single preimplantation mouse embryos. Differentiation 1985 0.75
80 Genetic control of murine limb morphogenesis: relationships with human syndromes and evolutionary relevance. Mol Cell Endocrinol 1998 0.75
81 [Genetic control of limb development]. Ann Genet 1996 0.75
82 Hox-4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms. Development 1992 0.75
83 Protein synthesis in hybrid cells derived from fetal rat x mouse chimeric organs. Differentiation 1982 0.75
84 18 Muscle and tendon pattern is altered independently of skeletal pattern in HoxD mutant limbs. J Anat 2002 0.75
85 [Control of limb morphogenesis by the Hox genes]. C R Seances Soc Biol Fil 1997 0.75
86 Cooperation of regulatory elements involved in the activation of the Hoxd-11 gene. C R Acad Sci III 1993 0.75