Fluconazole resistance in Candida species: a current perspective.

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Published in Infect Drug Resist on July 31, 2017

Authors

Elizabeth L Berkow1, Shawn R Lockhart1

Author Affiliations

1: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.

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First hospital outbreak of the globally emerging Candida auris in a European hospital. Antimicrob Resist Infect Control (2016) 0.91

Evolutionary dynamics of Candida albicans during in vitro evolution. Eukaryot Cell (2011) 0.90

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Upregulation of the ERG11 gene in Candida krusei by azoles. Daru (2010) 0.86

Erg11 mutations associated with azole resistance in clinical isolates of Candida albicans. FEMS Yeast Res (2013) 0.86

Analysis of a fungus-specific transcription factor family, the Candida albicans zinc cluster proteins, by artificial activation. Mol Microbiol (2013) 0.84

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Predicting the emergence of resistance to antifungal drugs. FEMS Microbiol Lett (2001) 0.83

Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis. J Mass Spectrom (2002) 0.83