Published in Br Med Bull on April 01, 1985
In vivo labelling of intermediates in the discontinuous synthesis of mRNAs in Trypanosoma brucei. EMBO J (1987) 1.87
Characterization of the gene for the microbody (glycosomal) triosephosphate isomerase of Trypanosoma brucei. EMBO J (1986) 1.79
Topogenesis of microbody enzymes: a sequence comparison of the genes for the glycosomal (microbody) and cytosolic phosphoglycerate kinases of Trypanosoma brucei. EMBO J (1985) 1.63
Receptors for the host low density lipoproteins on the hemoflagellate Trypanosoma brucei: purification and involvement in the growth of the parasite. Proc Natl Acad Sci U S A (1988) 1.46
Maxicircle CR1 transcripts of Trypanosoma brucei are edited and developmentally regulated and encode a putative iron-sulfur protein homologous to an NADH dehydrogenase subunit. Mol Cell Biol (1992) 1.38
Common elements on the surface of glycolytic enzymes from Trypanosoma brucei may serve as topogenic signals for import into glycosomes. EMBO J (1987) 1.24
Extensive editing of CR2 maxicircle transcripts of Trypanosoma brucei predicts a protein with homology to a subunit of NADH dehydrogenase. Mol Cell Biol (1993) 1.03
Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem (2001) 1.00
Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity. Br J Pharmacol (2010) 0.98
Biogenesis of the glycosome in Trypanosoma brucei: the synthesis, translocation and turnover of glycosomal polypeptides. EMBO J (1987) 0.93
Stable introduction of exogenous DNA into Trypanosoma brucei. EMBO J (1987) 0.90
A cyclic nucleotide-independent protein kinase in Leishmania donovani. Biochem J (1986) 0.85
O2 consumption rates along the growth curve: new insights into Trypanosoma cruzi mitochondrial respiratory chain. J Bioenerg Biomembr (2011) 0.80
Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease. BMC Pharmacol Toxicol (2015) 0.77
A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes. Sci Rep (2016) 0.75
The Trypanosoma cruzi proteome. Science (2005) 2.63
Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett (1977) 2.44
Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei. J Cell Biol (1984) 1.82
Receptor-mediated endocytosis in the bloodstream form of Trypanosoma brucei. J Protozool (1987) 1.69
Topogenesis of microbody enzymes: a sequence comparison of the genes for the glycosomal (microbody) and cytosolic phosphoglycerate kinases of Trypanosoma brucei. EMBO J (1985) 1.63
Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J Biol Chem (1997) 1.59
Glycolytic enzymes of Trypanosoma brucei. Simultaneous purification, intraglycosomal concentrations and physical properties. Eur J Biochem (1986) 1.49
Receptors for the host low density lipoproteins on the hemoflagellate Trypanosoma brucei: purification and involvement in the growth of the parasite. Proc Natl Acad Sci U S A (1988) 1.46
Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei. Eur J Biochem (1984) 1.46
Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resist Updat (2001) 1.45
Two tandemly linked identical genes code for the glycosomal glyceraldehyde-phosphate dehydrogenase in Trypanosoma brucei. EMBO J (1986) 1.42
Retracted Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcriptional level. EMBO J (1991) 1.42
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. J Biol Chem (2001) 1.39
Perturbation of sterol biosynthesis by itraconazole and ketoconazole in Leishmania mexicana mexicana infected macrophages. Mol Biochem Parasitol (1989) 1.36
What controls glycolysis in bloodstream form Trypanosoma brucei? J Biol Chem (1999) 1.35
Subcellular fractionation of Trypanosoma brucei bloodstream forms with special reference to hydrolases. Eur J Biochem (1980) 1.25
Common elements on the surface of glycolytic enzymes from Trypanosoma brucei may serve as topogenic signals for import into glycosomes. EMBO J (1987) 1.24
Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania. Mol Biochem Parasitol (2000) 1.23
Kinetic properties of triose-phosphate isomerase from Trypanosoma brucei brucei. A comparison with the rabbit muscle and yeast enzymes. Eur J Biochem (1987) 1.22
Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme. Eur J Biochem (1989) 1.19
Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant. Eur J Biochem (1993) 1.19
The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase. Proteins (1991) 1.17
Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase. Proc Natl Acad Sci U S A (1998) 1.17
Trypanosoma brucei: an evaluation of salicylhydroxamic acid as a trypanocidal drug. Exp Parasitol (1976) 1.14
Localization of glycerol-3-phosphate oxidase in the mitochondrion and particulate NAD+-linked glycerol-3-phosphate dehydrogenase in the microbodies of the bloodstream form to Trypanosoma brucei. Eur J Biochem (1977) 1.14
