Published in Am J Pathol on June 01, 1987
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Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques. Am J Pathol (1988) 1.26
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Rat amylin: cloning and tissue-specific expression in pancreatic islets. Proc Natl Acad Sci U S A (1989) 1.14
Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol (2004) 1.12
Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging (2008) 1.03
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Formation of partially ordered oligomers of amyloidogenic hexapeptide (NFGAIL) in aqueous solution observed in molecular dynamics simulations. Biophys J (2004) 1.00
Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies. Sci Rep (2014) 0.98
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The role of Phe in the formation of well-ordered oligomers of amyloidogenic hexapeptide (NFGAIL) observed in molecular dynamics simulations with explicit solvent. Biophys J (2005) 0.92
Amyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure. Exp Diabetes Res (2009) 0.90
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Phenol red interacts with the protofibril-like oligomers of an amyloidogenic hexapeptide NFGAIL through both hydrophobic and aromatic contacts. Biophys J (2006) 0.87
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The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit. Am J Pathol (1990) 0.87
Islet amyloid polypeptide in proliferating pancreatic B cells during development, hyperplasia, and neoplasia in humans and mice. Am J Pathol (1991) 0.86
A feline model of experimentally induced islet amyloidosis. Am J Pathol (2000) 0.84
Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation. PLoS One (2011) 0.83
The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH. Eur Biophys J (2010) 0.81
Incidence of Diabetes Mellitus in Insured Swedish Cats in Relation to Age, Breed and Sex. J Vet Intern Med (2015) 0.81
Prolactin-derived amyloid in the aging pituitary gland. Am J Pathol (1997) 0.80
Immunoreactivity and expression of amylin in gastroenteropancreatic endocrine tumors. Am J Pathol (1993) 0.80
General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. PLoS One (2014) 0.79
The ability of insulin to inhibit the formation of amyloid by pro-islet amyloid polypeptide processing intermediates is significantly reduced in the presence of sulfated glycosaminoglycans. Biochemistry (2014) 0.79
Amylin-mediated control of glycemia, energy balance, and cognition. Physiol Behav (2016) 0.78
Analysis of the Ability of Pramlintide To Inhibit Amyloid Formation by Human Islet Amyloid Polypeptide Reveals a Balance between Optimal Recognition and Reduced Amyloidogenicity. Biochemistry (2015) 0.77
A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor. Biochem J (1993) 0.77
Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation. Aging (Albany NY) (2016) 0.77
Preparation and characterization of PEGylated amylin. AAPS PharmSciTech (2013) 0.77
Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. J Biol Chem (2009) 0.77
Secondary Structure of Rat and Human Amylin across Force Fields. PLoS One (2015) 0.76
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A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun (1986) 2.24
Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid. J Exp Med (1976) 1.91
Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression. Proc Natl Acad Sci U S A (1985) 1.62
A second human calcitonin/CGRP gene. FEBS Lett (1985) 1.60
Fine structure of islets of Langerhans in insular amyloidosis. Virchows Arch A Pathol Pathol Anat (1973) 1.45
Amyloid in polypeptide hormone-producing tumors. Lab Invest (1977) 1.45
Hyalinization of the islets of Langerhans in nondiabetic individuals. Am J Pathol (1959) 1.41
Feline insular amyloid: association with diabetes mellitus. Vet Pathol (1981) 1.36
An analysis of the close relationship of lysosomes to early deposits of amyloid. Ultrastructural evidence in experimental mouse amyloidosis. Am J Pathol (1973) 1.22
Immunocytochemical identification of islet cells and nerve fibers containing calcitonin gene-related peptide-like immunoreactivity in the rat pancreas. Gastroenterology (1986) 1.10
Feline insular amyloid: incidence in adult cats with no clinicopathologic evidence of overt diabetes mellitus. Vet Pathol (1981) 1.10
Islet amyloid in Type 2 (non-insulin-dependent) diabetes is related to insulin. Diabetologia (1983) 1.07
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Amyloid of medullary carcinoma of the thyroid; partial characterization. Ups J Med Sci (1975) 1.00
Identification of calcitonin and calcitonin gene-related peptide messenger ribonucleic acid in medullary thyroid carcinomas by hybridization histochemistry. J Clin Endocrinol Metab (1986) 0.93
Quantitative distribution of calcitonin gene-related peptide in the rat central nervous system. Peptides (1986) 0.86
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci U S A (1987) 4.53
Improvement of an "In-Gel" digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing. Anal Biochem (1995) 4.49
Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. J Biol Chem (1988) 3.98
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (1989) 3.80
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci U S A (1990) 3.29
No apology for geriatrics. Br Med J (1973) 2.71
A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature (1986) 2.58
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma. EMBO J (1992) 2.47
TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Cell (1990) 2.46
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J Biol Chem (1997) 2.39
The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia (1978) 2.31
Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem (1998) 2.25
A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun (1986) 2.24
Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlation. Am J Med (1983) 2.13
Evidence that the amyloid fibril protein in senile systemic amyloidosis is derived from normal prealbumin. Biochem Biophys Res Commun (1988) 2.13
Absorption and circular dichroism spectroscopy of nucleic acid duplexes and triplexes. Methods Enzymol (1995) 2.08
Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid. J Exp Med (1976) 1.91
Senile cardiac amyloid is related to prealbumin. Scand J Immunol (1980) 1.86
