PubRank

D Ayusawa

Author PubWeight™ 69.18‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature 1998 4.06
2 Pleiotropic phenomena in autolytic enzyme(s) content, flagellation, and simultaneous hyperproduction of extracellular alpha-amylase and protease in a Bacillus subtilis mutant. J Bacteriol 1975 2.78
3 Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucleic Acids Res 1985 2.08
4 Molecular cloning of genomic DNA segments partially coding for human thymidylate synthase from the mouse cell transformant. J Biochem 1984 1.99
5 Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J Biol Chem 1987 1.64
6 Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate. J Mol Biol 1986 1.51
7 Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem 1990 1.43
8 Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA. Nucleic Acids Res 1987 1.25
9 Construction of a normalized cDNA library by introduction of a semi-solid mRNA-cDNA hybridization system. Nucleic Acids Res 1994 1.25
10 Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator. J Biochem 1996 1.21
11 Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells. J Biol Chem 1983 1.20
12 Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol 1993 1.18
13 Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity. Biochem Biophys Res Commun 1998 1.08
14 Chromosome breakage induced by thymidylate stress in thymidylate synthase-negative mutants of mouse FM3A cells. Cancer Res 1984 1.07
15 Cyclin I: a new cyclin encoded by a gene isolated from human brain. Exp Cell Res 1995 1.02
16 Unusual aspects of human thymidylate synthase in mouse cells introduced by DNA-mediated gene transfer. J Biol Chem 1983 1.02
17 A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans. DNA Res 1998 1.01
18 Isolation of functional cDNA clones for human thymidylate synthase. J Biol Chem 1984 0.99
19 N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. Oncogene 1996 0.98
20 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species. J Biochem 1999 0.97
21 Conditional thymidine auxotrophic mutants of mouse FM3A cells due to thermosensitive thymidylate synthase and their prototrophic revertants. J Biol Chem 1981 0.97
22 Human thymidylate synthase gene: isolation of phage clones which cover a functionally active gene and structural analysis of the region upstream from the translation initiation codon. J Biochem 1989 0.96
23 Cloning and sequence of a functionally active cDNA encoding the mouse ubiquitin-activating enzyme E1. Gene 1992 0.96
24 Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells. Cancer Res 1981 0.94
25 Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1. Exp Cell Res 1997 0.93
26 Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells. Exp Gerontol 2001 0.92
27 Selection of mammalian thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate. Somatic Cell Genet 1981 0.91
28 Thymineless death and genetic events in mammalian cells. Basic Life Sci 1985 0.91
29 Single-step selection of mouse FM3A cell mutants defective in thymidylate synthetase. Somatic Cell Genet 1980 0.90
30 Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridization. Hum Genet 1990 0.90
31 Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells. Mol Cell Biol 1986 0.90
32 The human ubiquitin-activating enzyme E1 gene (UBE1) mapped to band Xp11.3----p11.23 by fluorescence in situ hybridization. Cytogenet Cell Genet 1992 0.89
33 Intron 1 and the 5'-flanking region of the human thymidylate synthase gene as a regulatory determinant of growth-dependent expression. Nucleic Acids Res 1992 0.89
34 Alteration of ribonucleotide reductase in aphidicolin-resistant mutants of mouse FM3A cells with associated resistance to arabinosyladenine and arabinosylcytosine. Somatic Cell Genet 1981 0.88
35 Introduction of chromosome 7 suppresses telomerase with shortening of telomeres in a human mesothelial cell line. Exp Cell Res 1999 0.87
36 Identification of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells. J Biol Chem 2000 0.87
