Published in Biochem Biophys Rep on January 05, 2017
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science (2002) 9.90
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res (2011) 4.90
DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun (1997) 3.61
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A (2006) 3.41
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. Nature (1998) 2.44
The cystatins: protein inhibitors of cysteine proteinases. FEBS Lett (1991) 2.33
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J Biol Chem (2001) 2.16
An asparaginyl endopeptidase mediates in vivo protein backbone cyclization. J Biol Chem (2007) 1.77
DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem (2006) 1.68
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet (2005) 1.66
DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J Biol Chem (2007) 1.59
DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol Cancer Res (2003) 1.53
Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site. J Biol Chem (1999) 1.52
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol (2005) 1.50
DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. Int J Oncol (2005) 1.39
Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. J Biol Chem (2003) 1.36
Cloning and expression of mouse legumain, a lysosomal endopeptidase. Biochem J (1998) 1.16
DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res (2007) 1.15
Legumain: asparaginyl endopeptidase. Methods Enzymol (1994) 1.12
Activation of human prolegumain by cleavage at a C-terminal asparagine residue. Biochem J (2000) 1.11
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis. Cancer Immunol Immunother (2007) 1.08
Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells. FEBS Lett (2007) 1.06
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer. J Cell Biochem (2012) 1.06
Cystatin superfamily. J Health Care Poor Underserved (2010) 1.05
DJ-1, a target protein for an endocrine disrupter, participates in the fertilization in mice. Biol Pharm Bull (2002) 1.02
SP22: a novel fertility protein from a highly conserved gene family. J Androl (1998) 1.01
Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. J Immunol (2004) 1.01
Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxid Redox Signal (2009) 0.99
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.98
Shedding of a rat epididymal sperm protein associated with infertility induced by ornidazole and alpha-chlorohydrin. Biol Reprod (1998) 0.95
Nuclear legumain activity in colorectal cancer. PLoS One (2013) 0.95
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS One (2012) 0.94
Autocatalytic activation of human legumain at aspartic acid residues. FEBS Lett (1998) 0.94
Association of legumain expression pattern with prostate cancer invasiveness and aggressiveness. World J Urol (2012) 0.94
Proteomic analysis of seminal plasma from asthenozoospermia patients reveals proteins that affect oxidative stress responses and semen quality. Asian J Androl (2009) 0.93
Localization of the sperm protein SP22 and inhibition of fertility in vivo and in vitro. J Androl (2002) 0.93
Expression and cellular localization of contraception-associated protein. J Androl (2001) 0.92
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res (2014) 0.91
Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M. Biochimie (2012) 0.90
Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Res Rev (2004) 0.89
Immunocytochemical localization of DJ-1 in human male reproductive tissue. Mol Reprod Dev (2003) 0.88
Effects of legumain as a potential prognostic factor on gastric cancers. Med Oncol (2013) 0.88
Legumain from bovine kidney: its purification, molecular cloning, immunohistochemical localization and degradation of annexin II and vitamin D-binding protein. Biochim Biophys Acta (2002) 0.86
Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene. J Biol Chem (2010) 0.86
Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain. Angew Chem Int Ed Engl (2015) 0.83
Structure and function of legumain in health and disease. Biochimie (2015) 0.82
Transcriptional regulation of the legumain gene by p53 in HCT116 cells. Biochem Biophys Res Commun (2013) 0.81
Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney. Biochem Biophys Res Commun (2012) 0.79
Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice. PLoS One (2013) 0.78
Characterisation of the QM gene of Trypanosoma brucei. FEMS Microbiol Lett (2002) 0.78
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells. Biochem Biophys Res Commun (2015) 0.77
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells. Biochem Biophys Res Commun (2015) 0.77
Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice. Biochem Biophys Res Commun (2015) 0.75
Deficiency of spermatogenesis and reduced expression of spermatogenesis-related genes in prefoldin 5-mutant mice. Biochem Biophys Rep (2015) 0.75