Published in MBio on September 19, 2017
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30
Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol (2010) 7.95
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol (2003) 7.06
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature (1998) 6.47
Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol (2002) 6.38
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol (2014) 6.25
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24
Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell (1998) 5.32
Role of BAX in the apoptotic response to anticancer agents. Science (2000) 5.07
Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med (2006) 5.01
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A (2006) 4.84
Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron (1995) 4.07
Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science (2009) 3.94
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem (2000) 3.85
Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. J Biol Chem (1998) 3.67
Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem (1998) 2.93
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest (2009) 2.85
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene (2007) 2.85
The structure of the nuclear pore complex. Annu Rev Biochem (2011) 2.70
Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. Apoptosis (2000) 2.63
Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol (2005) 2.57
Paralytic poliomyelitis: seasoned strategies, disappearing disease. Lancet (1994) 2.54
Effects of poliovirus infection on nucleo-cytoplasmic trafficking and nuclear pore complex composition. EMBO J (2001) 2.47
Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor. Proc Natl Acad Sci U S A (2007) 2.38
Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem (2002) 2.37
Viral apoptosis is induced by IRF-3-mediated activation of Bax. EMBO J (2010) 2.36
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity (2011) 2.29
Viral control of mitochondrial apoptosis. PLoS Pathog (2008) 2.21
Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J Biol Chem (2004) 2.16
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. J Virol (2006) 2.15
The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J (2001) 2.14
Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J Exp Med (1998) 2.11
Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells. Proc Natl Acad Sci U S A (1996) 1.99
Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J Virol (2002) 1.92
Caspases: their intracellular localization and translocation during apoptosis. Cell Death Differ (1999) 1.92
Apoptosis-inducing and apoptosis-preventing functions of poliovirus. J Virol (1995) 1.88
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog (2010) 1.82
Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. J Biol Chem (2007) 1.81
Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol (2009) 1.77
A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins. Nat Immunol (2001) 1.74
Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor. Mol Cell (2011) 1.73
The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. PLoS Pathog (2011) 1.70
Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J (2002) 1.62
Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol (2011) 1.61
Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. J Biol Chem (2001) 1.60
Nucleocytoplasmic traffic disorder induced by cardioviruses. J Virol (2006) 1.59
The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins. J Virol (2004) 1.58
Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. Mol Cell Biol (1999) 1.54
RIG-I is cleaved during picornavirus infection. Virology (2009) 1.51
Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J Biol Chem (2004) 1.50
Mechanism of PKR Activation by dsRNA. J Mol Biol (2008) 1.42
Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling. J Biol Chem (2008) 1.36
Apoptosis precedes necrosis of dystrophin-deficient muscle. J Cell Sci (1995) 1.35
Stable formation of compositionally unique stress granules in virus-infected cells. J Virol (2010) 1.34
The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. J Biol Chem (2004) 1.23
Architecture of the symmetric core of the nuclear pore. Science (2016) 1.22
The cis-acting replication elements define human enterovirus and rhinovirus species. RNA (2008) 1.21
The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. Virology (2009) 1.19
Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD. PLoS Pathog (2011) 1.18
Enhanced intracellular calcium concentration during poliovirus infection. J Virol (1995) 1.18
Induction of apoptosis is driven by nuclear retention of protein kinase C delta. J Biol Chem (2007) 1.18
Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking. J Virol (2008) 1.15
The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors. Oncogene (2000) 1.15
Cleavage of IPS-1 in cells infected with human rhinovirus. J Virol (2009) 1.14
Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease. J Biol Chem (2010) 1.13
Sam68 exerts separable effects on cell cycle progression and apoptosis. BMC Cell Biol (2004) 1.12
The major apoptotic pathway activated and suppressed by poliovirus. J Virol (2003) 1.08
dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ (2012) 1.07
Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling. J Virol (2012) 1.03
Neoplastic transformation and tumorigenesis associated with sam68 protein deficiency in cultured murine fibroblasts. J Biol Chem (2000) 1.03
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation. Cell Death Differ (2009) 0.97
Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase. FEBS Lett (2004) 0.97
Essential role of active nuclear transport in apoptosis. Genes Cells (1997) 0.97
Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport. J Virol (2009) 0.95
Evolution of Picornaviridae: an examination of phylogenetic relationships and cophylogeny. Mol Phylogenet Evol (2009) 0.94
dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects. J Interferon Cytokine Res (2014) 0.91
Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3. J Virol (2014) 0.90
Constitutive nuclear localization and initial cytoplasmic apoptotic activation of endogenous caspase-3 evidenced by confocal microscopy. Int J Exp Pathol (2003) 0.90
Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections. J Virol (2012) 0.87
The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. Virology (2012) 0.86
The nuclear pore complex, nuclear transport, and apoptosis. Can J Physiol Pharmacol (2006) 0.86
Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity. Cell Res (2010) 0.86
Nucleocytoplasmic transport in apoptosis. Cell Death Differ (2005) 0.86
Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells. PLoS One (2013) 0.85
A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. J Immunol (2014) 0.85
Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus. Front Microbiol (2015) 0.85
Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis. J Virol (2010) 0.84
Caspase-mediated inhibition of human cytosolic phospholipase A2 during apoptosis. J Immunol (1998) 0.84
The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nat Commun (2016) 0.83
Classification and evolution of human rhinoviruses. Methods Mol Biol (2015) 0.83
Apoptosis of infiltrating T cells in the central nervous system of mice infected with Theiler's murine encephalomyelitis virus. Virology (2003) 0.79
Nuclear Protein Sam68 Interacts with the Enterovirus 71 Internal Ribosome Entry Site and Positively Regulates Viral Protein Translation. J Virol (2015) 0.79
The nuclear protein Sam68 is redistributed to the cytoplasm and is involved in PI3K/Akt activation during EV71 infection. Virus Res (2013) 0.78
Variation in the nuclear effects of infection by different human rhinovirus serotypes. Front Microbiol (2015) 0.77
Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation. Genes Cells (2013) 0.76
Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections. Virol J (2015) 0.75
Sam68 is a regulator of Toll-like receptor signaling. Cell Mol Immunol (2016) 0.75