Published in J Clin Invest on January 01, 1978
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The kinetics of insulin metabolism in diabetes mellitus. Postgrad Med J (1973) 1.09
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Determination of common parameters fo iodothyronine metabolism and distribution in man by noncompartmental analysis. J Clin Endocrinol Metab (1975) 1.05
Derivation of a three compartment model describing disappearance of plasma insulin-131-I in man. J Clin Invest (1969) 1.04
[127-I]- or carrier-free [125-I]monoiodoinsulin. J Biol Chem (1975) 1.01
Immunological and biological properties of iodoinsulin labeled with one or less atoms of iodine per molecule. J Clin Invest (1968) 0.99
Appraisal of the extrapancreatic actions of sulfonylureas. Arch Intern Med (1969) 0.99
Degradation of insulin by isolated rat liver cells. Diabetes (1975) 0.92
Renin, angiotensin, and norepinephrine in alloxan diabetes. Diabetes (1974) 0.91
Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics. Diabetes (1976) 0.90
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Transcapillary escape rate of albumin and plasma volume in short- and long-term juvenile diabetics. Scand J Clin Lab Invest (1973) 0.85
Labelled insulin catabolism and pancreatic responsiveness during long-term exercise in man. Horm Metab Res (1971) 0.83
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The effect of acetylsalicylic acid on TSH and PRL secretion after TRH stimulation in the human. J Clin Endocrinol Metab (1976) 0.83
Insulin disappearance after intravenous injection and its effect on blood glucose in diabetic and non-diabetic children and adults. Clin Sci (1972) 0.83
Some considerations in the preparation of raioiodoinsulin for radioimmunoassay and receptor assay. Diabetes (1976) 0.82
The case for an "abnormal" insulin in diabetes mellitus. Diabetologia (1968) 0.80
Insulin metabolism in chronic uremia and in the anephric state: effect of the dialytic treatment. J Clin Endocrinol Metab (1975) 0.79
Radioimmunoassay of labeled and unlabeled insulin mixtures. J Nucl Biol Med (1977) 0.79
Automatic treatment of radioimmunoassay data: an experimental validation of the results. Clin Chim Acta (1975) 0.79
Metabolism of single-component and high-molecular-weight radioactive insulin in rats. Endocrinology (1976) 0.77
Insulin kinetics after portal and peripheral injection of [125I] insulin. I. Data analysis and modeling. Am J Physiol (1976) 0.77
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Effect of fatty acids on glucose production and utilization in man. J Clin Invest (1983) 4.00
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Insulin resistance in essential hypertension. N Engl J Med (1987) 3.78
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Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia (2003) 2.80
Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia (2005) 2.67
Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia (1982) 2.48
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes (1983) 2.45
Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism (1989) 2.27
Effect of insulin on uric acid excretion in humans. Am J Physiol (1995) 2.25
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci U S A (1978) 2.08
Clinical and biochemical features of muscle dysfunction in subclinical hypothyroidism. J Clin Endocrinol Metab (1997) 2.04
More on the effect of atorvastatin on plasma fibrinogen levels in primary hypercholesterolemia. Atherosclerosis (1999) 1.94
The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes (1985) 1.88
Splanchnic and peripheral disposal of oral glucose in man. Diabetes (1983) 1.82
Roux-en-Y gastric bypass and sleeve gastrectomy: mechanisms of diabetes remission and role of gut hormones. J Clin Endocrinol Metab (2013) 1.82
Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes (1987) 1.76
Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism (1987) 1.76
Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study. Diabetes Obes Metab (2010) 1.76
Obesity and insulin resistance in humans: a dose-response study. Metabolism (1990) 1.74
Coronary hemodynamics and myocardial metabolism in patients with syndrome X: response to pacing stress. J Am Coll Cardiol (1991) 1.68
Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance. Diabetologia (2010) 1.64
Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects. Diabetologia (2005) 1.61
The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes (1992) 1.60
Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study. J Clin Endocrinol Metab (2004) 1.59
Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest (1981) 1.59
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus. Am J Med (1983) 1.59
Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study. Diabetes (2000) 1.57
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1991) 1.57
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care (2001) 1.56
Coronary atherosclerosis in Type II diabetes: angiographic findings and clinical outcome. Diabetologia (2000) 1.54
The role of beta-cell function and insulin sensitivity in the remission of type 2 diabetes after gastric bypass surgery. J Clin Endocrinol Metab (2011) 1.53
Insulin sensitivity, vascular reactivity, and clamp-induced vasodilatation in essential hypertension. Circulation (1997) 1.53
Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion. Diabetologia (2013) 1.51
