Published in Cytokine Growth Factor Rev on September 23, 2017
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature (2003) 20.48
Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer (2010) 8.55
Receptor specificity of the fibroblast growth factor family. J Biol Chem (1996) 7.58
Fibroblast growth factors. Genome Biol (2001) 7.32
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest (2007) 6.56
The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer (2005) 5.07
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med (2006) 3.84
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol Cell Biol (1992) 3.41
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells (2005) 2.78
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev (2008) 2.40
Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci (2004) 2.27
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J Mol Cell Cardiol (2000) 2.25
Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature (1997) 2.03
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease? J Cell Commun Signal (2009) 2.00
Fibroblast growth factor reversal of the corneal myofibroblast phenotype. Invest Ophthalmol Vis Sci (2001) 1.95
The Fibroblast Growth Factor signaling pathway. Wiley Interdiscip Rev Dev Biol (2015) 1.82
Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol (1996) 1.79
MicroRNAs and the regulation of fibrosis. FEBS J (2010) 1.79
Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells (2006) 1.77
Connective tissue growth factor and cardiac fibrosis after myocardial infarction. J Histochem Cytochem (2005) 1.62
Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene (2000) 1.57
Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. J Biol Chem (1992) 1.53
Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair. Cytokine (2000) 1.48
Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair. J Pediatr Surg (2000) 1.47
Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair Regen (2011) 1.47
Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatol Res (2003) 1.46
A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells. Stem Cells (2009) 1.46
Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J Biol Chem (2005) 1.45
Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6. J Invest Dermatol (1991) 1.45
Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts. J Biol Chem (1999) 1.39
Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. J Rheumatol (2000) 1.38
Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells. FASEB J (2008) 1.37
Recombinant basic fibroblast growth factor accelerates wound healing. J Surg Res (1988) 1.29
MicroRNAs and fibrosis. Curr Opin Nephrol Hypertens (2012) 1.28
Transforming growth factor-{beta}-inducible phosphorylation of Smad3. J Biol Chem (2009) 1.28
Fibroblasts and myofibroblasts: what are we talking about? J Cardiovasc Pharmacol (2011) 1.25
MicroRNAs in common human diseases. Genomics Proteomics Bioinformatics (2012) 1.25
p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation. J Biol Chem (1999) 1.24
FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation. Development (2012) 1.22
Basic fibroblast growth factor mediates angiogenic activity in early surgical wounds. Surgery (1996) 1.20
Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I. Cell Death Dis (2011) 1.19
FGF-1 reverts epithelial-mesenchymal transition induced by TGF-{beta}1 through MAPK/ERK kinase pathway. Am J Physiol Lung Cell Mol Physiol (2010) 1.19
Site-specific production of TGF-beta in oral mucosal and cutaneous wounds. Wound Repair Regen (2007) 1.17
Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcohol Clin Exp Res (1999) 1.17
The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation. J Biol Chem (2010) 1.15
Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters. Circulation (2000) 1.15
Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy. J Mol Cell Cardiol (2004) 1.14
FGF-2 antagonizes the TGF-beta1-mediated induction of pericyte alpha-smooth muscle actin expression: a role for myf-5 and Smad-mediated signaling pathways. Invest Ophthalmol Vis Sci (2003) 1.13
Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2. Circ Res (2003) 1.13
The high molecular weight isoforms of basic fibroblast growth factor (FGF-2): an insight into an intracrine mechanism. FEBS Lett (2000) 1.11
Basic fibroblast growth factor promotes apoptosis and suppresses granulation tissue formation in acute incisional wounds. J Pathol (2004) 1.09
The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo. PLoS One (2013) 1.08
Fibroblast growth factor 2 induces E-cadherin down-regulation via PI3K/Akt/mTOR and MAPK/ERK signaling in ovarian cancer cells. PLoS One (2013) 1.07
Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer. Eur J Cancer (2013) 1.07
Basic fibroblast growth factor accelerates and improves second-degree burn wound healing. Wound Repair Regen (2009) 1.07
Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7. Gastroenterology (2008) 1.04
The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling. J Mol Cell Cardiol (2006) 1.04
Fibroblast growth factor signaling in skeletal development and disease. Genes Dev (2015) 1.04
Opposing roles of ERK and p38 MAP kinases in FGF2-induced astroglial process extension. Mol Cell Neurosci (2005) 1.03
IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol (2006) 1.03
FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling. FEBS Lett (2009) 1.02
α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy. Cardiovasc Res (2012) 1.02
Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-AP1 element. Mol Endocrinol (1997) 1.00
Interleukin-6 (IL-6) modulates migration and matrix metalloproteinase function in dermal fibroblasts from IL-6KO mice. Br J Dermatol (2007) 0.99
Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: upregulation of MMP-1 and HGF expression. Lab Invest (2011) 0.97
TGF-β3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats. Dis Model Mech (2013) 0.97
Myofibroblasts. Exp Eye Res (2015) 0.97
The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar. J Invest Dermatol (2013) 0.97
Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. Mol Brain (2009) 0.97
Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. Arthritis Rheum (2007) 0.96
The myofibroblast, multiple origins for major roles in normal and pathological tissue repair. Fibrogenesis Tissue Repair (2012) 0.95
Smad linker region phosphorylation in the regulation of extracellular matrix synthesis. Cell Mol Life Sci (2010) 0.95
Basic fibroblast growth factor reduces scar formation in acute incisional wounds. Wound Repair Regen (2007) 0.95
MicroRNAs in fibrosis: opportunities and challenges. Arthritis Res Ther (2016) 0.93
Regulation of human interstitial collagenase (matrix metalloproteinase-1) promoter activity by fibroblast growth factor. Eur J Biochem (1997) 0.93
Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification. Cancer Res (2010) 0.93
Unconventional secretion of fibroblast growth factor 2--a novel type of protein translocation across membranes? J Mol Biol (2014) 0.92
Connective tissue growth factor in retrocorneal membranes and corneal scars. Ophthalmologica (2000) 0.92
Antifibrotic effect of hepatocyte growth factor-expressing mesenchymal stem cells in small-for-size liver transplant rats. Stem Cells Dev (2010) 0.92
Growth factor, cytokine and protease interactions during corneal wound healing. Ocul Surf (2003) 0.91
Basic fibroblast growth factor induces down-regulation of alpha-smooth muscle actin and reduction of myofibroblast areas in open skin wounds. Wound Repair Regen (2009) 0.91
The effect of basic fibroblast growth factor on scarring. Br J Plast Surg (2002) 0.91
TGF-β-stimulated CTGF production enhanced by collagen and associated with biogenesis of a novel 31-kDa CTGF form in human corneal fibroblasts. Invest Ophthalmol Vis Sci (2010) 0.90
Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol (2009) 0.90
Transforming growth factor-β-induced differentiation of airway smooth muscle cells is inhibited by fibroblast growth factor-2. Am J Respir Cell Mol Biol (2012) 0.90
TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing. Mol Pathol (2002) 0.89
FGF2-induced effects on transcriptome associated with regeneration competence in adult human fibroblasts. BMC Genomics (2013) 0.88
Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer. Oncogene (2015) 0.88
Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor. J Biol Chem (2013) 0.88
Antifibrotic effects of hepatocyte growth factor on scleroderma fibroblasts and analysis of its mechanism. Mod Rheumatol (2006) 0.87
The quality of pediatric burn scars is improved by early administration of basic fibroblast growth factor. J Burn Care Res (2006) 0.87
Basic fibroblast growth factor: a potential new therapeutic tool for the treatment of hypertrophic and keloid scars. Ann Anat (2008) 0.87
The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner. Matrix Biol (2009) 0.87
FGF2-induced Ras-MAPK signalling maintains lymphatic endothelial cell identity by upregulating endothelial-cell-specific gene expression and suppressing TGFβ signalling through Smad2. J Cell Sci (2013) 0.86
A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS One (2009) 0.86
Mechanism of FGF receptor dimerization and activation. Nat Commun (2016) 0.86