PubRank

P A Furman

Author PubWeight™ 99.70‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci U S A 1977 11.20
2 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A 1985 10.71
3 Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci U S A 1986 8.48
4 Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine. J Biol Chem 1978 5.43
5 Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. J Virol 1979 4.53
6 Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother 1992 3.52
7 3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob Agents Chemother 1987 2.60
8 Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science 1987 2.51
9 Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function. J Biol Chem 1981 2.29
10 Metabolism of acyclovir in virus-infected and uninfected cells. Antimicrob Agents Chemother 1981 2.21
11 Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. Virology 1980 2.18
12 Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. J Virol 2001 1.98
13 Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities. Biochem Pharmacol 1981 1.92
14 Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine. Proc Natl Acad Sci U S A 1993 1.84
15 Acyclovir triphosphate is a suicide inactivator of the herpes simplex virus DNA polymerase. J Biol Chem 1984 1.83
16 Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine. J Virol 1982 1.79
17 Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities. J Virol 1981 1.74
18 Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U. Antimicrob Agents Chemother 1984 1.67
19 Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin. Nucleic Acids Res 1983 1.56
20 Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1. Am J Med 1982 1.49
21 Phosphorylation of acyclovir [9-(2-hydroxyethoxymethyl)guanine] in Epstein-Barr virus-infected lymphoblastoid cell lines. J Virol 1981 1.44
22 Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir. Antimicrob Agents Chemother 1980 1.41
23 Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells. Biochem Biophys Res Commun 1988 1.30
24 2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir. Proc Natl Acad Sci U S A 1989 1.26
25 Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase involves improved nucleotide selection. Proc Natl Acad Sci U S A 1985 1.21
26 Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates. Antimicrob Agents Chemother 1985 1.17
27 Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir. Antimicrob Agents Chemother 1984 1.13
28 Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. Antimicrob Agents Chemother 1987 1.13
29 Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate. J Biol Chem 1996 1.12
30 Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model. Antimicrob Agents Chemother 1994 1.08
31 Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition. Proc Natl Acad Sci U S A 1985 1.08
32 RNA-dependent DNA polymerase activity in preparations of a mutant of Newcastle disease virus arising from persistently infected L cells. J Virol 1973 1.04
33 The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 1993 0.99
34 Crosslinking of substrates occurs exclusively to the p66 subunit of heterodimeric HIV-1 reverse transcriptase. Biochem Biophys Res Commun 1991 0.98
35 Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1. Am J Med 1982 0.96
36 Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus-infected cells. Am J Med 1982 0.94
37 Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus. Antimicrob Agents Chemother 1993 0.92
38 Initial binding of 2'-deoxynucleoside 5'-triphosphates to human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem 1991 0.92
39 Viral resistance, clinical experience. Scand J Infect Dis Suppl 1985 0.91
40 Biochemical analysis of human immunodeficiency virus-1 reverse transcriptase containing a mutation at position lysine 263. J Biol Chem 1993 0.90
41 Effect of acyclovir on viral protein synthesis in cells infected with herpes simplex virus type 1. Antimicrob Agents Chemother 1983 0.88
42 Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding. Proc Natl Acad Sci U S A 1993 0.88
43 Identification of the nucleotide binding site of HIV-1 reverse transcriptase using dTTP as a photoaffinity label. Biochemistry 1993 0.83
44 Ribonucleotide reductase of herpes simplex virus type 2 resembles that of herpes simplex virus type 1. J Virol 1984 0.81
45 Recombinant human immunodeficiency virus type 1 reverse transcriptase is heterogeneous. J Acquir Immune Defic Syndr Hum Retrovirol 1996 0.81
46 The selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Reproduced from Proc. Natl. Acad. Sci. USA 74, 5716-5720 (1977) Rev Med Virol 1999 0.79
47 Investigation of the stereochemical course of DNA synthesis catalysed by human immunodeficiency virus type 1 reverse transcriptase. Biochem Biophys Res Commun 1989 0.78
48 Conformation and local environment of nucleotides bound to HIV type 1 reverse transcriptase (HIV-1 RT) in the ground state. Nucleosides Nucleotides Nucleic Acids 2000 0.77
49 Purification and kinetic characterization of equine infectious anemia virus reverse transcriptase. Biochem Biophys Res Commun 1991 0.76
50 Chemotherapy of herpesvirus infections. Curr Eye Res 1987 0.75
51 Screening for potential toxicity of antiviral therapies. Curr Opin Drug Discov Devel 2000 0.75
52 The biosynthesis of deoxyguanosine triphosphate in herpes simplex type-1 infected Vero cells treated with acyclovir and hydroxyurea. Adv Exp Med Biol 1986 0.75
53 Inhibition by acyclovir of herpes simplex virus type 2 morphologically transformed cell growth in tissue culture and tumor-bearing animals. J Med Virol 1983 0.75