Published in Methods Enzymol on January 01, 1987
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Significance of two distinct types of tryptophan synthase beta chain in Bacteria, Archaea and higher plants. Genome Biol (2001) 1.06
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Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proc Natl Acad Sci U S A (2008) 1.01
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A comparative study of the kinetics and stereochemistry of the serine hydroxymethyltransferase- and tryptophan synthase-catalysed exchange of the pro-2R and pro-2S protons of glycine. Biochem J (1991) 0.86
Factors affecting the stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the pro-2R and pro-2S protons of glycine. Biochem J (1995) 0.82
The effect of different amino acid side chains on the stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids. Biochem J (1996) 0.82
Long-observation-window band-selective homonuclear decoupling: increased sensitivity and resolution in solid-state NMR spectroscopy of proteins. J Magn Reson (2013) 0.81
Catalytic roles of βLys87 in tryptophan synthase: (15)N solid state NMR studies. Biochim Biophys Acta (2015) 0.79
Solubilization and renaturation of overexpressed aggregates of mutant tryptophan synthase alpha-subunits. Appl Environ Microbiol (1989) 0.78
Role of proteases and antiprotease in the etiology of chronic pancreatitis. Saudi J Gastroenterol (2012) 0.76
NMR Crystallography of a Carbanionic Intermediate in Tryptophan Synthase: Chemical Structure, Tautomerization, and Reaction Specificity. J Am Chem Soc (2016) 0.75
The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids. Biochem J (2004) 0.75
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Modification of histidyl residues in proteins by diethylpyrocarbonate. Methods Enzymol (1977) 4.25
Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium. J Biol Chem (1988) 3.52
Intracellular concentrations of water and of the principal electrolytes determined by analysis of isolated human leucocytes. Clin Sci (1969) 2.42
Pressure dissociation and conformational drift of the beta dimer of tryptophan synthase. Biochemistry (1986) 2.12
Identification of amino acid residues involved in feedback regulation of the anthranilate synthase complex from Salmonella typhimurium. Evidence for an amino-terminal regulatory site. J Biol Chem (1991) 2.00
Blood pre-donation deferrals--a teaching hospital experience. Southeast Asian J Trop Med Public Health (2008) 1.58
Tryptophan synthase: structure, function, and subunit interaction. Adv Enzymol Relat Areas Mol Biol (1979) 1.41
Anthranilate synthase-anthranilate phosphoribosyltransferase complex and subunits of Salmonella typhimurium. Methods Enzymol (1987) 1.36
Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation. Biochemistry (2000) 1.27
The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Proc Natl Acad Sci U S A (1999) 1.26
Mutational analysis of the catalytic and feedback sites of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli. J Bacteriol (1988) 1.22
Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein. J Biol Chem (2000) 1.17
Estrogen increases the number of plasma cells and enhances their autoantibody production in nonautoimmune C57BL/6 mice. Cell Immunol (1998) 1.15
Velocity measurements in steady flow through axisymmetric stenoses at moderate Reynolds numbers. J Biomech (1983) 1.13
Characterization of composite aminodeoxyisochorismate synthase and aminodeoxyisochorismate lyase activities of anthranilate synthase. Proc Natl Acad Sci U S A (1993) 1.12
The beta subunit of tryptophan synthase. Clarification of the roles of histidine 86, lysine 87, arginine 148, cysteine 170, and cysteine 230. J Biol Chem (1989) 1.11
Structure of NADH peroxidase from Streptococcus faecalis 10C1 refined at 2.16 A resolution. J Mol Biol (1991) 1.11
A dye-based lymphocyte proliferation assay that permits multiple immunological analyses: mRNA, cytogenetic, apoptosis, and immunophenotyping studies. J Immunol Methods (1997) 1.11
Expression, purification, and efficacy of the type A botulinum neurotoxin catalytic domain fused to two translocation domain variants. Toxicon (2003) 1.10
Congenital chloride diarrhoea in Kuwaiti children. Eur J Pediatr (1989) 1.04
Serine modulates substrate channeling in tryptophan synthase. A novel intersubunit triggering mechanism. J Biol Chem (1991) 1.04
Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes. Biochemistry (1997) 1.03
Subunit communication in the anthranilate synthase complex from Salmonella typhimurium. Science (1991) 1.03
Thyroid transplantation developing autoimmune thyroiditis following thymectomy and irradiation. Clin Exp Immunol (1981) 1.00
