Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28929109)

Published in Biomed Res Int on August 27, 2017

Authors

Zili Zhang1, Jian Wang1,2, Zeguang Zheng1, Xindong Chen3, Xiansheng Zeng4, Yi Zhang5, Defu Li1, Jiaze Shu1, Kai Yang1, Ning Lai1, Lian Dong1, Wenju Lu1,2,6

Author Affiliations

1: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
2: Department of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3: Department of Respiratory Medicine, Lufeng People's Hospital, Lufeng, Guangdong, China.
4: Department of Respiratory Medicine, Xiangyang Central Hospital, Xiangyang, Hubei, China.
5: Department of Respiratory Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
6: Department of Laboratory Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.

Articles cited by this

Standardisation of spirometry. Eur Respir J (2005) 48.20

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86

Allelic discrimination using fluorogenic probes and the 5' nuclease assay. Genet Anal (1999) 9.80

Global burden of COPD: risk factors, prevalence, and future trends. Lancet (2007) 9.50

Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J (2012) 7.18

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07

Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov (2006) 5.30

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56

Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87

A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78

Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28

Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. PLoS Biol (2013) 2.08

Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06

Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res (2005) 1.97

Implications of reversibility testing on prevalence and risk factors for chronic obstructive pulmonary disease: a community study. Thorax (2005) 1.58

COPD: racial disparities in susceptibility, treatment, and outcomes. Clin Chest Med (2006) 1.54

Evidence for major genes influencing pulmonary function in the NHLBI family heart study. Genet Epidemiol (2000) 1.54

Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet (2009) 1.52

Identification of 15 loci influencing height in a Korean population. J Hum Genet (2009) 1.52

Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.51

Lung cancer gene associated with COPD: triple whammy or possible confounding effect? Eur Respir J (2008) 1.51

Obstructive lung disease and trypsin inhibitors in alpha-1-antitrypsin deficiency. Scand J Clin Lab Invest (1967) 1.46

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. Eur Respir J (2009) 1.16

Chromosome 4q31 locus in COPD is also associated with lung cancer. Eur Respir J (2010) 1.14

CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. Am J Respir Cell Mol Biol (2012) 1.13

Grading the severity of airways obstruction: new wine in new bottles. Eur Respir J (2013) 1.09

FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer. Appl Clin Genet (2010) 0.97

Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. PLoS One (2012) 0.96

From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development. Respir Res (2000) 0.96

Association of HHIP polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population. Gene (2013) 0.94

Comparative genomics on HHIP family orthologs. Int J Mol Med (2006) 0.90

Genes and chronic obstructive pulmonary disease. Med Clin North Am (2012) 0.88

SnapShot: hedgehog signaling pathway. Cell (2007) 0.87

Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease. Respirology (2013) 0.83

Association of FAM13A polymorphisms with COPD and COPD-related phenotypes in Han Chinese. Clin Biochem (2013) 0.81

A genome-wide association study of chronic obstructive pulmonary disease in Hispanics. Ann Am Thorac Soc (2015) 0.81

Letter: Natural history of chronic bronchitis. Br Med J (1976) 0.80

Genetic variants in MUC4 gene are associated with lung cancer risk in a Chinese population. PLoS One (2013) 0.78

Study Design and Interim Outcomes of Guangzhou Institute of Respiratory Disease COPD Biobank. COPD (2015) 0.76