Published in Ann Intern Med on May 01, 1988
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Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest (1990) 3.74
Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol (1988) 3.54
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest (1994) 3.49
Teenagers' health concerns: implications for primary health care professionals. J R Coll Gen Pract (1989) 3.00
Use of a questionnaire in general practice to increase the recognition of patients with excessive alcohol consumption. Br Med J (Clin Res Ed) (1985) 2.85
Chronic fatigue in general practice: is counselling as good as cognitive behaviour therapy? A UK randomised trial. Br J Gen Pract (2001) 2.76
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What are safe levels of alcohol consumption? Br Med J (Clin Res Ed) (1984) 2.54
L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse. Br J Pharmacol (1991) 2.53
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An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation. Am J Hum Genet (2006) 2.23
Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes (1992) 2.16
A pilot study of sexual lifestyle in a random sample of the population of Great Britain. AIDS (1989) 2.13
Safe limits of drinking: general practitioners' views. Br Med J (Clin Res Ed) (1985) 2.06
7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol (1993) 1.97
beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol (1994) 1.97
Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care (1992) 1.92
In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest (1986) 1.87
Evaluation of the feasibility, reliability and diagnostic value of shortened versions of the geriatric depression scale. Br J Gen Pract (1995) 1.86
The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab (1997) 1.82
Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest (1998) 1.82
Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake. Am J Physiol (1994) 1.74
Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J Clin Invest (1995) 1.71
Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats. Am J Physiol (1995) 1.68
Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol (1993) 1.66
Down your drink: a web-based intervention for people with excessive alcohol consumption. Alcohol Alcohol (2003) 1.62
Virtual outreach: economic evaluation of joint teleconsultations for patients referred by their general practitioner for a specialist opinion. BMJ (2003) 1.62
Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults. Am J Physiol (1991) 1.50
Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting. Am J Psychiatry (1996) 1.45
Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells. J Clin Invest (1986) 1.43
Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus. Diabetes (1986) 1.41
Coping with patients' problem drinking. Practitioner (1989) 1.39
Blood pressure, smoking, obesity and alcohol consumption in black and white patients in general practice. J Hum Hypertens (1987) 1.38
Embedding guidelines into direct physician order entry: simple methods, powerful results. Proc AMIA Symp (1999) 1.37
Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake. J Clin Invest (1990) 1.36
An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus. Br J Pharmacol (1992) 1.33
Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol (1993) 1.32
Performance of different mono- and multiplex nucleic acid amplification tests on a multipathogen external quality assessment panel. J Clin Microbiol (2011) 1.27
Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families. J Med Genet (1985) 1.25
Linking up with the over 75s. Br J Gen Pract (1990) 1.25
Patients with alcohol problems--simple questioning is the key to effective identification and management. Br J Gen Pract (2001) 1.24
Chronic fatigue in general practice: economic evaluation of counselling versus cognitive behaviour therapy. Br J Gen Pract (2001) 1.21
Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J Clin Endocrinol Metab (1991) 1.19
Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab (1990) 1.18
Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity. J Clin Endocrinol Metab (1990) 1.18
Capacitative Ca2+ entry and the regulation of smooth muscle tone. Trends Pharmacol Sci (1998) 1.18
Cardiovascular effects of urotensin II in anesthetized and pithed rats. Gen Comp Endocrinol (1986) 1.17
Long term survival after intensive care. BMJ (1990) 1.17
Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. J Clin Invest (1991) 1.16
Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy. J Clin Invest (1991) 1.16
Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse. Br J Pharmacol (1992) 1.14
An exploratory study of language interpretation services provided by videoconferencing. J Telemed Telecare (2003) 1.10
The effect of drugs on various parameters of mouse behaviour in a modified head-dipping test [proceedings]. Br J Pharmacol (1976) 1.09
Use of a variable tracer infusion method to determine glucose turnover in humans. Am J Physiol (1990) 1.08
The future role of telemedicine at the interface between primary and secondary care. J Telemed Telecare (1996) 1.05
Multicentre quality control study for detection of Mycobacterium tuberculosis in clinical samples by nucleic amplification methods. Clin Microbiol Infect (2004) 1.02
Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes (1987) 1.01
Linking education, research, and service in general practice. BMJ (1998) 1.00
A multi-centre pilot proficiency programme to assess the quality of molecular detection of respiratory viruses. J Clin Virol (2005) 0.97
Kinetics of insulin-mediated and non-insulin-mediated glucose uptake in humans. Diabetes (1990) 0.96
Effects of aging on glucose-mediated glucose disposal and glucose transport. J Clin Invest (1986) 0.96
The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol (1995) 0.95
Health checks for people aged 75 and over. Occas Pap R Coll Gen Pract (1993) 0.95
Intensive conventional insulin therapy for type II diabetes. Metabolic effects during a 6-mo outpatient trial. Diabetes Care (1993) 0.95
Expression of mRNAs encoding uncoupling proteins in human skeletal muscle: effects of obesity and diabetes. Diabetes (1998) 0.94
Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. Diabetes (1994) 0.94
Correlation between store-operated cation current and capacitative Ca2+ influx in smooth muscle cells from mouse anococcygeus. Eur J Pharmacol (1999) 0.93
Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT 4 in skeletal muscles. J Clin Endocrinol Metab (1995) 0.93
Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow. Am J Physiol (1992) 0.92
Secretion and hepatic extraction of insulin after weight loss in obese noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1988) 0.91
Evaluation of splenectomy in large granular lymphocyte leukaemia. Br J Haematol (1987) 0.91
Skeletal muscle proteolysis is reduced in noninsulin-dependent diabetes mellitus and is unaltered by euglycemic hyperinsulinemia or intensive insulin therapy. J Clin Endocrinol Metab (1995) 0.90
Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity. Diabetes (1990) 0.89
A study of 9-nitrocamptothecin (RFS-2000) in patients with advanced pancreatic cancer. Int J Oncol (1999) 0.89
The eye lens cytoskeleton. Eye (Lond) (1999) 0.88
Individual discrimination of humans by odor. Physiol Behav (1977) 0.88
Up-regulation of novel intermediate filament proteins in primary fiber cells: an indicator of all vertebrate lens fiber differentiation? Anat Rec (2000) 0.88
Effects of aging on insulin secretion. Diabetes (1989) 0.87
Lipid metabolism in non-insulin-dependent diabetes: effects of long-term treatment with fructose-supplemented mixed meals. Am J Clin Nutr (1989) 0.87
Safe limits of drinking: patients' views. Br Med J (Clin Res Ed) (1988) 0.86
Evidence that glucose transport is rate-limiting for in vivo glucose uptake. Metabolism (1992) 0.86
Effects of fasting on plasma glucose and prolonged tracer measurement of hepatic glucose output in NIDDM. Diabetes (1987) 0.86
Clinical breast evaluation skills of house officers and students. Am Surg (1996) 0.86
General practitioner participants in a telemedicine trial: comparisons with their peers. J Telemed Telecare (2001) 0.85
Virtual outreach: a telemedicine pilot study using a cluster-randomized controlled design. J Telemed Telecare (1999) 0.85
Fasting decreases rates of noninsulin-mediated glucose uptake in man. J Clin Endocrinol Metab (1988) 0.84