Combination hyperthermia and radiation therapy for malignant melanoma. Cancer (1982) 1.00
Analysis of avian lymphocyte proliferation by a new, simple, nonradioactive assay (lympho-pro). Avian Dis (1997) 0.99
Photoinactivation and photoaffinity labeling of tryptophan synthase alpha 2 beta 2 complex by the product analogue 6-azido-L-tryptophan. Biochemistry (1985) 0.99
An active proteolytic derivative of the alpha subunit of tryptophan synthase. Identification of the site of cleavage and characterization of the fragments. Biochemistry (1979) 0.99
Sex hormones and the immune system--Part 2. Animal data. Baillieres Clin Rheumatol (1990) 0.98
Response rate of Malaysian blood donors with reactive screening test to transfusion medicine unit calls. Southeast Asian J Trop Med Public Health (2009) 0.98
Ligand-mediated changes in the tryptophan synthase indole tunnel probed by nile red fluorescence with wild type, mutant, and chemically modified enzymes. J Biol Chem (1995) 0.97
Vitamin-D-deficiency rickets in Kuwait: the prevalence of a preventable disease. Ann Trop Paediatr (1989) 0.97
Analysis of the metal requirement of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. J Biol Chem (1991) 0.96
A new thiol-dependent transamination reaction catalyzed by the B protein of Escherichia coli tryptophan synthetase. Biochemistry (1968) 0.96
The antimicrobial activity of garlic and onion extracts. Pharmazie (1983) 0.95
Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone. J Clin Invest (1985) 0.95
Investigation of allosteric linkages in the regulation of tryptophan synthase: the roles of salt bridges and monovalent cations probed by site-directed mutation, optical spectroscopy, and kinetics. Biochemistry (2001) 0.94
Evidence that mutations in a loop region of the alpha-subunit inhibit the transition from an open to a closed conformation in the tryptophan synthase bienzyme complex. J Biol Chem (1992) 0.94
Crystalline alpha2 beta2 complexes of tryptophan synthetase of Escherichia coli. A comparison between the native complex and the reconstituted complex. J Biol Chem (1974) 0.94
Characterization of the functional role of a flexible loop in the alpha-subunit of tryptophan synthase from Salmonella typhimurium by rapid-scanning, stopped-flow spectroscopy and site-directed mutagenesis. Biochemistry (1993) 0.93
Zidovudine induced pure red cell aplasia: a case report. Niger J Med (2010) 0.93
17 beta-estradiol, but not 5 alpha-dihydrotestosterone, augments antibodies to double-stranded deoxyribonucleic acid in nonautoimmune C57BL/6J mice. Endocrinology (1994) 0.93
Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates. Biochemistry (1996) 0.91
Mechanisms contributing to myocardial accumulation of technetium-99m stannous pyrophosphate after coronary arterial occlusion. Am J Cardiol (1977) 0.91
The tryptophan synthase multienzyme complex: exploring structure-function relationships with X-ray crystallography and mutagenesis. Biotechnology (N Y) (1990) 0.90
Threonine 183 and adjacent flexible loop residues in the tryptophan synthase alpha subunit have critical roles in modulating the enzymatic activities of the beta subunit in the alpha 2 beta 2 complex. J Biol Chem (1992) 0.89
Modification of essential histidyl residues of the beta 2 subunit of tryptophan synthetase by photo-oxidation in the presence of pyridoxal 5'-phosphate and L-serine and by diethylpyrocarbonate. J Biol Chem (1974) 0.89
Recommendations for water supply in arsenic mitigation: a case study from Bangladesh. Public Health (2000) 0.89
Guanidine hydrochloride induced unfolding of the alpha subunit of tryptophan synthase and of the two alpha proteolytic fragments: evidence for stepwise unfolding of the two alpha domains. Biochemistry (1982) 0.89
Lysine 87 in the beta subunit of tryptophan synthase that forms an internal aldimine with pyridoxal phosphate serves critical roles in transimination, catalysis, and product release. J Biol Chem (1993) 0.89
Essential cysteines in 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. Analysis by chemical modification and site-directed mutagenesis of the phenylalanine-sensitive isozyme. J Biol Chem (1992) 0.89
Evidence for a vesicle-mediated maintenance of store-operated calcium channels in a human embryonic kidney cell line. Cell Calcium (2000) 0.88
Folding of homologous proteins: conservation of the folding mechanism of the alpha subunit of tryptophan synthase from Escherichia coli, Salmonella typhimurium, and five interspecies hybrids. Biochemistry (1988) 0.88
Extramedullary hematopoiesis in hereditary spherocytosis deficient in ankyrin: a case report. Int J Hematol (2002) 0.88
