Logic Synthesis of Recombinase-Based Genetic Circuits.

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A synthetic oscillatory network of transcriptional regulators. Nature (2000) 24.58

Construction of a genetic toggle switch in Escherichia coli. Nature (2000) 24.02

Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods (2009) 22.47

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37

Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science (2014) 10.43

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55

A fast, robust and tunable synthetic gene oscillator. Nature (2008) 6.85

In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase family. Proc Natl Acad Sci U S A (1998) 5.04

Synthetic gene networks that count. Science (2009) 4.54

Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'. Nature (2010) 3.69

Amplifying genetic logic gates. Science (2013) 3.33

A synthetic gene-metabolic oscillator. Nature (2005) 3.26

Synthetic circuits integrating logic and memory in living cells. Nat Biotechnol (2013) 2.62

Genetic programs constructed from layered logic gates in single cells. Nature (2012) 2.35

Synthetic gene network for entraining and amplifying cellular oscillations. Phys Rev Lett (2002) 2.24

Distributed biological computation with multicellular engineered networks. Nature (2010) 2.13

Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology. Nat Commun (2011) 2.06

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The orientation of mycobacteriophage Bxb1 integration is solely dependent on the central dinucleotide of attP and attB. Mol Cell (2003) 1.86

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Phage R4 integrase mediates site-specific integration in human cells. Gene (2001) 1.71

Integration and excision by the large serine recombinase phiRv1 integrase. Mol Microbiol (2005) 1.43

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A diversity of serine phage integrases mediate site-specific recombination in mammalian cells. Mol Genet Genomics (2006) 1.26

Genome analysis of an inducible prophage and prophage remnants integrated in the Streptococcus pyogenes strain SF370. Virology (2002) 1.23

Resolvase-like recombination performed by the TP901-1 integrase. Microbiology (2001) 1.20

Serine recombinases as tools for genome engineering. Methods (2010) 1.13

Quantifying cellular capacity identifies gene expression designs with reduced burden. Nat Methods (2015) 1.11

Synthetic recombinase-based state machines in living cells. Science (2016) 1.10

Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates. Sci Transl Med (2015) 0.97

Site-specific recombination in Schizosaccharomyces pombe and systematic assembly of a 400kb transgene array in mammalian cells using the integrase of Streptomyces phage phiBT1. Nucleic Acids Res (2007) 0.93

Construction of an integration-proficient vector based on the site-specific recombination mechanism of enterococcal temperate phage phiFC1. J Bacteriol (2002) 0.88

A novel site-specific recombination system derived from bacteriophage phiMR11. Biochem Biophys Res Commun (2008) 0.85

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells. Nat Biotechnol (2017) 0.85

In vitro characterization of the site-specific recombination system based on actinophage TG1 integrase. Mol Genet Genomics (2009) 0.84

Isocost Lines Describe the Cellular Economy of Genetic Circuits. Biophys J (2015) 0.83

Unique nucleotide sequence-guided assembly of repetitive DNA parts for synthetic biology applications. Nat Protoc (2014) 0.83

Using synthetic biological parts and microbioreactors to explore the protein expression characteristics of Escherichia coli. ACS Synth Biol (2013) 0.81

Engineering multicellular logic in bacteria with metabolic wires. ACS Synth Biol (2013) 0.80

A Minimal Model of Ribosome Allocation Dynamics Captures Trade-offs in Expression between Endogenous and Synthetic Genes. ACS Synth Biol (2016) 0.80

Multilevel Regulation and Translational Switches in Synthetic Biology. IEEE Trans Biomed Circuits Syst (2015) 0.77