DNA priming increases frequency of T-cell responses to a VSV HIV vaccine with specific enhancement of CD8(+) T-cell responses by IL-12 pDNA.

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Published in Clin Vaccine Immunol on September 20, 2017

Authors

Shuying S Li1, Nidhi K Kochar1, Marnie Elizaga1, Christine M Hay2, Gregory J Wilson3, Kristen W Cohen1, Stephen C De Rosa1,4, Rong Xu5, Ayuko Ota-Setlik5, Daryl Morris1, Greg Finak1, Mary Allen6, Hong-Van Tieu7, Ian Frank8, Magdalena E Sobieszczyk9, Drew Hannaman10, Raphael Gottardo1, Peter B Gilbert1, Georgia D Tomaras11, Lawrence Corey1,4, David K Clarke5, Michael A Egan5, John H Eldridge5, M Juliana McElrath1,4,4,4, Nicole Frahm12,4, NIAID HIV Vaccine Trials Network

Author Affiliations

1: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
2: Infectious Diseases Division, University of Rochester Medical Center, Rochester, New York, USA.
3: Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
4: Departments of Laboratory Medicine, Medicine and Global Health, University of Washington, Seattle, Washington, USA.
5: Profectus BioSciences, Tarrytown, New York, USA.
6: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
7: Laboratory of Infectious Disease Prevention, New York Blood Center, New York, New York, USA.
8: Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
9: Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA.
10: Ichor Medical Systems, Inc., San Diego, California, USA.
11: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
12: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA nfrahm@fredhutch.org.

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