Published in Jpn J Pharmacol on January 01, 1988
Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice. Proc Natl Acad Sci U S A (1999) 1.17
Analgesic tolerance to morphine is regulated by PPARγ. Br J Pharmacol (2014) 0.79
Multiple nutritional requirements of lactobacilli: genetic lesions affecting amino acid biosynthetic pathways. J Bacteriol (1981) 2.62
Occurrence of tetrodotoxin and anhydrotetrodotoxin in Vibrio sp. isolated from the intestines of a xanthid crab, Atergatis floridus. J Biochem (1986) 2.56
Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes (2001) 1.81
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma. Oncogene (2000) 1.76
The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells. Diabetes (1996) 1.72
Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest (1997) 1.64
Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun (2003) 1.27
Acute health problems among the people engaged in the cleanup of the Nakhodka oil spill. Environ Res (1999) 1.23
Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J Pharmacobiodyn (1987) 1.18
Increased stress protein ORP150 autoantibody production in Type 1 diabetic patients. Diabet Med (2006) 1.13
Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription. Biochem Biophys Res Commun (1996) 1.11
Physical fitness of paraplegics in full wheelchair marathon racing. Paraplegia (1985) 1.11
Increased oxidative stress in childhood atopic dermatitis. Life Sci (2001) 1.03
Location of an inducible nitric oxide synthase mRNA in the normal kidney. Kidney Int (1994) 1.03
Identification of Aeromonas species isolated from freshwater fish with the microplate hybridization method. Appl Environ Microbiol (1994) 1.00
Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia. Jpn J Pharmacol (1990) 1.00
Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes. Diabetologia (2004) 1.00
A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. J Biol Chem (1994) 0.99
Vibrio sp. strain NM 10, isolated from the intestine of a Japanese coastal fish, has an inhibitory effect against Pasteurella piscicida. Appl Environ Microbiol (1997) 0.99
Influence of galactooligosaccharides on the human fecal microflora. J Nutr Sci Vitaminol (Tokyo) (1993) 0.97
Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists. Life Sci (1997) 0.95
Interleukin 6 and expression of its receptor on epidermal keratinocytes. Cytokine (1990) 0.95
Production of amylase by the intestinal microflora in cultured freshwater fish. Lett Appl Microbiol (1997) 0.95
TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase. Free Radic Biol Med (1997) 0.94
Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors. Bioconjug Chem (1999) 0.93
Evaluation of gut motility in type II diabetes by the radiopaque marker method. J Gastroenterol Hepatol (2000) 0.93
Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori. Drug Deliv (2001) 0.92
Pharmacologic studies on analgesics. VII. Significance of the calcium ion in morphine analgesia. J Pharmacol Exp Ther (1966) 0.91
Regulation and mechanisms of gene amplification. Philos Trans R Soc Lond B Biol Sci (1995) 0.91
In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem Pharmacol (1994) 0.89
Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas. Mol Cell Biol (1999) 0.88
Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes. Osteoarthritis Cartilage (2004) 0.88
Involvement of glycation and oxidative stress in diabetic macroangiopathy. Diabetes (1996) 0.88
Exposure of Greenlandic Inuit to organochlorines and heavy metals through the marine food-chain: an international study. Sci Total Environ (1996) 0.86
Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats. Biochem J (1996) 0.86
Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells. J Clin Invest (1997) 0.84
Distribution of Aeromonas species in the intestinal tracts of river fish. Appl Environ Microbiol (1995) 0.84
The contribution of fructose and nitric oxide to oxidative stress in hamster islet tumor (HIT) cells through the inactivation of glutathione peroxidase. Electrophoresis (2000) 0.84
Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract (2011) 0.83
Antibodies to BSA conjugates of morphine derivatives: strict dependency of the immunological specificity on the hapten structure. Jpn J Pharmacol (1974) 0.83
Infrequent widespread microsatellite instability in hepatocellular carcinomas. Int J Oncol (2000) 0.83
Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells. Diabetologia (1999) 0.83
A non-opioid mechanism in the inhibitory effect of ginseng saponins on electrically evoked contractions of guinea-pig ileum and mouse vas deferens. J Pharmacobiodyn (1988) 0.82
Potential roles for two human homeodomain containing proteins in the proliferation and differentiation of human hematopoietic progenitors. Leuk Lymphoma (1993) 0.82
Dramatic recovery of counter-regulatory hormone response to hypoglycaemia after intensive insulin therapy in poorly controlled Type I diabetes mellitus. Diabetologia (1998) 0.82
Important role of adrenergic function in the development of analgesic tolerance to morphine in mice. Jpn J Pharmacol (1986) 0.82
Selenium and fertility in animals and man--a review. Acta Vet Scand (1996) 0.82
Effects of footshock-, psychological- and forced swimming-stress on the learning and memory processes: involvement of opioidergic pathways. Jpn J Pharmacol (1995) 0.81
Identification of oxidative stress-regulated genes in rat aortic smooth muscle cells by suppression subtractive hybridization. FEBS Lett (1999) 0.81
Application of ozone disinfection to remove Enterococcus seriolicida, Pasteurella piscicida, and Vibrio anguillarum from seawater. Appl Environ Microbiol (1992) 0.81
Effects of transgalactosylated disaccharides on the human intestinal microflora and their metabolism. J Nutr Sci Vitaminol (Tokyo) (1993) 0.81