The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases. J Biol Chem (1995) 1.86
Staining methods for identification of amyloid in tissue. Methods Enzymol (1999) 1.80
The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies. J Intern Med (2004) 1.74
Senile systemic amyloidosis. Am J Pathol (1984) 1.69
Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species. FEBS Lett (1989) 1.68
Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia (1989) 1.66
Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient. Diabetologia (1988) 1.60
Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site. Oncogene (2006) 1.59
Nomenclature of amyloid fibril proteins. Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9, 1998. Part 1. Amyloid (1999) 1.59
Acceleration of amyloid protein A amyloidosis by amyloid-like synthetic fibrils. Proc Natl Acad Sci U S A (1998) 1.58
Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. Neuron (1995) 1.56
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Effects of dietary protein and calorie restriction in clinically normal cats and in cats with surgically induced chronic renal failure. Am J Vet Res (1993) 1.54
Senile cardiac amyloidosis: evidence of two different amyloid substances in the ageing heart. Scand J Immunol (1979) 1.48
Fine structure of islets of Langerhans in insular amyloidosis. Virchows Arch A Pathol Pathol Anat (1973) 1.45
Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities. Growth Factors (1989) 1.45
Amyloid in polypeptide hormone-producing tumors. Lab Invest (1977) 1.45
'Amylin' hormone. Nature (1989) 1.44
The pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults. Acta Pathol Microbiol Scand A (1973) 1.43
Quantitative studies on amyloid in the islets of Langerhans. Ups J Med Sci (1972) 1.42
A new method for the diagnosis of systemic amyloidosis. Arch Intern Med (1973) 1.38
Amyloid in basal cell carcinoma and seborrheic keratosis. Acta Derm Venereol (1994) 1.38
Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis. EMBO J (1996) 1.37
Feline insular amyloid: association with diabetes mellitus. Vet Pathol (1981) 1.36
The mechanism of force generation in myosin: a disorder-to-order transition, coupled to internal structural changes. Biophys J (1995) 1.36
Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion. Am J Pathol (1982) 1.36
Identification and characterization of different amyloid fibril proteins in tissue sections. Scand J Immunol (1977) 1.33
Tumorigenesis by Millipore filters in mice: histology and ultrastructure of tissue reactions as related to pore size. J Natl Cancer Inst (1973) 1.33
Senile cardiac amyloid: evidence that fibrils contain a protein immunologically related to prealbumin. Immunology (1981) 1.30
Feline mammary hypertrophy/fibroadenoma complex: clinical and hormonal aspects. Am J Vet Res (1981) 1.30
Characterization of an amyloid fibril protein from senile cardiac amyloid. J Exp Med (1977) 1.30
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Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon (1995) 1.27
Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques. Am J Pathol (1988) 1.26
Normal transthyretin and synthetic transthyretin fragments form amyloid-like fibrils in vitro. Biochem Biophys Res Commun (1991) 1.25
Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid. Proc Natl Acad Sci U S A (1999) 1.24
Molecular cloning and expression of a 58-kDa cis-Golgi and intermediate compartment protein. J Biol Chem (1996) 1.24
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The P-component of amyloid of human islets of langerhans. Scand J Immunol (1975) 1.20
Chemical typing of amyloid protein contained in formalin-fixed paraffin-embedded biopsy specimens. Am J Clin Pathol (2001) 1.19
Islet amyloid polypeptide (IAPP):cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus. Exp Cell Res (1989) 1.19
Fibrils from synthetic amyloid-related peptides enhance development of experimental AA-amyloidosis in mice. Biochem Biophys Res Commun (1994) 1.18
Dissociated secretion of islet amyloid polypeptide and insulin in serum-free culture media conditioned by human pancreatic adenocarcinoma cell lines. Int J Pancreatol (1997) 1.17
Light and electron microscopic studies of islet amyloid in diabetic cats. Diabetes (1973) 1.15
Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM). FEBS Lett (1993) 1.15
Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. N Engl J Med (1994) 1.14
Two different 8 kDa monomers are involved in the oligomeric organization of the native Echinococcus granulosus antigen B. Parasite Immunol (1996) 1.12
The retinal pigment epithelial membrane receptor for plasma retinol-binding protein. Isolation and cDNA cloning of the 63-kDa protein. J Biol Chem (1993) 1.12
Immunohistochemical evidence for the lack of amyloid P component in some intracerebral amyloids. Lab Invest (1982) 1.11
Islet amyloid polypeptide-like immunoreactivity in the islet B cells of type 2 (non-insulin-dependent) diabetic and non-diabetic individuals. Diabetologia (1987) 1.10
Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus. N Engl J Med (1989) 1.10
Feline insular amyloid: incidence in adult cats with no clinicopathologic evidence of overt diabetes mellitus. Vet Pathol (1981) 1.10
The N-terminal segment of protein AA determines its fibrillogenic property. Biochem Biophys Res Commun (1992) 1.09
Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. J Biol Chem (1993) 1.09
Spontaneous diabetes mellitus-islet amyloid complex in adult cats. Am J Pathol (1986) 1.08
Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis. J Clin Endocrinol Metab (1996) 1.08
Islet amyloid in Type 2 (non-insulin-dependent) diabetes is related to insulin. Diabetologia (1983) 1.07
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets. Diabetologia (2006) 1.07
Enhanced in vitro production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide. Amyloid (2001) 1.07
Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP. Mol Med (2000) 1.07
Further characterization and partial amino acid sequence of a cysteine proteinase from Trypanosoma cruzi. Mol Biochem Parasitol (1989) 1.07
Islet amyloid polypeptide in human insulinomas. Evidence for intracellular amyloidogenesis. Diabetes (1994) 1.07
Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis. J Pathol (2008) 1.06
Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem Biophys Res Commun (1998) 1.05