Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28962641)

Published in Stem Cell Res Ther on September 29, 2017

Authors

Victor G Martinez1, Imelda Ontoria-Oviedo2, Carolina P Ricardo3, Sian E Harding3, Rosa Sacedon4, Alberto Varas4, Agustin Zapata5, Pilar Sepulveda2, Angeles Vicente6

Author Affiliations

1: MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. v.martinez@ucl.ac.uk.
2: Instituto de Investigación Sanitaria La Fe, Regenerative Medicine and Heart Transplantation Unit, Valencia, Spain.
3: National Heart and Lung Institute, Imperial College, London, UK.
4: Department of Cell Biology, Faculty of Medicine, Complutense University, Plaza de Ramón y Cajal, 28040, Madrid, Spain.
5: Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain.
6: Department of Cell Biology, Faculty of Medicine, Complutense University, Plaza de Ramón y Cajal, 28040, Madrid, Spain. avicente@ucm.es.

Articles cited by this

Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol (2009) 8.67

Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49

Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation (2002) 7.97

Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A (2005) 6.16

Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med (2006) 4.53

Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood (2005) 3.37

Regulation of the inflammatory response in cardiac repair. Circ Res (2012) 3.21

Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock (2006) 2.61

Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol (2009) 2.37

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol (2004) 2.12

Cellular ligands of activating NK receptors. Trends Immunol (2005) 1.84

Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice. PLoS One (2014) 1.83

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods (2011) 1.78

Mesenchymal stem cell effects on T-cell effector pathways. Stem Cell Res Ther (2011) 1.76

Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells (2007) 1.68

IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ Res (2006) 1.61

Allogeneic periodontal ligament stem cell therapy for periodontitis in swine. Stem Cells (2010) 1.40

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. J Immunol (2009) 1.32

Effects of Hypoxia on the Immunomodulatory Properties of Adipose Tissue-Derived Mesenchymal Stem cells. Front Immunol (2013) 1.11

Human oral mucosa and gingiva: a unique reservoir for mesenchymal stem cells. J Dent Res (2012) 1.09

Brief report--human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes. Stem Cells (2009) 1.07

Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci (2015) 1.01

Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair. Stem Cells Dev (2012) 1.01

Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms. Stem Cells (2011) 0.98

Hypoxic preconditioning of mesenchymal stromal cells induces metabolic changes, enhances survival, and promotes cell retention in vivo. Stem Cells (2015) 0.96

RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans. Angiogenesis (2012) 0.95

Immunomodulatory and potential therapeutic role of mesenchymal stem cells in periodontitis. J Physiol Pharmacol (2014) 0.92

Immunomodulatory properties of dental tissue-derived mesenchymal stem cells. Oral Dis (2013) 0.89

Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner. Int J Oncol (2012) 0.87

Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions. Scand J Immunol (2003) 0.87

Mesenchymal Stem Cells Derived from Dental Pulp: A Review. Stem Cells Int (2015) 0.86

A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates: Paracrine Activity Without Remuscularization. Circ Res (2016) 0.85

Analyzing and interpreting genome data at the network level with ConsensusPathDB. Nat Protoc (2016) 0.84

Preclinical evaluation of the engineered stem cell chemokine stromal cell-derived factor 1α analog in a translational ovine myocardial infarction model. Circ Res (2013) 0.83

Enhancement of angiogenic effects by hypoxia-preconditioned human umbilical cord-derived mesenchymal stem cells in a mouse model of hindlimb ischemia. Cell Biol Int (2015) 0.80

The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. PLoS One (2015) 0.80

Effects of hypoxia on the immunomodulatory properties of human gingiva-derived mesenchymal stem cells. J Dent Res (2014) 0.80

The problem is obvious, the solution is not: numbers do matter in cardiac cell therapy! Cardiovasc Res (2012) 0.78

Should hypoxia preconditioning become the standardized procedure for bone marrow MSCs preparation for clinical use? Stem Cells (2016) 0.78

Knockdown of the interleukin-6 receptor alpha chain of dendritic cell vaccines enhances the therapeutic potential against IL-6 producing tumors. Vaccine (2010) 0.77

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs). J Vis Exp (2015) 0.77