Published in Oncotarget on May 09, 2017
Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis. Oncogenesis (2017) 0.75
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 74.55
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Glioblastoma and other malignant gliomas: a clinical review. JAMA (2013) 4.99
Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial. JAMA (2015) 4.00
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol (2004) 2.68
ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab (2009) 2.49
Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema. Nat Med (2008) 1.66
Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res (2005) 1.58
Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines. Oncogene (2007) 1.32
Surgical resection of malignant gliomas-role in optimizing patient outcome. Nat Rev Neurol (2013) 1.31
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. J Clin Invest (2015) 1.17
Genomic analysis of xCT-mediated regulatory network: Identification of novel targets against AIDS-associated lymphoma. Oncotarget (2015) 1.02
xCT modulation in gliomas: relevance to energy metabolism and tumor microenvironment normalization. Ann Anat (2010) 1.01
Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines. Cancer Res (2003) 0.99
Targeting the ATF4 pathway in cancer therapy. Expert Opin Ther Targets (2012) 0.96
Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide. Drug Discov Today (2015) 0.95
Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. Cancer Lett (2014) 0.95
Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomas. Oncogene (2010) 0.91
Current medical treatment of glioblastoma. Cancer Treat Res (2015) 0.91
Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema. Oncotarget (2016) 0.88
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell (2016) 0.88
Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight. Curr Neuropharmacol (2015) 0.87
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism. Cell Rep (2016) 0.87
The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-). Cancer Res (2016) 0.86
Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival. Oncotarget (2016) 0.82
Preconditioning with high mobility group box 1 (HMGB1) induces lipoteichoic acid (LTA) tolerance. J Immunother (2010) 0.81
Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy. Exp Ther Med (2016) 0.79
Crosstalk between ATF4 and MTA1/HDAC1 promotes osteosarcoma progression. Oncotarget (2016) 0.78
Glioblastoma: Defining Tumor Niches. Trends Cancer (2015) 0.78
Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis. Oncotarget (2016) 0.78
ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis. Oncotarget (2016) 0.77
The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress. Oncotarget (2016) 0.75
The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas. Oncotarget (2017) 0.76