The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species. Mol Biochem Parasitol (1984) 1.13
The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes. Proteins (1991) 1.12
Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A (1999) 1.12
Glycolysis in Trypanosoma brucei. Eur J Biochem (1980) 1.11
Regulation of glycolysis in Trypanosoma brucei: hexokinase and phosphofructokinase activity. Acta Trop (1982) 1.10
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem (1994) 1.10
The cytosolic and glycosomal isoenzymes of glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei have a distant evolutionary relationship. Eur J Biochem (1991) 1.09
Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei. Mol Biochem Parasitol (1988) 1.07
Glucose uptake by Trypanosoma brucei. Rate-limiting steps in glycolysis and regulation of the glycolytic flux. J Biol Chem (1991) 1.07
Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase. J Biol Chem (2000) 1.06
Particle-bound enzymes in the bloodstream form of Trypanosoma brucei. Eur J Biochem (1977) 1.05
Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6-bisphosphate and of glycolytic intermediates in Trypanosoma brucei. Eur J Biochem (1987) 1.05
Glycosomes may provide clues to the import of peroxisomal proteins. Trends Biochem Sci (1988) 1.05
A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured procyclic trypomastigotes. Mol Biochem Parasitol (1984) 1.04
Localization of malate dehydrogenase, adenylate kinase and glycolytic enzymes in glycosomes and the threonine pathway in the mitochondrion of cultured procyclic trypomastigotes of Trypanosoma brucei. Mol Biochem Parasitol (1981) 1.00
Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei. Proc Natl Acad Sci U S A (1999) 1.00
The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action. Acta Trop (1993) 0.99
Role of acidic compartments in Trypanosoma brucei, with special reference to low-density lipoprotein processing. Mol Biochem Parasitol (1993) 0.98
The potential use of inhibitors of glycerol-3-phosphate oxidase for chemotherapy of African trypanosomiasis. FEBS Lett (1976) 0.98
The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei. Biochem Soc Trans (2005) 0.98
Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase. Eur J Biochem (2000) 0.97
Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells. J Neurochem (1985) 0.97
The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme. Eur J Biochem (1997) 0.97
Myristate exchange. A second glycosyl phosphatidylinositol myristoylation reaction in African trypanosomes. J Biol Chem (1994) 0.96
New approach to screening drugs for activity against African trypanosomes. Nature (1977) 0.96
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Structure (2000) 0.96
Subcellular compartmentation of glycolytic intermediates in Trypanosoma brucei. Eur J Biochem (1981) 0.94
Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. Mol Biochem Parasitol (2000) 0.94
The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei. Kinetic properties and comparison with homologous enzymes. Eur J Biochem (1991) 0.94
Purification, localisation and characterisation of glucose-6-phosphate dehydrogenase of Trypanosoma brucei. Mol Biochem Parasitol (1999) 0.94
Biogenesis of the glycosome in Trypanosoma brucei: the synthesis, translocation and turnover of glycosomal polypeptides. EMBO J (1987) 0.93
Subcellular distribution of adenylate cyclase, cyclic-AMP phosphodiesterase, protein kinases and phosphoprotein phosphatase in Trypanosoma brucei. Mol Biochem Parasitol (1982) 0.93
Glyceraldehyde-phosphate dehydrogenase from Trypanosoma brucei. Comparison of the glycosomal and cytosolic isoenzymes. Eur J Biochem (1987) 0.93
Intracellular localization of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei. J Cell Sci (1989) 0.92
The phospholipases of Trypanosoma brucei bloodstream forms and cultured procyclics. Mol Biochem Parasitol (1982) 0.91
Localization of the initial steps in alkoxyphospholipid biosynthesis in glycosomes (microbodies) of Trypanosoma brucei. FEBS Lett (1984) 0.91
Glycerol kinase of Trypanosoma brucei. Cloning, molecular characterization and mutagenesis. Eur J Biochem (2000) 0.90
Molecular analysis of the cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana. Mol Biochem Parasitol (1992) 0.90
The phosphoglycerate kinases from Trypanosoma brucei. A comparison of the glycosomal and the cytosolic isoenzymes and their sensitivity towards suramin. Eur J Biochem (1987) 0.89
Triose-phosphate isomerase of Leishmania mexicana mexicana. Cloning and characterization of the gene, overexpression in Escherichia coli and analysis of the protein. Eur J Biochem (1994) 0.89