In vivo measurement by [3H]Tamsulosin of alpha1 adrenoceptors in rat tissues in relation to the pharmacokinetics. J Pharmacol Exp Ther (1999) 0.81
In vivo transport of a dynorphin-like analgesic peptide, E-2078, through the blood-brain barrier: an application of brain microdialysis. Pharm Res (1991) 0.81
Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide. Eur J Pharmacol (1997) 0.81
The Inuit diet. Fatty acids and antioxidants, their role in ischemic heart disease, and exposure to organochlorines and heavy metals. An international study. Arctic Med Res (1996) 0.81
Selenium status and skeletal tissue metabolism in young infants. Eur J Pediatr (1996) 0.80
Role of protein kinase C in cisplatin nephrotoxicity. Int J Urol (1999) 0.80
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. Jpn J Pharmacol (1994) 0.80
Behavioral and pharmacological studies on gluten exorphin A5, a newly isolated bioactive food protein fragment, in mice. Jpn J Pharmacol (2000) 0.80
[Follow-up study related to raising low-birth-weight infants relationship among physical growth, mental development and child-rearing anxiety]. Nihon Koshu Eisei Zasshi (2000) 0.79
Tumor necrosis factor changes sensitivity of differentiation of mouse leukemia M1 cells by lipopolysaccharide. Jpn J Cancer Res (1990) 0.79
Mutation of the Pax6 gene causes impaired glucose-stimulated insulin secretion. Diabetologia (2004) 0.79
Facilitation of memory retrieval by pretest morphine mediated by mu but not delta and kappa opioid receptors. Psychopharmacology (Berl) (1990) 0.79
beta-cell adaptation to hyperglycemia. Diabetes (2001) 0.78
Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract (2011) 0.78
In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain. Pharm Res (2000) 0.78
Evaluation of the polymerase chain reaction method for identification of Vibrio vulnificus isolated from marine environments. J Food Prot (1997) 0.78
[Antinociceptive effects of counterirritants]. Nihon Yakurigaku Zasshi (1994) 0.78
Ex vivo occupancy by tamsulosin of alpha1-adrenoceptors in rat tissues in relation to the plasma concentration. Life Sci (1998) 0.78
Involvement of different mechanisms, opioid and non-opioid forms, in the analgesia induced by footshock (FS) and immobilized-water immersion (IW) stress. Jpn J Pharmacol (1983) 0.78
Induction of differentiation of human leukemia cells by various combinations of cytokines and low-molecular-weight inducers. Chem Pharm Bull (Tokyo) (1990) 0.78
Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants. Jpn J Pharmacol (1993) 0.78
Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients. Diabetologia (2006) 0.78
Differentiation of alcohol and barbital physical dependence. Yakubutsu Seishin Kodo (1986) 0.78
Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors. Psychopharmacology (Berl) (1993) 0.78
Glycation of metal-containing proteins such as Cu,Zn-superoxide dismutase, ceruloplasmin, and ferritin: possible implication for DNA damage in vivo. Contrib Nephrol (1995) 0.78
The morphine 3-glucuronide directed antibody: its immunological specificity and possible use for radioimmunoassay of morphine in urine. Jpn J Pharmacol (1974) 0.78
Characterization of protein kinase C expression in human kidney. Tohoku J Exp Med (1996) 0.78
Participation of GABAergic systems in the production of antinociception by various stresses in mice. Jpn J Pharmacol (1992) 0.77
Physical and personality traits of preschool children in Fuzhou, China: only child vs sibling. Child Care Health Dev (2000) 0.77
FS stress induces long-lasting memory facilitation: involvement of cholinergic pathways. Pharmacol Biochem Behav (1996) 0.77
Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits. J Biochem (1996) 0.77
Relationships between blood selenium concentrations and grasping power, blood pressure, hematcrit, and hemoglobin concentrations in Japanese rural residents. Nihon Eiseigaku Zasshi (1985) 0.77
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis. Biochem Biophys Res Commun (2009) 0.77
Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation. Mech Ageing Dev (1988) 0.77
Differential roles of the adrenal gland in the suppression of morphine antinociceptive tolerance development by alpha- and beta-adrenergic blockers. Jpn J Pharmacol (1991) 0.77
Attenuation of KATP channel-opener induced shortening of repolarization time by alpha 1-adrenoceptor antagonist during ischemia in canine heart. Cardiovasc Drugs Ther (2000) 0.77
Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice. Biol Pharm Bull (1993) 0.77
[Bone mineral density of the lumbar spine and its relation to biological and lifestyle factors in middle-aged and aged Japanese women (Part 1). Relationship of age and menopause to bone mineral density of the lumbar spine measured by dual-energy X-ray absorptiometry]. Nihon Eiseigaku Zasshi (1994) 0.77
Single dose tolerance to the analgesic effect of clonidine and cross-tolerance between morphine and clonidine. Jpn J Pharmacol (1985) 0.77
State dependent and/or direct memory retrieval by morphine in mice. Psychopharmacology (Berl) (1990) 0.77
Effects of Tyr-MIF-1 on stress-induced analgesia and the blockade of development of morphine tolerance by stress in mice. Jpn J Pharmacol (1999) 0.77
High serum coenzyme Q10, positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study. Biofactors (1999) 0.77
1(2H)-isoquinolones as potential antiallergic agents. Chem Pharm Bull (Tokyo) (1983) 0.77
Sex differences in excretion of zenarestat in rat. Xenobiotica (1991) 0.77
High prevalence of glucose intolerance in Japanese patients with peripheral arterial disease. Diabetes Res Clin Pract (2010) 0.77
Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice. J Pharmacobiodyn (1990) 0.77
Participation of an alpha 2-mediated mechanism in the production of forced swimming-stress induced analgesia in mice. J Pharmacobiodyn (1991) 0.77