The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28804567)

Published in Am J Transl Res on July 15, 2017

Authors

Sanjaya Kuruppu1, Niwanthi W Rajapakse2,3, Helena C Parkington3, A Ian Smith1

Author Affiliations

1: Biomedicine Discovery Institute, Department of Biochemistry & Molecular Biology, 23 Innovation Walk, Monash UniversityVic 3800, Australia.
2: Baker IDI Heart and Diabetes Institute75 Commercial Rd, Melbourne, Vic 3004, Australia.
3: Biomedicine Discovery Institute, Department of Physiology, Monash UniversityClayton, Vic 3800, Australia.

Articles cited by this

Alzheimer's disease: the amyloid cascade hypothesis. Science (1992) 13.80

The molecular pathology of Alzheimer's disease. Neuron (1991) 8.21

Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science (2010) 8.04

2014 Alzheimer's disease facts and figures. Alzheimers Dement (2014) 3.45

Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res (2003) 1.43

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J Neurochem (2011) 1.32

Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Res (1998) 1.25

Physiological roles for amyloid beta peptides. J Physiol (2006) 1.16

The role of astrocytes in amyloid β-protein toxicity and clearance. Exp Neurol (2012) 1.04

Does Abeta 42 have a function related to blood homeostasis? Neurochem Res (2006) 0.89

NSAIDs: How they Work and their Prospects as Therapeutics in Alzheimer's Disease. Front Aging Neurosci (2010) 0.86

Metabolic Dysfunction of Astrocyte: An Initiating Factor in Beta-amyloid Pathology? Aging Neurodegener (2013) 0.86

Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front Aging Neurosci (2014) 0.85

The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate. Am J Transl Res (2016) 0.82

Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization. Mol Brain (2015) 0.79

Mechanisms of Aβ Clearance and Degradation by Glial Cells. Front Aging Neurosci (2016) 0.79