Information theory, evolutionary innovations and evolvability.

The evolutionary significance of cis-regulatory mutations. Nat Rev Genet (2007) 9.35

Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07

In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol (2001) 8.88

Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci U S A (2002) 8.41

Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res (2003) 7.22

In vitro selection of functional nucleic acids. Annu Rev Biochem (1999) 6.55

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox. Nat Protoc (2007) 6.24

From sequences to shapes and back: a case study in RNA secondary structures. Proc Biol Sci (1994) 6.01

Reconstruction of biochemical networks in microorganisms. Nat Rev Microbiol (2008) 5.36

Non-globular domains in protein sequences: automated segmentation using complexity measures. Comput Chem (1994) 4.36

Plasticity, evolvability, and modularity in RNA. J Exp Zool (2000) 3.98

Emerging principles of regulatory evolution. Proc Natl Acad Sci U S A (2007) 3.42

Continuity in evolution: on the nature of transitions. Science (1998) 3.40

Exploring protein fitness landscapes by directed evolution. Nat Rev Mol Cell Biol (2009) 3.13

Robustness and evolvability: a paradox resolved. Proc Biol Sci (2008) 3.08

Determination and inference of eukaryotic transcription factor sequence specificity. Cell (2014) 2.84

Functional proteins from a random-sequence library. Nature (2001) 2.81

Development of floral organ identity: stories from the MADS house. Curr Opin Plant Biol (2001) 2.79

Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme. Nature (2011) 2.63

Modeling regulatory networks with weight matrices. Pac Symp Biocomput (1999) 2.52

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing. Proc Natl Acad Sci U S A (2012) 2.47

Evolution of biological complexity. Proc Natl Acad Sci U S A (2000) 2.32

Informational complexity and functional activity of RNA structures. J Am Chem Soc (2004) 2.19

The Beagle in a bottle. Nature (2009) 2.11

Adaptive evolution of transcription factor binding sites. BMC Evol Biol (2004) 2.03

Modelling neutral and selective evolution of protein folding. Proc Biol Sci (1991) 1.86

The robustness and evolvability of transcription factor binding sites. Science (2014) 1.76

Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently. Chem Soc Rev (2015) 1.74

Analyses of the effects of all ubiquitin point mutants on yeast growth rate. J Mol Biol (2013) 1.59

Evolutionary plasticity and innovations in complex metabolic reaction networks. PLoS Comput Biol (2009) 1.43

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proc Natl Acad Sci U S A (2012) 1.39

Functional information: Molecular messages. Nature (2003) 1.30

Free fitness that always increases in evolution. J Theor Biol (1988) 1.23

Abundant indispensable redundancies in cellular metabolic networks. Genome Biol Evol (2009) 1.23

Gene duplications, robustness and evolutionary innovations. Bioessays (2008) 1.21

Protein robustness promotes evolutionary innovations on large evolutionary time-scales. Proc Biol Sci (2008) 1.16

The fitness value of information. Oikos (2010) 1.02

Natural selection. V. How to read the fundamental equations of evolutionary change in terms of information theory. J Evol Biol (2012) 1.00

Comprehensive experimental fitness landscape and evolutionary network for small RNA. Proc Natl Acad Sci U S A (2013) 1.00

A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure. J R Soc Interface (2014) 0.96

Epistasis can lead to fragmented neutral spaces and contingency in evolution. Proc Biol Sci (2011) 0.94

When unreliable cues are good enough. Am Nat (2013) 0.92

A theory of pragmatic information and its application to the quasi-species model of biological evolution. Biosystems (2002) 0.90

The disadvantage of combinatorial communication. Proc Biol Sci (2004) 0.88

Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization. Biochemistry (2009) 0.83

From bit to it: how a complex metabolic network transforms information into living matter. BMC Syst Biol (2007) 0.82

Synthetic shuffling and in vitro selection reveal the rugged adaptive fitness landscape of a kinase ribozyme. RNA (2013) 0.81

Evolutionary dynamics, epistatic interactions, and biological information. J Theor Biol (2010) 0.81

Population genetics from an information perspective. J Theor Biol (2001) 0.81

Exhaustive Analysis of a Genotype Space Comprising 10(15 )Central Carbon Metabolisms Reveals an Organization Conducive to Metabolic Innovation. PLoS Comput Biol (2015) 0.79

Information Theory, Scaling Laws and the Thermodynamics of Evolution. J Theor Biol (1998) 0.78

Evolution on neutral networks accelerates the ticking rate of the molecular clock. J R Soc Interface (2015) 0.77

Dynamics of Transcription Factor Binding Site Evolution. PLoS Genet (2015) 0.77

Biological information: why we need a good measure and the challenges ahead. Interface Focus (2013) 0.77

A thousand empirical adaptive landscapes and their navigability. Nat Ecol Evol (2017) 0.77

Information entropy as a measure of genetic diversity and evolvability in colonization. Mol Ecol (2015) 0.76

Innovation: an emerging focus from cells to societies. Philos Trans R Soc Lond B Biol Sci (2017) 0.75

Non-adaptive origins of evolutionary innovations increase network complexity in interacting digital organisms. Philos Trans R Soc Lond B Biol Sci (2017) 0.75