37 Expression of fragile site on the human X chromosome in somatic cell hybrids between human fragile X cells and thymidylate synthase-negative mouse mutant cells. Jpn J Cancer Res 1985 0.86
38 The cytotoxicity of 5-fluorouracil is due to its incorporation into RNA not its inhibition of thymidylate synthase as evidenced by the use of a mouse cell mutant deficient in thymidylate synthase. Jpn J Cancer Res 1986 0.85
39 Thymidylate stress induces homologous recombination activity in mammalian cells. Mutat Res 1991 0.82
40 Assignment of human gene encoding thymidylate synthase to chromosome 18 using interspecific cell hybrids between thymidylate synthase-negative mouse mutant cells and human diploid fibroblasts. Somat Cell Mol Genet 1985 0.82
41 Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene. Mol Pharmacol 1987 0.82
42 Increase in dATP pool in aphidicolin-resistant mutants of mouse FM3A cells. Biochem Biophys Res Commun 1979 0.82
43 DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblasts. Biochem Biophys Res Commun 1998 0.82
44 Genetic complementation of the immortal phenotype in group D cell lines by introduction of chromosome 7. Jpn J Cancer Res 1995 0.81
45 Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene. Jpn J Cancer Res 1985 0.80
46 Isolation of mouse FM3A cell mutants with thermolabile thymidylate synthetase by resistance to aphidicolin. Biochem Biophys Res Commun 1980 0.80
47 Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene. Cell Struct Funct 1986 0.80
48 Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. FEBS Lett 1985 0.80
49 The introduction of dominant-negative p53 mutants suppresses temperature shift-induced senescence in immortal human fibroblasts expressing a thermolabile SV40 large T antigen. J Biochem 1999 0.79
50 Regulatory sequences clustered at the 5' end of the first intron of the human thymidylate synthase gene function in cooperation with the promoter region. Somat Cell Mol Genet 1992 0.79
51 Aphidicolin-resistant mutants of mouse lymphoma L5178Y cells with a high incidence of spontaneous sister chromatid exchanges. Genetics 1986 0.79
52 Unusual sensitivity to bleomycin and joint resistance to 9-beta-D-arabinofuranosyladenine and 1-beta-D-arabinofuranosylcytosine of mouse FM3A cell mutants with altered ribonucleotide reductase and thymidylate synthase. Cancer Res 1983 0.79
53 Thymidineless death and mutation induction in cultured mouse FM3A cell mutants deficient in thymidylate synthase. Mutat Res 1982 0.79
54 Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. FEBS Lett 1995 0.78
55 Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds. Anticancer Res 1987 0.78
56 Purification and NH2-terminal amino acid sequence of human thymidylate synthase in an overproducing transformant of mouse FM3A cells. J Biochem 1985 0.78
57 Identification and characterization of an L1 family sequence with a very long open reading frame in the third intron of the human thymidylate synthase gene. J Biochem 1989 0.78
58 The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus. Somat Cell Mol Genet 1993 0.78
59 Two types of mouse FM3A cell mutants deficient in 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and their transformants isolated by human chromosome-mediated gene transfer. Somat Cell Mol Genet 1989 0.78
60 Thymidylate stress and sister chromatid exchanges. Basic Life Sci 1984 0.78
61 5-Bromodeoxyuridine suppresses position effect variegation of transgenes in HeLa cells. Exp Cell Res 2001 0.78
62 Effect of tunicamycin on molecular heterogeneity of colony stimulating factor in cultured mouse mammary carcinoma FM3A cells. Biochem Biophys Res Commun 1979 0.78
63 Suppression of senescence in normal human fibroblasts by introduction of dominant-negative p53 mutants or human papilloma virus type 16 E6 protein. Biosci Biotechnol Biochem 1998 0.77
64 Thymidylate synthetase-deficient mouse FM3A mammary carcinoma cell line as a tool for studying the thymidine salvage pathway and the incorporation of thymidine analogues into host cell DNA. Biochem J 1984 0.77