Management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy. Update regarding the thiazolidinediones. Diabetologia (2008) 1.50
Effect of insulin on the distribution and disposition of glucose in man. J Clin Invest (1985) 1.49
Relation of glucose tolerance to complications of pregnancy in nondiabetic women. N Engl J Med (1986) 1.49
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review. Diabetologia (2006) 1.48
Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM. Diabetes (1996) 1.46
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol (1983) 1.43
Operation of Randle's cycle in patients with NIDDM. Diabetes (1990) 1.40
Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes. Diabetologia (2011) 1.38
Effect of insulin on renal sodium and uric acid handling in essential hypertension. Am J Hypertens (1996) 1.38
Regulation of hepatic glucose metabolism in humans. Diabetes Metab Rev (1987) 1.37
Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance. J Clin Endocrinol Metab (1999) 1.37
Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study. J Clin Endocrinol Metab (2001) 1.34
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes. J Clin Invest (1993) 1.34
Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Am J Physiol (1980) 1.32
Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency. Diabetes (1999) 1.31
Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes (1994) 1.29
Non-steady state: error analysis of Steele's model and developments for glucose kinetics. Am J Physiol (1987) 1.28
Clustering of cardiovascular risk factors in confirmed prehypertensive individuals. Hypertension (1992) 1.27
Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients. Diabetes (2001) 1.24
Insulin resistance in diabetic ketoacidosis. Diabetes (1982) 1.23
Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss. Circulation (2001) 1.23
Blood pressure, retinopathy and urinary albumin excretion in IDDM: the EURODIAB IDDM Complications Study. Diabetologia (1995) 1.22
Effects of insulin on hemodynamics and metabolism in human forearm. Diabetes (1990) 1.20
Time dependence of the interaction between lipid and glucose in humans. Am J Physiol (1989) 1.19
Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-finding study. Diabetes Obes Metab (2012) 1.16
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Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography. Prog Cardiovasc Dis (1989) 1.13
Glucose transport in human skeletal muscle. The in vivo response to insulin. Diabetes (1993) 1.12
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues. J Med Chem (1987) 1.10
Activin A stimulates insulin secretion in cultured human pancreatic islets. J Endocrinol Invest (2000) 1.10
Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease. A study with positron emission tomography. J Clin Invest (1996) 1.10
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Insulin resistance and hyperinsulinemia: No independent relation to left ventricular mass in humans. Circulation (2000) 1.07
Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function. Diabetologia (2006) 1.06
Insulin action and substrate competition. Baillieres Clin Endocrinol Metab (1993) 1.05
Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis. Diabetes (1988) 1.05
Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type II diabetes. Clin Pharmacol Ther (2007) 1.05
Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea. Horm Metab Res (2006) 1.05
The kinetics of insulin in man. II. Role of the liver. Diabetes Metab Rev (1987) 1.04
Coagulation and fibrinolytic system impairment in insulin dependent diabetes mellitus. Thromb Res (1992) 1.04
Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans. Diabetes (1999) 1.04
Pattern of insulin delivery after intravenous glucose injection in man and its relation to plasma glucose disappearance. J Clin Invest (1979) 1.03
Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles. Diabetologia (2008) 1.02
Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss. Int J Obes (Lond) (2009) 1.02
Beta-cell function assessment from modelling of oral tests: an effective approach. Diabetes Obes Metab (2008) 1.01
The islet in type 2 diabetes: back to center stage. Diabetes (2001) 1.01
Evidence for an association of high blood pressure and hyperinsulinemia in obese man. J Clin Endocrinol Metab (1986) 1.01
Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines. J Clin Endocrinol Metab (2001) 1.00
CXCL10 (alpha) and CCL2 (beta) chemokines in systemic sclerosis--a longitudinal study. Rheumatology (Oxford) (2008) 1.00
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Effect of insulin on acetylcholine-induced vasodilation in normotensive subjects and patients with essential hypertension. Circulation (1995) 1.00
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The kinetics of insulin in man. I. General aspects. Diabetes Metab Rev (1987) 0.99
The metabolic effects of cyclosporin and tacrolimus. J Endocrinol Invest (2001) 0.99
Insulin prolongs the QTc interval in humans. Am J Physiol Regul Integr Comp Physiol (2000) 0.99
Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects. Int J Obes (Lond) (2006) 0.99
Uraemia-like syndrome in dogs chronically intoxicated with methylguanidine and creatinine. Clin Sci (1969) 0.98
A model for glucose control of insulin secretion during 24 h of free living. Diabetes (2001) 0.98
Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods. Metabolism (1994) 0.98