Protective Cytomegalovirus (CMV)-Specific T-Cell Immunity Is Frequent in Kidney Transplant Patients without Serum Anti-CMV Antibodies.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28955345)

Published in Front Immunol on September 12, 2017

Authors

Nicolle H R Litjens1, Ling Huang1, Burç Dedeoglu1, Ruud W J Meijers1, Jaap Kwekkeboom2, Michiel G H Betjes1

Author Affiliations

1: Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
2: Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

Articles cited by this

The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med (1998) 4.80

Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00

Epidemiology of cytomegalovirus infection after transplantation and immunosuppression. J Infect Dis (1975) 3.02

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes. J Exp Med (1989) 2.89

Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol (2002) 2.65

Cell-mediated immunity to predict cytomegalovirus disease in high-risk solid organ transplant recipients. Am J Transplant (2009) 2.25

Hepatitis B vaccine in patients receiving hemodialysis. Immunogenicity and efficacy. N Engl J Med (1984) 1.93

Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J Immunol (2004) 1.89

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Opin Immunol (2009) 1.51

Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients. J Am Soc Nephrol (2008) 1.46

Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. Blood (2001) 1.40

Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection. Blood (2006) 1.40

Functional subsets of memory T cells identified by CCR7 expression. Curr Top Microbiol Immunol (2000) 1.39

Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans. Proc Natl Acad Sci U S A (2005) 1.30

Assessment of cytomegalovirus-specific cell-mediated immunity for the prediction of cytomegalovirus disease in high-risk solid-organ transplant recipients: a multicenter cohort study. Clin Infect Dis (2012) 1.25

Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in French haemodialysis units: I, Medical staff. Lancet (1981) 1.21

Premature aging of circulating T cells in patients with end-stage renal disease. Kidney Int (2011) 1.21

Expansion of cytolytic CD4+CD28- T cells in end-stage renal disease. Kidney Int (2008) 1.16

Is the cytomegalovirus serologic status always accurate? A comparative analysis of humoral and cellular immunity. Transplantation (2003) 1.08

Tetanus immunization and its association to hepatitis B vaccination in patients with chronic renal failure. Am J Kidney Dis (1995) 1.07

IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells. J Immunol (2008) 1.06

Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection. J Immunol (1999) 1.02

Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets. Immun Ageing (2011) 0.96

Clinical assessment of anti-viral CD8+ T cell immune monitoring using QuantiFERON-CMV® assay to identify high risk allogeneic hematopoietic stem cell transplant patients with CMV infection complications. PLoS One (2013) 0.95

Transient oral human cytomegalovirus infections indicate inefficient viral spread from very few initially infected cells. J Virol (2017) 0.94

Viral inoculum dose impacts memory T-cell inflation. Eur J Immunol (2014) 0.90

High risk of cytomegalovirus infection following solid organ transplantation despite prophylactic therapy. J Med Virol (2013) 0.89

Primary Cytomegalovirus Infection Significantly Impacts Circulating T Cells in Kidney Transplant Recipients. Am J Transplant (2015) 0.87

Preformed frequencies of cytomegalovirus (CMV)-specific memory T and B cells identify protected CMV-sensitized individuals among seronegative kidney transplant recipients. Clin Infect Dis (2014) 0.87

Hepatitis B vaccine-specific CD4(+) T cells can be detected and characterised at the single cell level: limited usefulness of dendritic cells as signal enhancers. J Immunol Methods (2007) 0.86

Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells. Clin Exp Immunol (2013) 0.84

Kinetics of homeostatic proliferation and thymopoiesis after rATG induction therapy in kidney transplant patients. Transplantation (2013) 0.83

Cytomegalovirus contributes partly to uraemia-associated premature immunological ageing of the T cell compartment. Clin Exp Immunol (2013) 0.83

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival. J Exp Med (2016) 0.83

An optimized IFN-γ ELISpot assay for the sensitive and standardized monitoring of CMV protein-reactive effector cells of cell-mediated immunity. BMC Immunol (2017) 0.78