Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMID 3047037)

Published in Hepatology on October 27, 1988

Authors

W C Duane1, D B Hunninghake, M L Freeman, P A Pooler, L A Schlasner, R L Gebhard

Author Affiliations

1: Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417.

Articles citing this

Non-cardiovascular effects associated with statins. BMJ (2014) 1.24

Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia. Gut (1990) 0.94

Targets for current pharmacologic therapy in cholesterol gallstone disease. Gastroenterol Clin North Am (2010) 0.90

Therapy of gallstone disease: What it was, what it is, what it will be. World J Gastrointest Pharmacol Ther (2012) 0.90

Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol. Eur J Clin Invest (2013) 0.85

Statin use and the risk of cholecystectomy in women. Gastroenterology (2009) 0.84

Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. J Lipid Res (2012) 0.84

Lovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogs. Dig Dis Sci (2002) 0.82

A novel therapeutic effect of statins on nephrogenic diabetes insipidus. J Cell Mol Med (2015) 0.81

Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation: epidemiological study in an unselected population. Dig Dis Sci (2001) 0.81

Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects. J Clin Invest (1993) 0.80

Effects of simvastatin and cholestyramine on bile lipid composition and gall bladder motility in patients with hypercholesterolaemia. Gut (1995) 0.79

Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat. J Clin Invest (1989) 0.79

Cholelithiasic disease and associated factors in a Spanish population. Dig Dis Sci (2001) 0.77

Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog. Ann Surg (1991) 0.77

Statins and their role in acute pancreatitis: Case report and literature review. World J Gastrointest Pharmacol Ther (2014) 0.75

Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels. Lipids Health Dis (2016) 0.75

Effect of long term simvastatin administration as an adjunct to ursodeoxycholic acid: evidence for a synergistic effect on biliary bile acid composition but not on serum lipids in humans. Gut (1999) 0.75

Articles by these authors

(truncated to the top 100)

Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA (2001) 13.65

Recruitment for controlled clinical trials: literature summary and annotated bibliography. Control Clin Trials (1997) 5.67

Recruitment experience in clinical trials: literature summary and annotated bibliography. Control Clin Trials (1987) 3.39

Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis. Lancet (1983) 3.24

Clostridium difficile-associated diarrhea and colitis in adults. A prospective case-controlled epidemiologic study. Arch Intern Med (1986) 3.06

Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. PREVENT Investigators. Circulation (2000) 2.96

Objective evaluation of endoscopy skills during training. Ann Intern Med (1993) 2.92

Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Circulation (1994) 2.84

Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Cancer Inst (1998) 2.21

Biliary cannulation during endoscopic retrograde cholangiopancreatography: core technique and recent innovations. Endoscopy (2009) 2.17

Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators. Circulation (2000) 2.07

Sclerotherapy for actively bleeding esophageal varices in male alcoholics with cirrhosis. Veterans Affairs Cooperative Variceal Sclerotherapy Group. Gastrointest Endosc (1997) 2.05

Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial. JAMA (2000) 2.02

The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day. Am J Cardiol (1997) 1.98

Effects of thiazide diuretics on plasma lipids and lipoproteins in mildly hypertensive patients: a double-blind controlled trial. Ann Intern Med (1981) 1.89

Endoscopic intervention for biliary leaks after laparoscopic cholecystectomy: a multicenter review. Gastrointest Endosc (1998) 1.85

An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture. J Clin Invest (1974) 1.74

Clinical and economic outcomes of individuals with severe peptic ulcer hemorrhage and nonbleeding visible vessel: an analysis of two prospective clinical trials. Am J Gastroenterol (1998) 1.66

Clinical implications of postsurgical adhesions. Hum Reprod Update (2001) 1.66

Endoscopic ultrasound rendezvous for bile duct access using a transduodenal approach: cumulative experience at a single center. A case series. Endoscopy (2010) 1.52

Effect of an aggressive lipid-lowering strategy on progression of atherosclerosis in the left main coronary artery from patients in the post coronary artery bypass graft trial. Circulation (2001) 1.46

Factors influencing the development of hypercholesterolemia after cardiac transplantation. Am J Cardiol (1992) 1.39

HL-A antigen type and small-intestinal disease in dermatitis herpetiformis. Lancet (1973) 1.34

Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers. Science (1986) 1.28

Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group. Clin Cardiol (2000) 1.27

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines. Oncogene (2010) 1.26

Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase. Biochem Biophys Res Commun (2000) 1.22

Increased leucocyte oxidative metabolism in hyperlipoproteinaemia. Lancet (1982) 1.20