65 Incorporation of 5-substituted pyrimidine nucleoside analogues into DNA of a thymidylate synthetase-deficient murine FM3A carcinoma cell line. Methods Find Exp Clin Pharmacol 1985 0.77
66 Tunicamycin-resistant mutations in mouse FM3A cells. Mutat Res 1982 0.77
67 Defective DNA replication and repair associated with decreases in deoxyribonucleotide pools in a mouse cell mutant with thermolabile ubiquitin-activating enzyme E1. J Biochem 1999 0.76
68 Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene. Mol Pharmacol 1985 0.76
69 A panel of radiation hybrids defining the 7q31-q32 region of human chromosome 7. DNA Res 1996 0.75
70 Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts. Oncogene 1995 0.75
71 Effect of tunicamycin on production by mouse fibroblast L929 cells of the factor-stimulating differentiation of mouse myeloid leukemic cells and the colony-stimulating factor. Cancer Res 1981 0.75
72 [Biochemical modulation of 5-FU by thymidine and N-phosphoacetyl-L-aspartate: the relation between 5-FU incorporation into RNA and its cytocidal effect]. Gan To Kagaku Ryoho 1986 0.75
73 [On the genetic homeostasis of somatic cells: molecular analysis with mutants in DNA metabolism]. Jpn J Genet 1988 0.75
74 Construction of an equalized cDNA library from human brain by semi-solid self-hybridization system. DNA Res 1994 0.75
75 Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript. DNA Res 1995 0.75
76 Thymidylate synthetase-positive and -negative murine mammary FM3A carcinoma cells as a useful system for detecting thymidylate synthetase inhibitors. FEBS Lett 1984 0.75
77 A restriction fragment length polymorphism (RFLP) locus of rat (Rattus norvegicus) linked to the Cs-1 locus of rat linkage group XIII. Biochem Genet 1992 0.75
78 [Genetic analyses of somatic cell mutants (author's transl)]. Tanpakushitsu Kakusan Koso 1982 0.75
79 [Cell life cycle and deoxyribonucleotide metabolism--molecular and genetic studies]. Tanpakushitsu Kakusan Koso 1984 0.75
80 Clustering of human chromosome fragments on the mouse genome by chromosome-mediated gene transfer. DNA Res 1998 0.75
81 [Regulation of cell-cycle dependent genes in mammalian cells]. Tanpakushitsu Kakusan Koso 1989 0.75
82 Identification of the UV-responsive sequence in the human tissue plasminogen activator gene. Biosci Biotechnol Biochem 2000 0.75
83 [Mapping of a senescent gene on human chromosome 7]. Tanpakushitsu Kakusan Koso 1996 0.75
84 [Structural analysis of mutant genes in mammalian somatic cells]. Tanpakushitsu Kakusan Koso 1982 0.75
85 A novel regulatory sequence affecting the constitutive expression of tissue plasminogen activator (tPA) gene in human melanoma (Bowes) cells. J Biol Chem 1994 0.75
86 [Cell death and genetic alterations induced by thymidylate stress]. Gan To Kagaku Ryoho 1984 0.75
87 Involvement of rBAT in Na(+)-dependent and -independent transport of the neurotransmitter candidate L-DOPA in Xenopus laevis oocytes injected with rabbit small intestinal epithelium poly A(+) RNA. Biochim Biophys Acta 2000 0.75
88 Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. Nucleic Acids Symp Ser 1985 0.75
89 Characterization of a human genomic DNA fragment which rescues defective lipid-linked oligosaccharide synthesis in a mutant G258 cell line isolated from the FM3A mouse mammary carcinoma cell line. Somat Cell Mol Genet 1998 0.75
90 [Chromosomal changes and genetic recombination]. Tanpakushitsu Kakusan Koso 1986 0.75
91 High level of aphidicolin resistance with multiple mutations in mouse FM3A cell mutants. Somat Cell Mol Genet 1990 0.75
92 [An approach to regulatory mechanisms of transcriptional termination in eukaryotic cells on reference to bacterial systems]. Tanpakushitsu Kakusan Koso 1985 0.75
93 Dephosphorylation of specific proteins during induction of senescence in immortal human fibroblasts expressing thermolabile SV40 T antigen. Biosci Biotechnol Biochem 1999 0.75