Published in Development on January 01, 1988
Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet (1995) 4.46
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A (1997) 2.91
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J (1996) 2.26
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev (1997) 2.25
p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. Am J Hum Genet (2001) 2.02
Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development (2012) 2.01
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development (2008) 1.74
Splitting p63. Am J Hum Genet (2002) 1.62
Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn (2006) 1.61
Regional regulation of palatal growth and patterning along the anterior-posterior axis in mice. J Anat (2005) 1.60
Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A (1999) 1.54
Face facts: genes, environment, and clefts. Am J Hum Genet (1995) 1.52
A dosage-dependent role for Spry2 in growth and patterning during palate development. Mech Dev (2007) 1.51
Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol (2006) 1.50
Prdm16 is required for normal palatogenesis in mice. Hum Mol Genet (2009) 1.46
TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell (2001) 1.42
Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. Mol Cell Biol (2001) 1.38
Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development (2009) 1.37
Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn (2006) 1.37
Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol (2010) 1.34
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest (2006) 1.32
Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol (2009) 1.28
The gene for Treacher Collins syndrome maps to the long arm of chromosome 5. Am J Hum Genet (1991) 1.19
Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. Am J Pathol (2011) 1.16
The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice. Development (2008) 1.16
Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate. Proc Natl Acad Sci U S A (2010) 1.15
A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis (2007) 1.13
Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression. Dev Biol (2010) 1.12
Palatal seam disintegration: to die or not to die? that is no longer the question. Dev Dyn (2008) 1.12
Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant. Pathogenetics (2009) 1.08
Narrowing the position of the Treacher Collins syndrome locus to a small interval between three new microsatellite markers at 5q32-33.1. Am J Hum Genet (1993) 1.07
Molecular pathology of the fibroblast growth factor family. Hum Mutat (2009) 1.06
Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants. Dev Biol (2007) 1.06
Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol (2010) 1.06
Examination of a palatogenic gene program in zebrafish. Dev Dyn (2011) 1.06
The mechanism of TGF-β signaling during palate development. Oral Dis (2011) 1.04
Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development (2009) 1.02
Mice with an anterior cleft of the palate survive neonatal lethality. Dev Dyn (2008) 0.95
Histomorphological study of palatal shelf elevation during murine secondary palate formation. Dev Dyn (2011) 0.94
Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet (2012) 0.93
Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development (2013) 0.92
Mechanisms of palatal epithelial seam disintegration by transforming growth factor (TGF) beta3. Dev Biol (2007) 0.91
Mechanisms of transforming growth factor β induced cell cycle arrest in palate development. J Cell Physiol (2011) 0.91
Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem (2013) 0.90
Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis. J Biol Chem (2013) 0.90
Cleft lip and palate genetics and application in early embryological development. Indian J Plast Surg (2009) 0.88
The gene responsible for X-linked cleft palate (CPX) in a British Columbia native kindred is localized between PGK1 and DXYS1. Am J Hum Genet (1992) 0.87
Nicotine inhibits palatal fusion and modulates nicotinic receptors and the PI-3 kinase pathway in medial edge epithelia. Orthod Craniofac Res (2003) 0.87
Induction of palate epithelial mesenchymal transition by transforming growth factor β3 signaling. Dev Growth Differ (2012) 0.87
Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res (2008) 0.87
Gsk3β is required in the epithelium for palatal elevation in mice. Dev Dyn (2010) 0.87
Molecular signaling along the anterior-posterior axis of early palate development. Front Physiol (2013) 0.86
Roles of BMP signaling pathway in lip and palate development. Front Oral Biol (2012) 0.86
Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development. Dev Biol (2014) 0.86
Synaptic inhibition and γ-aminobutyric acid in the mammalian central nervous system. Proc Jpn Acad Ser B Phys Biol Sci (2013) 0.85
Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn (2010) 0.85
Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol (2015) 0.84
Alteration of medial-edge epithelium cell adhesion in two Tgf-beta3 null mouse strains. Differentiation (2008) 0.84
miR-200b regulates cell migration via Zeb family during mouse palate development. Histochem Cell Biol (2012) 0.83
Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development. Dev Biol (2011) 0.83
A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development. PLoS One (2010) 0.83
Tgf-beta-mediated FasL-Fas-Caspase pathway is crucial during palatogenesis. J Dent Res (2011) 0.83
Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate. Cleft Palate Craniofac J (2010) 0.83
Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis. Front Physiol (2012) 0.83
Signaling networks in palate development. Wiley Interdiscip Rev Syst Biol Med (2014) 0.83
Temporal and spatial expression of Hoxa-2 during murine palatogenesis. Cell Mol Neurobiol (2000) 0.82
Genetics of cleft lip and palate : a review. Malays J Med Sci (2007) 0.82
The etiology of cleft palate formation in BMP7-deficient mice. PLoS One (2013) 0.82
MiR-200b is involved in Tgf-β signaling to regulate mammalian palate development. Histochem Cell Biol (2011) 0.82
A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. PLoS Genet (2016) 0.82
Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations. Mol Genet Genomic Med (2013) 0.82
Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development. Indian J Hum Genet (2012) 0.81
Characterization of chromosomal inversion of the mouse hairy ears (Eh) mutation associated with cleft palate. Mamm Genome (2007) 0.81
Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo. PLoS One (2012) 0.81
Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn (2012) 0.80
Divergent palate morphology in turtles and birds correlates with differences in proliferation and BMP2 expression during embryonic development. J Exp Zool B Mol Dev Evol (2013) 0.80
Evidence for transforming growth factor-beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from Indian sub-continent. Med Oral Patol Oral Cir Bucal (2012) 0.80
Intra-amniotic transient transduction of the periderm with a viral vector encoding TGFβ3 prevents cleft palate in Tgfβ3(-/-) mouse embryos. Mol Ther (2012) 0.80
Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn (2014) 0.80
Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development (2015) 0.79
Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn (2014) 0.79
Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One (2013) 0.79
Spatiotemporal localization of periostin and its potential role in epithelial-mesenchymal transition during palatal fusion. Cells Tissues Organs (2010) 0.79
IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion. Sci Rep (2015) 0.78
Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate. PLoS Genet (2016) 0.78
Cellular activity in the developing palate of the rat assessed by the staining of nucleolar organiser regions. J Anat (1993) 0.78
Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum Genet (2014) 0.78
Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation. Dev Dyn (2015) 0.78
Overexpression of mouse TTF-2 gene causes cleft palate. J Cell Mol Med (2012) 0.78
The clinical features of spondyloepiphyseal dysplasia congenita resulting from the substitution of glycine 997 by serine in the alpha 1(II) chain of type II collagen. J Med Genet (1993) 0.78
Analysis of Snail1 function and regulation by Twist1 in palatal fusion. Front Physiol (2013) 0.78
Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Development (2016) 0.78
Further evidence suggesting a role for variation in ARHGAP29 variants in nonsyndromic cleft lip/palate. Birth Defects Res A Clin Mol Teratol (2014) 0.77
Control elements targeting Tgfb3 expression to the palatal epithelium are located intergenically and in introns of the upstream Ift43 gene. Front Physiol (2014) 0.77
Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet (2015) 0.77
The expression of TGF-β3 for epithelial-mesenchyme transdifferentiated MEE in palatogenesis. J Mol Histol (2010) 0.77
Molecular and Cellular Mechanisms of Palate Development. J Dent Res (2017) 0.77
Implications of TGFβ on Transcriptome and Cellular Biofunctions of Palatal Mesenchyme. Front Physiol (2012) 0.76