PubRank

M L Birnstiel

Author PubWeight™ 285.18‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A simple method for DNA restriction site mapping. Nucleic Acids Res 1976 22.24
2 Transcription termination and 3' processing: the end is in site! Cell 1985 17.46
3 Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo. Proc Natl Acad Sci U S A 1980 16.88
4 Kinetic complexity of RNA molecules. J Mol Biol 1972 9.07
5 Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are essential for promotion of H2A histone gene transcription in vivo. Proc Natl Acad Sci U S A 1980 7.31
6 The organization and expression of histone gene families. Cell 1981 6.66
7 Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements. Nature 1981 6.20
8 Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing. Cell 1978 5.18
9 3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors. Proc Natl Acad Sci U S A 1984 4.99
10 Sea urchin histone mRNA termini are located in gene regions downstream from putative regulatory sequences. Nature 1980 4.51
11 A split promoter for a eucaryotic tRNA gene. Cell 1981 4.18
12 Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants. Nucleic Acids Res 1980 3.80
13 Expression of sea urchin histone genes in the oocyte of Xenopus laevis. J Mol Biol 1979 3.50
14 Ribosomal cistrons and the nucleolar organizer. Biochim Biophys Acta 1966 3.47
15 Generation of histone mRNA 3' ends by endonucleolytic cleavage of the pre-mRNA in a snRNP-dependent in vitro reaction. EMBO J 1986 3.45
16 The cDNA sequences of the sea urchin U7 small nuclear RNA suggest specific contacts between histone mRNA precursor and U7 RNA during RNA processing. EMBO J 1984 3.36
17 Biochemical complementation with RNA in the Xenopus oocyte: a small RNA is required for the generation of 3' histone mRNA termini. Cell 1983 3.36
18 Generation of authentic 3' termini of an H2A mRNA in vivo is dependent on a short inverted DNA repeat and on spacer sequences. Cell 1982 3.35
19 A tRNA gene of Xenopus laevis contains at least two sites promoting transcription. Nucleic Acids Res 1979 3.30
20 The terminal RNA stem-loop structure and 80 bp of spacer DNA are required for the formation of 3' termini of sea urchin H2A mRNA. Cell 1983 3.19
21 Mature mRNA 3' end formation stimulates RNA export from the nucleus. EMBO J 1991 3.09
22 Delimitation of a promoter for RNA polymerase III by means of a functional test. Proc Natl Acad Sci U S A 1979 2.97
23 Delimitation of far upstream sequences required for maximal in vitro transcription of an H2A histone gene. Proc Natl Acad Sci U S A 1982 2.90
24 Transcription of xenopus tDNAmet1 and sea urchin histone DNA injected into the Xenopus oocyte nucleus. Cold Spring Harb Symp Quant Biol 1978 2.84
25 RNA-DNA hybrids at the cytological level. Nature 1969 2.81
26 Structure and expression in L-cells of a cloned H4 histone gene of the mouse. J Mol Biol 1981 2.76
27 Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction. EMBO J 1988 2.74
28 Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA. Nature 1986 2.74
29 Transcription of cloned tRNA gene fragments and subfragments injected into the oocyte nucleus of Xenopus laevis. Proc Natl Acad Sci U S A 1978 2.70
30 Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc Natl Acad Sci U S A 1990 2.64
31 Mapping of the Xenopus laevis 5.8S rDNA by restriction and DNA sequencing. Nucleic Acids Res 1978 2.54
32 More ribosomal spacer sequences from Xenopus laevis. Nucleic Acids Res 1980 2.50
33 The ribosomal RNA cistrons. Prog Nucleic Acid Res Mol Biol 1971 2.47
34 Localization of the ribosomal DNA complements in the nucleolar organizer region of Xenopus laevis. Natl Cancer Inst Monogr 1966 2.45
35 The conserved CAAGAAAGA spacer sequence is an essential element for the formation of 3' termini of the sea urchin H3 histone mRNA by RNA processing. EMBO J 1985 2.34
36 Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3' processing of H3 pre-mRNA in the oocyte. EMBO J 1986 2.29
37 Heat-labile regulatory factor is required for 3' processing of histone precursor mRNAs. Proc Natl Acad Sci U S A 1987 2.28
38 Ribozyme mediated destruction of RNA in vivo. EMBO J 1989 2.22
39 The putative promoter of a Xenopus laevis ribosomal gene is reduplicated. Nucleic Acids Res 1979 2.07
40 Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor. Proc Natl Acad Sci U S A 1989 2.02
41 Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptor. Nucleic Acids Res 1976 1.99
42 High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc Natl Acad Sci U S A 1992 1.90
43 Reiteration and clustering of DNA sequences complementary to histone messenger RNA. Nat New Biol 1971 1.90
44 Localization of amplified ribosomal DNA in the oocyte of Xenopus laevis. Biochim Biophys Acta 1968 1.88
45 Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proc Natl Acad Sci U S A 1992 1.87
46 Transcriptional fidelity of histone genes injected into Xenopus oocyte nuclei. Nature 1980 1.81