Exchange of K+ or Cs+ for Na+ induces local and long-range changes in the three-dimensional structure of the tryptophan synthase alpha2beta2 complex. Biochemistry (1996) 0.87
Purification and properties of tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. J Bacteriol (1991) 0.87
Adolescent abuse in a community sample in Beni Suef, Egypt: prevalence and risk factors. East Mediterr Health J (2006) 0.87
Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the beta-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium. Biochemistry (1992) 0.87
The reaction of yeast cystathionine beta-synthase is rate-limited by the conversion of aminoacrylate to cystathionine. Biochemistry (2001) 0.87
Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosugar epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase. J Biol Chem (1994) 0.86
The influence of testosterone on the development of autoimmune thyroiditis in thymectomized and irradiated rats. Clin Exp Immunol (1982) 0.86
Pulsatile poststenotic flow studies with laser Doppler anemometry. J Biomech (1984) 0.86
Flow disturbance measurements through a constricted tube at moderate Reynolds numbers. J Biomech (1983) 0.86
CD5 B cells in autoimmunity. Ann N Y Acad Sci (1992) 0.86
Comparison of multiple assays for kinetic detection of apoptosis in thymocytes exposed to dexamethasone or diethylstilbesterol. Cytometry (1999) 0.86
Microspectrophotometric studies on single crystals of the tryptophan synthase alpha 2 beta 2 complex demonstrate formation of enzyme-substrate intermediates. J Biol Chem (1989) 0.86
Tryptophan synthase alpha subunit glutamic acid 49 is essential for activity. Studies with 19 mutants at position 49. J Biol Chem (1987) 0.86
Hematological reference values of healthy Malaysian population. Int J Lab Hematol (2008) 0.86
Interactions of tryptophan synthase, tryptophanase, and pyridoxal phosphate with oxindolyl-L-alanine and 2,3-dihydro-L-tryptophan: support for an indolenine intermediate in tryptophan metabolism. Biochemistry (1984) 0.85
A new type of pyridoxal-P enzyme catalyzed reaction: the conversion of beta, gamma-unsaturated amino acids to saturated alpha-keto acids by tryptophan synthase. Biochem Biophys Res Commun (1975) 0.85
Pathological changes in inbred strains of mice following early thymectomy and irradiation. Experientia (1981) 0.85
PCR mutagenesis and overexpression of tryptophan synthase from Salmonella typhimurium: on the roles of beta2 subunit Lys-382. Protein Expr Purif (1996) 0.85
The B protein of Escherichia coli tryptophan synthetase. II. New -elimination and -replacement reactions. Biochem Biophys Res Commun (1971) 0.84
Regulation of tryptophan synthase by temperature, monovalent cations, and an allosteric ligand. Evidence from Arrhenius plots, absorption spectra, and primary kinetic isotope effects. Biochemistry (2000) 0.84
Evaluation of serological transfusion-transmitted viral diseases and mutliplex nucleic acid testing in malaysian blood donors. Transfus Apher Sci (2013) 0.84
Aliphatic alcohols stabilize an alternative conformation of the tryptophan synthase alpha 2 beta 2 complex from Salmonella typhimurium. J Biol Chem (1994) 0.84
The B protein of Escherichia coli tryptophan synthetase. I. Effects of sulfhydryl modification on enzymatic activities and subunit interaction. J Biol Chem (1970) 0.84
Using phenothiazines to detect micro amounts of blood in urine. Clin Chem (1981) 0.84
Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity. Biochemistry (2001) 0.83
Effect of single amino acid substitutions at positions 49 and 60 on the thermal unfolding of the tryptophan synthase alpha subunit from Salmonella typhimurium. Arch Biochem Biophys (1991) 0.83
The association of increased plasma MB CPK activity and irreversible ischemic myocardial injury in the dog. Circulation (1976) 0.83
Mechanism of mutual activation of the tryptophan synthase alpha and beta subunits. Analysis of the reaction specificity and substrate-induced inactivation of active site and tunnel mutants of the beta subunit. J Biol Chem (1991) 0.83
Temporal lobe involvement in Japanese encephalitis: problems in differential diagnosis. AJNR Am J Neuroradiol (2006) 0.82
Intracellular pH measured in isolated normal human leucocytes, by using 5,5-dimethyl-2,4-oxazolidinedione under conditions of varying extracellular PCo 2 NS BICARBONATE. Clin Sci (1971) 0.82
Tryptophan synthase of Escherichia coli. Removal of pyridoxal 5'-phosphate and separation of the alpha and beta2 subunits. J Biol Chem (1977) 0.82
Guanidine hydrochloride exerts dual effects on the tryptophan synthase alpha 2 beta 2 complex as a cation activator and as a modulator of the active site conformation. Biochemistry (1999) 0.82