Published in Eur J Clin Pharmacol on September 17, 2017
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis (1998) 16.20
Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J Appl Physiol (1985) (1986) 6.86
Intracellular distribution and activity of antibiotics. Eur J Clin Microbiol Infect Dis (1991) 2.28
Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model. Antimicrob Agents Chemother (1994) 2.28
Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock. Crit Care Med (2001) 1.50
Microdialysis. A novel tool for clinical studies of anti-infective agents. Eur J Clin Pharmacol (2001) 1.34
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia. Crit Care (2012) 1.18
Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis. Antimicrob Agents Chemother (2003) 1.03
The importance of tissue penetration in achieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus: vancomycin and linezolid. Curr Med Res Opin (2010) 1.02
The impact of perioperative atelectasis on antibiotic penetration into lung tissue: an in vivo microdialysis study. Intensive Care Med (2008) 0.86
Tissue pharmacokinetics of levofloxacin in human soft tissue infections. Br J Clin Pharmacol (2004) 0.84
Pharmacokinetics of piperacillin in critically ill patients receiving continuous venovenous haemofiltration: A randomised controlled trial of continuous infusion versus intermittent bolus administration. Int J Antimicrob Agents (2015) 0.81
Optimization of dosing regimens and dosing in special populations. Clin Microbiol Infect (2015) 0.81
Important drug classes associated with potential drug-drug interactions in critically ill patients: highlights for cardiothoracic intensivists. Ann Intensive Care (2015) 0.80
Vemurafenib resistance signature by proteome analysis offers new strategies and rational therapeutic concepts. Mol Cancer Ther (2015) 0.89
NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro. Oncotarget (2015) 0.84
A FIM study to assess safety and exposure of inhaled single doses of AP301-A specific ENaC channel activator for the treatment of acute lung injury. J Clin Pharmacol (2014) 0.83
Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line: prooxidative potential of hydroxylated resveratrol analogs. Chem Biol Interact (2014) 0.81
Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[11C]verapamil PET study. J Cereb Blood Flow Metab (2015) 0.80
Dexmedetomidine as adjunct to ilioinguinal/iliohypogastric nerve blocks for pediatric inguinal hernia repair: an exploratory randomized controlled trial. Paediatr Anaesth (2015) 0.79
AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis. Hum Mol Genet (2016) 0.78
Patients' handling of a standardized medication plan: a pilot study and method development. Patient Prefer Adherence (2016) 0.77
Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. Cancer Lett (2014) 0.77
Interplay between metabolism and transport of resveratrol. Ann N Y Acad Sci (2013) 0.77
Ramipril modulates circadian gene expression in skeletal muscle. Pharmacogenet Genomics (2011) 0.76
Cerebral and Peripheral Metabolism to Predict Successful Reperfusion After Cardiac Arrest in Rats: A Microdialysis Study. Neurocrit Care (2016) 0.76
Single- and Repeated-Dose Pharmacokinetics of Ceftaroline in Plasma and Soft Tissues of Healthy Volunteers for Two Different Dosing Regimens of Ceftaroline Fosamil. Antimicrob Agents Chemother (2016) 0.75
Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[(11) C]verapamil in elderly vs. young subjects. Br J Clin Pharmacol (2017) 0.75
Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children. Eur J Endocrinol (2020) 0.75
In search of a standard when analyzing medication adherence in patients with heart failure using claims data: a systematic review. Heart Fail Rev (2017) 0.75
Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC) Receiving Erlotinib Treatment. Basic Clin Pharmacol Toxicol (2017) 0.75
Human Bile Reduces Antimicrobial Activity of Selected Antibiotics Against Enterococcus faecalis and Escherichia coli in vitro. Antimicrob Agents Chemother (2017) 0.75
Influence of tedizolid on the cytokine response to the endotoxin challenge in healthy volunteers: a cross-over trial. J Antimicrob Chemother (2022) 0.75
Biomarkers Predicting Tissue Pharmacokinetics of Antimicrobials in Sepsis: A Review. Clin Pharmacokinet (2022) 0.75
The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells. Int J Oncol (2014) 0.75
Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model. Int J Oncol (2017) 0.75
Tissue pharmacokinetics of telavancin in healthy volunteers: a microdialysis study. J Antimicrob Chemother (2016) 0.75
Acetylic Salicylic Acid for the Treatment of Chronic Obstructive Pulmonary Disease: A Randomized, Double-Blind, Placebo-Controlled Trial. Pharmacology (2016) 0.75
Influence of OATPs on hepatic disposition of erlotinib measured with positron emission tomography. Clin Pharmacol Ther (2017) 0.75
Cefazolin and linezolid penetration into sternal cancellous bone during coronary artery bypass grafting. Eur J Cardiothorac Surg (2014) 0.75
Thrombocytopenia following high-dose chemotherapy with carboplatin, etoposide and thiotepa in patients with testicular germ cell cancer. Int J Clin Pharmacol Ther (2013) 0.75
Iontophoresis driven concentrations of topically administered diclofenac in skeletal muscle and blood of healthy subjects. Eur J Clin Pharmacol (2015) 0.75
Pharmacokinetics of the Inhaled Selective Glucocorticoid Receptor Modulator AZD5423 Following Inhalation Using Different Devices. AAPS J (2017) 0.75
Translational pharmacometric evaluation of typical antibiotic broad-spectrum combination therapies against Staphylococcus aureus exploiting in vitro information. CPT Pharmacometrics Syst Pharmacol (2017) 0.75
Evaluating patients' comprehensibility of a standardized medication plan. Eur J Clin Pharmacol (2016) 0.75