47 Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc Natl Acad Sci U S A 1991 1.80
48 Processing and nucleo-cytoplasmic transport of histone gene transcripts. Nucleic Acids Res 1984 1.80
49 Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc Natl Acad Sci U S A 1990 1.79
50 Bioassay for components regulating eukaryotic gene expression: a chromosomal factor involved in the generation of histone mRNA 3' termini. Proc Natl Acad Sci U S A 1982 1.77
51 Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2'-O-methyl oligoribonucleotides. Proc Natl Acad Sci U S A 1991 1.76
52 SYNTHESIS OF TRANSFER RNA BY ISOLATED NUCLEI. Proc Natl Acad Sci U S A 1963 1.73
53 Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc Natl Acad Sci U S A 1992 1.72
54 Transcription of a cloned Xenopus laevis H4 histone gene in the homologous frog oocyte system depends on an evolutionary conserved sequence motif in the -50 region. Nucleic Acids Res 1983 1.70
55 Genes coding for polysomal 9S RNA of sea urchins: conservation and divergence. Nature 1972 1.65
56 Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. Proc Natl Acad Sci U S A 1990 1.64
57 Point mutation in the TATA box curtails expression of sea urchin H2A histone gene in vivo. Nature 1981 1.51
58 Location of the genes for 5S ribosomal RNA in Xenopus laevis. Chromosoma 1973 1.50
59 Reiterated transfer RNA genes of Xenopus laevis. J Mol Biol 1973 1.48
60 Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro. Mol Cell Biol 1989 1.48
61 An unusual evolutionary behaviour of a sea urchin histone gene cluster. EMBO J 1982 1.48
62 High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. Hum Gene Ther 1992 1.45
63 Properties of the ribosomal RNA precursor in Xenopus laevis; comparison to the precursor in mammals and in plants. J Mol Biol 1969 1.44
64 2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. Nucleic Acids Res 1991 1.39
65 Localization of sequences coding for histone messenger RNA in the chromosomes of Drosophila melanogaster. Chromosoma 1977 1.33
66 The replication of purified DNA introduced into living egg cytoplasm. Biochim Biophys Acta 1969 1.27
67 NK-kappa B subunit-specific regulation of the I kappa B alpha promoter. J Biol Chem 1994 1.24
68 Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif. Nucleic Acids Res 1989 1.22
69 Histone genes from Xenopus laevis: molecular cloning and initial characterization. Gene 1980 1.21
70 DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety. Bioconjug Chem 1992 1.21
71 Major changes in the 5' and 3' chromatin structure of sea urchin histone genes accompany their activation and inactivation in development. Cell 1983 1.21
72 Nucleosome arrangement on tRNA genes of Xenopus laevis. Cell 1981 1.20
73 Functional analysis of the sea urchin U7 small nuclear RNA. Mol Cell Biol 1988 1.20
74 Cell cycle-dependent regulation of histone precursor mRNA processing by modulation of U7 snRNA accessibility. Nature 1990 1.20
75 Detection of labelled RNA species by contact hybridization. Nucleic Acids Res 1979 1.18
76 Developmental regulation of micro-injected histone genes in sea urchin embryos. Dev Biol 1988 1.17
77 Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. Virology 1994 1.16
78 Integrity of the DNA template, a prerequisite for the faithful transcription of Xenopus rDNA in vitro. Eur J Biochem 1972 1.15
79 Analysis of a sea urchin gene cluster coding for the small nuclear U7 RNA, a rare RNA species implicated in the 3' editing of histone precursor mRNAs. Proc Natl Acad Sci U S A 1986 1.15
80 Reiteration frequency of the histone genes in the genome of the amphibian, Xenopus laevis. Eur J Biochem 1976 1.09
81 Stimulation of sea urchin H2B histone gene transcription by a chromatin-associated protein fraction depends on gene sequences downstream of the transcription start site. Mol Cell Biol 1985 1.07
82 Biochemical and ultrastructural characteristics of ribonucleoprotein particles isolated from rat-liver cell nucleoli. Biochim Biophys Acta 1969 1.07
83 DNA sequences coding for the H2B histone of Psammechinus miliaris. Nature 1977 1.06
84 5'-Labeling and poly(dA) tailing. Methods Enzymol 1980 1.04
85 Gene amplification in the oocyte nucleus of mutant and wild-type Xenopus laevis. Nature 1968 1.04
86 Analysis of a gene cluster coding for the Xenopus laevis U7 snRNA. Biochim Biophys Acta 1992 1.03
87 Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination. Proc Natl Acad Sci U S A 1995 1.02
88 Clustering of transfer RNA genes of Xenopus laevis. J Mol Biol 1973 1.02
89 Transloading of tumor antigen-derived peptides into antigen-presenting cells. Proc Natl Acad Sci U S A 1997 1.00
90 Clustered arrangement of tRNA genes of Xenopus laevis. Cold Spring Harb Symp Quant Biol 1974 1.00
91 A functional component of the sea urchin H2A gene modulator contains an extended sequence homology to a viral enhancer. Nucleic Acids Res 1983 0.99