Preliminary crystallographic studies of triosephosphate isomerase from the blood parasite Trypanosoma brucei brucei. J Mol Biol (1984) 0.89
Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: an evolutionary scenario of subcellular compartmentation in kinetoplastida. J Mol Evol (1995) 0.89
Chemostat cultures of Leishmania donovani promastigotes and Trypanosoma brucei procyclic trypomastigotes. Mol Biochem Parasitol (1991) 0.89
The evolutionary origin of glycosomes. Parasitol Today (1991) 0.89
The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem J (1995) 0.89
Aerobic and anaerobic glucose metabolism of Phytomonas sp. isolated from Euphorbia characias. Mol Biochem Parasitol (1994) 0.88
Stimulation of Trypanosoma brucei pyruvate kinase by fructose 2,6-bisphosphate. Eur J Biochem (1985) 0.88
Subcellular localisation of dihydrolipoamide dehydrogenase and detection of lipoic acid in bloodstream forms of Trypanosoma brucei. Eur J Biochem (1990) 0.88
Oligomycin sensitivity of the mitochondrial ATPase as a marker for fly transmissability and the presence of functional kinetoplast DNA in African trypanosomes. Comp Biochem Physiol B (1976) 0.88
Characterization of carbohydrate metabolism and demonstration of glycosomes in a Phytomonas sp. isolated from Euphorbia characias. Mol Biochem Parasitol (1992) 0.87
Uptake and turnover of glucose in Leishmania donovani. Mol Biochem Parasitol (1993) 0.87
Pyruvate kinase of Leishmania mexicana mexicana. Cloning and analysis of the gene, overexpression in Escherichia coli and characterization of the enzyme. Mol Biochem Parasitol (1994) 0.87
Mutual adjustment of glucose uptake and metabolism in Trypanosoma brucei grown in a chemostat. J Bacteriol (1992) 0.87
Comparative physiology of two protozoan parasites, Leishmania donovani and Trypanosoma brucei, grown in chemostats. J Bacteriol (1992) 0.86
Molecular characterisation of Trypanosoma brucei alkyl dihydroxyacetone-phosphate synthase. Mol Biochem Parasitol (1999) 0.86
Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation. Protein Sci (1992) 0.86
A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata. Mol Biochem Parasitol (1992) 0.86
A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and Leishmania. FEBS Lett (1981) 0.85
Characterization of pyruvate kinase of Trypanosoma brucei and its role in the regulation of carbohydrate metabolism. Mol Biochem Parasitol (1991) 0.85
Cloning and characterization of Leishmania mexicana fructose-1,6-bisphosphate aldolase. Mol Biochem Parasitol (1999) 0.85
Cloning and analysis of the PTS-1 receptor in Trypanosoma brucei. Mol Biochem Parasitol (1999) 0.85
Synthesis and activity of inhibitors highly specific for the glycolytic enzymes from Trypanosoma brucei. Mol Biochem Parasitol (1993) 0.85
A chemostat study on proline uptake and metabolism of Leishmania donovani. J Protozool (1992) 0.85
Trypanosoma brucei brucei: antigenic stability of its LDL receptor and immunological cross-reactivity with the LDL receptor of the mammalian host. Exp Parasitol (1992) 0.84
The dihydroxyacetonephosphate pathway for biosynthesis of ether lipids in Leishmania mexicana promastigotes. Mol Biochem Parasitol (1997) 0.84
An M(r) 145,000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order. Mol Biochem Parasitol (1997) 0.83
Pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei is mediated by a facilitated diffusion carrier. Biochem Biophys Res Commun (1992) 0.83
Alkyl dihydroxyacetone phosphate synthase in glycosomes of Trypanosoma brucei. Biochim Biophys Acta (1995) 0.82
Identification of 2-enoyl coenzyme A hydratase and NADP(+)-dependent 3-hydroxyacyl-CoA dehydrogenase activity in glycosomes of procyclic Trypanosoma brucei. Mol Biochem Parasitol (1996) 0.82
Cloning and characterization of the NAD-linked glycerol-3-phosphate dehydrogenases of Trypanosoma brucei brucei and Leishmania mexicana mexicana and expression of the trypanosome enzyme in Escherichia coli. Mol Biochem Parasitol (1997) 0.82
Macrophage activation by polymeric nanoparticles of polyalkylcyanoacrylates: activity against intracellular Leishmania donovani associated with hydrogen peroxide production. Pharm Res (1992) 0.82
Localisation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the mitochondrial matrix of Trypanosoma brucei procyclics. Z Naturforsch C (2000) 0.82
Localization of 3'-nucleotidase and calcium-dependent endoribonuclease in the plasma-membrane of Trypanosoma brucei. Acta Trop (1986) 0.82
Subcellular distribution and characterization of glucosephosphate isomerase in Leishmania mexicana mexicana. Mol Biochem Parasitol (1994) 0.82
Drug targeting with polyalkylcyanoacrylate nanoparticles: in vitro activity of primaquine-loaded nanoparticles against intracellular Leishmania donovani. Ann Trop Med Parasitol (1992) 0.81