Published in J Clin Invest on March 01, 1988
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest (1992) 3.40
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest (1990) 2.92
Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. J Clin Invest (1999) 1.67
Molecular imaging of cancer with copper-64 radiopharmaceuticals and positron emission tomography (PET). Acc Chem Res (2009) 1.49
The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. J Clin Invest (2004) 1.45
Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen. J Clin Invest (2000) 1.30
Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture. J Clin Invest (2000) 1.30
Hypercalcemia of malignancy revisited. J Clin Invest (1988) 1.26
Hypercalcemia in malignancy. West J Med (1990) 1.24
Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide. J Nucl Med (2007) 1.10
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. J Clin Invest (1991) 1.07
Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors. J Clin Invest (1988) 1.01
Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability. Biochem J (1995) 0.96
High levels of a parathyroid hormone-like protein in milk. Proc Natl Acad Sci U S A (1989) 0.94
Effective treatment of malignant hypercalcaemia with a single intravenous infusion of clodronate. Br J Cancer (1993) 0.92
Abundant expression of parathyroid hormone-related protein in primary rat aortic smooth muscle cells accompanies serum-induced proliferation. J Clin Invest (1991) 0.91
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest (2013) 0.88
Hypoxia, stem cells and bone tumor. Cancer Lett (2011) 0.86
Dose-response study of ibandronate in the treatment of cancer-associated hypercalcaemia. Br J Cancer (1997) 0.85
Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake. Am J Physiol Endocrinol Metab (2012) 0.82
Incidence and pathophysiology of hypercalcemia. Calcif Tissue Int (1990) 0.79
Distribution of the parathyroid hormone-related peptide and its receptor in the saccus vasculosus and choroid plexus in the red stingray (Dasyatis akajei: Elasmobranch). Cell Mol Neurobiol (1998) 0.77
Hypercalcaemia and hypocalcaemia: finding the balance. Support Care Cancer (2017) 0.75
Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1-17. Oncogene (2017) 0.75
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science (1987) 4.09
Radioimmunoassay of cyclic AMP and cyclic GMP. Adv Cyclic Nucleotide Res (1979) 3.54
Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. N Engl J Med (1980) 3.15
Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci U S A (1987) 3.06
BONE RESORPTION IN TISSUE CULTURE. FACTORS INFLUENCING THE RESPONSE TO PARATHYROID HORMONE. J Clin Invest (1965) 2.55
Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest (1987) 2.41
Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J Biol Chem (1987) 2.30
Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases. N Engl J Med (1973) 1.99
Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest (1983) 1.77
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. Proc Natl Acad Sci U S A (1983) 1.75
Quantitative bone histomorphometry in humoral hypercalcemia of malignancy: uncoupling of bone cell activity. J Clin Endocrinol Metab (1982) 1.68
Monitoring of solid phase peptide synthesis by an automated spectrophotometric picrate method. Anal Biochem (1975) 1.52
N-terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: identification of parathyroid hormone-like and parathyroid hormone-unlike domains. Biochem Biophys Res Commun (1987) 1.51
Mechanism of malignant hypercalcaemia in carcinoma of the breast. Br Med J (Clin Res Ed) (1985) 1.45
Gammaflow: a completely automated radioimmunoassay system. Science (1976) 1.39
Tumor products and the hypercalcemia of malignancy. J Clin Invest (1985) 1.37
Hypercalcaemia of malignancy: evidence for a nonparathyroid humoral agent with an effect on renal tubular handling of calcium. Clin Sci (Lond) (1984) 1.36
Absence of parathyroid hormone messenger RNA in nonparathyroid tumors associated with hypercalcemia. N Engl J Med (1983) 1.27
PTH sensitive adenyl cyclase activity in different segments of the rabbit nephron. Pflugers Arch (1975) 1.26
Purification of peptides with parathyroid hormone-like bioactivity from human and rat malignancies associated with hypercalcemia. Endocrinology (1986) 1.18
Role of bone and kidney in tumor-induced hypercalcemia and its treatment with bisphosphonate and sodium chloride. Am J Med (1987) 1.13
Urinary and nephrogenous adenosine 3',5'-monophosphate in the hypercalcemia of malignancy. J Clin Endocrinol Metab (1981) 1.06
Quantitative bone histology in the hypercalcemia of malignant disease. J Clin Endocrinol Metab (1982) 0.90
Alterations in hormone-sensitive adenylate cyclase of cloned rat osteosarcoma cells during long-term culture. J Bone Miner Res (1986) 0.83
Adenylate cyclase of osteoblast-like cells from rat osteosarcoma is stimulated by calcitonin as well as parathyroid hormone. Endocrinology (1984) 0.81
Use of osmotic minipumps for delivery of parathyroid hormone. Calcif Tissue Int (1982) 0.79
Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature (1986) 5.68
Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev (1997) 5.65
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest (1999) 5.30
Metastatic prostate cancer in a transgenic mouse. Cancer Res (1996) 4.02
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest (1996) 3.44
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest (1992) 3.40
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res (1995) 3.23
Characterization of a gamma-carboxyglutamic acid-containing protein from bone. Proc Natl Acad Sci U S A (1976) 3.15
Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med (1974) 2.97
Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med (1996) 2.92
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest (1990) 2.92
Mineralisation defects with pamidronate therapy for Paget's disease. Lancet (1993) 2.76
Current use of bisphosphonates in oncology. International Bone and Cancer Study Group. J Clin Oncol (1998) 2.73
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology (1988) 2.60
Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption. J Immunol (1987) 2.59
Establishment of an osteocyte-like cell line, MLO-Y4. J Bone Miner Res (1997) 2.55
The hypercalcemia of cancer. Clinical implications and pathogenic mechanisms. N Engl J Med (1984) 2.33
Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest (2003) 2.30
A method for decarboxylation of gamma-carboxyglutamic acid in proteins. Properties of the decarboxylated gamma-carboxyglutamic acid protein from calf bone. J Biol Chem (1979) 2.30
Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones. Proc Natl Acad Sci U S A (1987) 2.29
Identification of an essential glutamic acid residue in the beta subunit of the adenosine triphosphatase from the thermophilic bacterium PS3. J Biol Chem (1981) 2.19
Primary hyperparathyroidism: changes in the pattern of clinical presentation. Lancet (1980) 2.19
Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol (1998) 2.17
Bone-resorbing activity in supernatants from lymphoid cell lines. N Engl J Med (1974) 2.08
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev (1997) 2.08
Effects of interleukin-1 on bone turnover in normal mice. Endocrinology (1989) 2.06
The hypercalcemia of malignancy: pathogenesis and management. Metabolism (1982) 2.01
Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res (1995) 1.97
Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro. J Immunol (1986) 1.93
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci U S A (1993) 1.92
Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro. J Bone Miner Res (1989) 1.87
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. J Clin Invest (1983) 1.84
Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. N Engl J Med (1987) 1.82
Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest (1995) 1.79
MEPE has the properties of an osteoblastic phosphatonin and minhibin. Bone (2004) 1.79
Decreased c-Src expression enhances osteoblast differentiation and bone formation. J Cell Biol (2000) 1.77
Cancer and bone. Endocr Rev (1998) 1.77
Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proc Natl Acad Sci U S A (1986) 1.69
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest (1995) 1.68
Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. J Clin Invest (1999) 1.67
Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures. J Bone Miner Res (1986) 1.64
Osteolytic bone metastasis in breast cancer. Breast Cancer Res Treat (1994) 1.61
Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity. Blood (2000) 1.59
Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone. Proc Natl Acad Sci U S A (1976) 1.58
Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. J Cell Biol (1995) 1.58
The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases. Cancer Res (2001) 1.57
Activation of the bone-derived latent TGF beta complex by isolated osteoclasts. Biochem Biophys Res Commun (1989) 1.56
Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology (1991) 1.56
Role of transforming growth factor-beta in bone remodeling. Clin Orthop Relat Res (1990) 1.55
Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem (1998) 1.54
The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. J Clin Invest (1995) 1.53
Alteration of vitamin D metabolism in Mexican-Americans. J Bone Miner Res (1990) 1.53
A murine model of human myeloma bone disease. Bone (1997) 1.53
Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy. Science (1983) 1.52
Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Calcif Tissue Int (1997) 1.51
Cardiac abnormalities in poisoning with tricyclic antidepressants. Br Med J (1969) 1.50
Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J Clin Invest (1997) 1.49
Pathogenesis of hypercalcemia in lymphosarcoma cell leukemia. Role of an osteoclast activating factor-like substance and a mechanism of action for glucocorticoid therapy. Am J Med (1978) 1.47
Formation of multinucleated cells that respond to osteotropic hormones in long term human bone marrow cultures. Endocrinology (1987) 1.46
Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease. Lancet (1984) 1.45
Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res (1994) 1.44
Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids. Metab Bone Dis Relat Res (1984) 1.42
Effects of transforming growth factor-beta on osteoblastic osteosarcoma cells. Endocrinology (1987) 1.42
Direct stimulation of bone resorption by thyroid hormones. J Clin Invest (1976) 1.42
Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo. J Bone Miner Res (2000) 1.42
Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures. J Clin Invest (1986) 1.41
Ibandronate reduces osteolytic lesions but not tumor burden in a murine model of myeloma bone disease. Blood (1999) 1.40
A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res (1996) 1.40
Tumor products and the hypercalcemia of malignancy. J Clin Invest (1985) 1.37
Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein. J Biol Chem (1994) 1.37
Human Curvularia infections. Report of five cases and review of the literature. Diagn Microbiol Infect Dis (1987) 1.34
Dietary restriction alters characteristics of glucose fuel use. J Gerontol (1992) 1.34
Direct resorption of bone by human breast cancer cells in vitro. Nature (1978) 1.33
Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice. Endocrinology (1996) 1.32
Monocytes regulate osteoclast-activating factor production by releasing prostaglandins. J Exp Med (1979) 1.32
E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res (1996) 1.30
Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha. Science (1985) 1.27
1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow. Proc Natl Acad Sci U S A (1985) 1.27
Absence of parathyroid hormone messenger RNA in nonparathyroid tumors associated with hypercalcemia. N Engl J Med (1983) 1.27
Expression of bone morphogenetic protein messenger RNA in prolonged cultures of fetal rat calvarial cells. J Bone Miner Res (1994) 1.26
Resorbing bone is chemotactic for monocytes. Nature (1978) 1.26
Relationship of sex hormones to lipids and lipoproteins in nondiabetic men. J Clin Endocrinol Metab (1993) 1.24
The pulpal response to topically applied citric acid. Oral Surg Oral Med Oral Pathol (1984) 1.22
Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells. J Cell Biol (1984) 1.22
Scanning electron microscopy in bone pathology: review of methods, potential and applications. Scan Electron Microsc (1986) 1.21
Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice. Proc Natl Acad Sci U S A (1988) 1.20
Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures. Proc Natl Acad Sci U S A (1988) 1.20
Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue. J Biol Chem (1980) 1.19