92 Analysis of histone messenger RNA of Drosophila melanogaster by two-dimensional gel electrophoresis. J Mol Biol 1978 0.97
93 Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants. J Virol 1993 0.97
94 Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex. Hum Gene Ther 1995 0.97
95 Reiteration frequency of histone coding sequences in man. Biochem Biophys Res Commun 1974 0.96
96 Scattered arrangement of the bacterial ribosomal cistrons. Nature 1970 0.94
97 Receptor-mediated transport of DNA into eukaryotic cells. Methods Enzymol 1993 0.94
98 The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins. Mol Cell Biol 1997 0.92
99 Cancer vaccines: the interleukin 2 dosage effect. Proc Natl Acad Sci U S A 1995 0.91
100 Some bacterial tRNA genes are transcribed by eukaryotic RNA polymerase III. Nucleic Acids Res 1982 0.91
101 Evolutionary conserved multiprotein complexes interact with the 3' untranslated region of histone transcripts. Nucleic Acids Res 1992 0.90
102 Transferrinfection: a highly efficient way to express gene constructs in eukaryotic cells. Ann N Y Acad Sci 1992 0.89
103 Regulation of histone gene expression. Cold Spring Harb Symp Quant Biol 1985 0.88
104 Somatic gene therapy for cancer: the utility of transferrinfection in generating 'tumor vaccines'. Gene 1993 0.87
105 The inability of the Psammechinus miliaris H3 RNA to be processed in the Xenopus oocyte is associated with sequences distinct from those highly conserved amongst sea urchin histone RNAs. Nucleic Acids Res 1987 0.87
106 Molecular hybridization of 3H-labelled ribosomal RNA with DNA in ultrathin sections prepared for electron microscopy. Biochim Biophys Acta 1971 0.87
107 The arrangement of 18-S and 28-S ribosomal ribonucleic acids within the 40-S precursor molecule of Xenopus laevis. Eur J Biochem 1976 0.85
108 A timing study of DNA amplification in Xenopus laevis oocytes. Chromosoma 1971 0.85
109 In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery. Proc Natl Acad Sci U S A 1994 0.84
110 Cell-free tumor antigen peptide-based cancer vaccines. Proc Natl Acad Sci U S A 1997 0.83
111 Amphibian oocytes and sphere organelles: are the U snRNA genes amplified? Chromosoma 1992 0.82
112 Observations on fine structure in pea nucleoli in situ and isolated. J Ultrastruct Res 1965 0.81
113 Synthesis of transfer RNA in the nucleolus of Smittia. Natl Cancer Inst Monogr 1966 0.80
114 Analysis of nucleolar RNA synthesis in dipteran salivary glands. Arch Biol (Liege) 1965 0.80
115 Transloading of tumor cells with foreign major histocompatibility complex class I peptide ligand: a novel general strategy for the generation of potent cancer vaccines. Proc Natl Acad Sci U S A 1996 0.79
116 Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway. Am J Respir Cell Mol Biol 1992 0.78
117 Preparation of adenovirus-polylysine-DNA complexes. Curr Protoc Hum Genet 2001 0.78
118 Depletion of naive T cells of the peripheral lymph nodes abrogates systemic antitumor protection conferred by IL-2 secreting cancer vaccines. Gene Ther 1996 0.78
119 Synthesis of different species of nucleolar ribonucleic acid. Biochim Biophys Acta 1965 0.77
120 Histone H4 mRNA levels are down-regulated by 3' RNA processing during terminal differentiation of myoblasts. Biochim Biophys Acta 1992 0.77
121 Histone mRNA in Xenopus laevis ovaries: identification of the H4 messenger. Nucleic Acids Res 1977 0.77
122 Tumor vaccines: effects and fate of IL-2 transfected murine melanoma cells in vivo. Int J Immunopharmacol 1995 0.76
123 The relationship between protein synthesis and ribosomal DNA amplification in Xenopus laevis. Biochim Biophys Acta 1971 0.76
124 Generation of effective cancer vaccines genetically engineered to secrete cytokines using adenovirus-enhanced transferrinfection (AVET). Gene 1997 0.75
125 Further liaisons with sperm. Science 1989 0.75
126 Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene. Hum Gene Ther 1996 0.75
127 Aspects of the regulation of histone genes. Philos Trans R Soc Lond B Biol Sci 1978 0.75
128 Adenovirus-enhanced receptor-mediated transferrinfection for the generation of tumor vaccines. Cytokines Mol Ther 1996 0.75
129 3 processing of histone RNA precursors. Mol Biol Rep 1990 0.75
130 Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene. J Mol Med (Berl) 1997 0.75
131 Rhynchosciara angelae salivary gland DNA: kinetic complexity and transcription of repetitive sequences. Basic Life Sci 1973 0.75
132 Developmental control of histone gene expression. Prog Clin Biol Res 1982 0.75
133 Histones in the wild-type and the anucleolate mutant of Xenopus laevis. Science 1967 0.75
134 Sea urchin histone genes: the beginning and end of the message. Philos Trans R Soc Lond B Biol Sci 1984 0.75
135 Moving from Zurich to Vienna--up or down? Biol Chem 1999 0.75
136 Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. Glycobiology 1994 0.75