Multi-faceted regulation of gamma-glutamylcysteine synthetase. J Cell Physiol (2000) 1.18

Effects of a vigorous walking program on body composition, and carbohydrate and lipid metabolism of obese young men. Am J Clin Nutr (1979) 1.13

Conjugation of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 with intracellular glutathione and enhancement of its antiproliferative activity by glutathione depletion. Cancer Res (1990) 1.13

Long-term effects of clofibrate (Atromid-S) on serum lipids in man. Circulation (1969) 1.11

Major hemorrhage from endoscopic sphincterotomy: risk factor analysis. J Clin Gastroenterol (1994) 1.10

Cholesterol lowering in the elderly. Results of the Cholesterol Reduction in Seniors Program (CRISP) pilot study. Arch Intern Med (1994) 1.10

Cholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemia. Am J Clin Nutr (1990) 1.09

The Minnesota Regional Peripheral Arterial Disease Screening Program: toward a definition of community standards of care. Vasc Med (2001) 1.09

Lipids and hypertension. Implications of new guidelines for cholesterol management in the treatment of hypertension. Am J Med (1986) 1.08

Therapeutic pancreatic endoscopy after Whipple resection requires rendezvous access. Endoscopy (2009) 1.07

Toward improving outcomes of ERCP. Gastrointest Endosc (1998) 1.06

Cryptosporidial carriage without symptoms in the acquired immunodeficiency syndrome (AIDS) Ann Intern Med (1990) 1.04

Effect of the novel antiplatelet agent cilostazol on plasma lipoproteins in patients with intermittent claudication. Arterioscler Thromb Vasc Biol (1998) 1.04

Accurate diagnosis of pancreas divisum by linear-array endoscopic ultrasonography. Endoscopy (2004) 1.03

Effect of estrogen plus progestin on risk for biliary tract surgery in postmenopausal women with coronary artery disease. The Heart and Estrogen/progestin Replacement Study. Ann Intern Med (2001) 1.03

Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent. Biochem Biophys Res Commun (1997) 1.02

Relief of pain of Fabry's disease by diphenylhydantoin. Neurology (1973) 1.02

Endoscopic ultrasound-guided bile duct access for rendezvous ERCP drainage in the setting of intradiverticular papilla. Endoscopy (2005) 1.01

An economic analysis of patients with active arterial peptic ulcer hemorrhage treated with endoscopic heater probe, injection sclerosis, or surgery in a prospective, randomized trial. Gastrointest Endosc (1997) 1.01

Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response. J Cell Physiol (1997) 1.01

27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 4. Efficacy of risk factor management. J Am Coll Cardiol (1996) 1.00

Biliary-shunt fistula following transjugular intrahepatic portosystemic shunt placement. Gastroenterology (1996) 1.00

Gallbladder emptying stimuli in obese and normal-weight subjects. Hepatology (1992) 0.99

Prescription writing by generic name and drug cost. J Chronic Dis (1967) 0.96

Lovastatin treatment inhibits sterol synthesis and induces HMG-CoA reductase activity in mononuclear leukocytes of normal subjects. J Lipid Res (1989) 0.96

Drug interactions with warfarin. Arch Intern Med (1968) 0.95

Strategies in the treatment of diffuse pontine gliomas: the therapeutic role of hyperfractionated radiotherapy and chemotherapy. J Neurooncol (1996) 0.94

Recruitment in NHLBI population-based studies and randomized clinical trials: data analysis and survey results. Control Clin Trials (1987) 0.94

The effect of severe zinc deficiency on activity of intestinal disaccharidases and 3-hydroxy-3-methylglutaryl coenzyme A reductase in the rat. J Nutr (1983) 0.94

Proposed thresholds for pancreatic tissue volume for safe intraportal islet autotransplantation after total pancreatectomy. Am J Transplant (2013) 0.94

Radiopotentiation by the oral platinum agent, JM216: role of repair inhibition. Int J Radiat Oncol Biol Phys (1999) 0.94

Are you safe for your patients - how many ERCPs should you be doing? Endoscopy (2008) 0.94

Abnormal intestinal permeability to sugars in diabetes mellitus. Diabetologia (1986) 0.94

Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux. Biochem Biophys Res Commun (1998) 0.93

Thallium scintigraphy during dobutamine infusion: nonexercise-dependent screening test for coronary disease. Am Heart J (1984) 0.93

Lovastatin (mevinolin) in the treatment of heterozygous familial hypercholesterolemia. A multicenter study. Ann Intern Med (1987) 0.92

Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft Trial. Diabetes (1999) 0.92

Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C. Biochemistry (1997) 0.91

Significant clinical implications of prophylactic pancreatic stent placement in previously normal pancreatic ducts. Endoscopy (2009) 0.91

A randomized, controlled trial of transcutaneous carbon dioxide monitoring during ERCP. Gastrointest Endosc (2000) 0.91

Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate. Radiat Res (1997) 0.91

Patient perceptions about the influence of cholesterol on heart disease. Am J Prev Med (1992) 0.91

Effect of pharmacologic lipid lowering on health-related quality of life in older persons: results from the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study. J Am Geriatr Soc (1997) 0.91

A unique case of breast carcinoma producing pancreatic-type isoamylase. Gastroenterology (1988) 0.90

Shingles esophagitis: endoscopic diagnosis in two patients. Gastrointest Endosc (1984) 0.90

Treatment of type III hyperlipoproteinemia with four different treatment regimens. Atherosclerosis (1984) 0.90

Blood lipids and lipoproteins in a Minnesota urban population. J Chronic Dis (1980) 0.90

Beta-hexosaminidases in the nervous system: the quantitative histochemistry of beta-glucosaminidase and beta-galactosaminidase in the cerebellar cortex and subjacent white matter. J Histochem Cytochem (1970) 0.90

Aggressive cholesterol lowering delays saphenous vein graft atherosclerosis in women, the elderly, and patients with associated risk factors. NHLBI post coronary artery bypass graft clinical trial. Post CABG Trial Investigators. Circulation (1999) 0.90

Silicone-covered Wallstent prototypes for palliation of malignant esophageal obstruction and digestive-respiratory fistulas. Gastrointest Endosc (1997) 0.89

Visualization of metastatic liver disease on technetium-99m bone scintigraphy. Clin Nucl Med (1987) 0.89

Gamma irradiation increases hsp-70 in Chinese hamster ovary cells. Radiat Res (1993) 0.89

Effect of exorphins on gastrointestinal function, hormonal release, and appetite. Gastroenterology (1983) 0.89

Psyllium-enriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol, in hypercholesterolemic adults: results of a meta-analysis. J Nutr (1997) 0.89

Sensitivity of the canine pancreatic intraductal pressure to subclinical reduction in cholinesterase acitivity. Ann Surg (1979) 0.89

The effect of pH on hyperthermic and x ray induced cell killing. Int J Radiat Oncol Biol Phys (1981) 0.88

Cholesterol-lowering effects of psyllium hydrophilic mucilloid. Adjunct therapy to a prudent diet for patients with mild to moderate hypercholesterolemia. JAMA (1989) 0.88

Effect of cholestyramine and colestipol on the absorption of phenytoin. Eur J Clin Pharmacol (1983) 0.87

The effect of butoxamine on catecholamine-induced metabolic changes in humans. Clin Pharmacol Ther (1966) 0.87

Assignment of the gene (GLCLC) that encodes the heavy subunit of gamma-glutamylcysteine synthetase to human chromosome 6. Cytogenet Cell Genet (1995) 0.87

Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells. Arch Biochem Biophys (1991) 0.87

Clofibrate effect on catecholamine-induced metabolic changes in humans. Metabolism (1968) 0.86

Clinical and endoscopic findings in patients early in the course of clostridium difficile-associated pseudomembranous colitis. Am J Med (1985) 0.86

Dermatitis herpetiformis. Immunologic concomitants of small intestinal disease and relationship to histocompatibility antigen HL-A8. J Clin Invest (1974) 0.86

30 years of ERCP and still the same problems? Endoscopy (2007) 0.86

Assignment of the human gene (GLCLR) that encodes the regulatory subunit of gamma-glutamylcysteine synthetase to chromosome 1p21. Cytogenet Cell Genet (1996) 0.85

The Eating Pattern Assessment Tool: a simple instrument for assessing dietary fat and cholesterol intake. J Am Diet Assoc (1994) 0.85

Effects of fluvastatin (XU 62-320), an HMG-CoA reductase inhibitor, on the distribution and composition of low density lipoprotein subspecies in humans. Atherosclerosis (1991) 0.84

Carbohydrates in normal urine and blood serum as determined by high-resolution column chromatography. Am J Clin Pathol (1970) 0.84

In vitro studies of ulcerative ileojejunitis. Gastroenterology (1975) 0.84

Physiological markers of smoking and their relation to coronary heart disease. The Lipid Research Clinics Coronary Primary Prevention Trial. Arteriosclerosis (1987) 0.84

Acute viral enteritis and exacerbations of inflammatory bowel disease. Gastroenterology (1982) 0.83