Biochemical measurements in Alzheimer's disease reveal a necessity for improved neuroimaging techniques to study metabolism.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 1148998)

Published in Biochem J on April 01, 1988

Authors

A Najlerahim1, D M Bowen

Author Affiliations

1: Miriam Marks Department of Neurochemistry, University of London, U.K.

Articles cited by this

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem (1975) 4.29

Globoid cell leucodystrophy (Krabbe's disease): deficiency of galactocerebroside beta-galactosidase. Proc Natl Acad Sci U S A (1970) 2.48

FABRY'S DISEASE: CLASSIFICATION AS A SPHINGOLIPIDOSIS AND PARTIAL CHARACTERIZATION OF A NOVEL GLYCOLIPID. J Biol Chem (1963) 2.24

Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain (1981) 2.08

Accelerated ageing or selective neuronal loss as an important cause of dementia? Lancet (1979) 1.72

[The tropical localization and content of noradrenalin and dopamine (3-hydroxytyramine) in the substantia nigra of normal persons and patients with Parkinson's disease]. Wien Klin Wochenschr (1963) 1.71

A quantitative study of cerebral atrophy in old age and senile dementia. J Neurol Sci (1981) 1.41

Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease. Brain Res (1987) 1.15

Selective vulnerability of neurones in organic dementia. Nature (1977) 1.14

Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease. Neurology (1986) 1.12

Mitochondrial function in brain tissue in primary degenerative dementia. Brain Res (1987) 1.00

[14C]acetylcholine synthesis and [14C]carbon dioxide production from [U-14C]glucose by tissue prisms from human neocortex. Biochem J (1981) 0.97

Alzheimer's disease: low cerebral somatostatin levels correlate with impaired cognitive function and cortical metabolism. Neurology (1987) 0.92

Positron emission tomography in aging and dementia: effect of cerebral atrophy. J Nucl Med (1987) 0.90

Effects of the GABA receptor agonist, progabide, upon local cerebral glucose utilization. Brain Res (1987) 0.80

Articles by these authors

(truncated to the top 100)

Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain (1976) 2.76

Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J Neurol Sci (1982) 2.17

Neuropsychological syndromes in presenile dementia due to cerebral atrophy. J Neurol Neurosurg Psychiatry (1986) 1.83

Accelerated ageing or selective neuronal loss as an important cause of dementia? Lancet (1979) 1.72

Neocortical cholinergic neurons in elderly people. Lancet (1977) 1.68

Alzheimer's disease: a correlative study. J Neurol Neurosurg Psychiatry (1986) 1.36

Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease. J Neurochem (1983) 1.28

Presynaptic cholinergic dysfunction in patients with dementia. J Neurochem (1983) 1.28

The nucleus basalis in Alzheimer's disease: cell counts and cortical biochemistry. Neuropathol Appl Neurobiol (1983) 1.24

Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients. J Neurol Sci (1982) 1.21

Cerebroside galactosidase: a method for determination and a comparison with other lysosomal enzymes in developing rat brain. J Neurochem (1969) 1.18

Brain-decarboxylase activities as indices of pathological change in senile dementia. Lancet (1974) 1.16

Properties of cerebroside galactosidase. Biochim Biophys Acta (1968) 1.15

Selective vulnerability of neurones in organic dementia. Nature (1977) 1.14

Presynaptic serotonergic dysfunction in patients with Alzheimer's disease. J Neurochem (1987) 1.09

Cerebroside galactosidase of brain. J Lipid Res (1966) 1.07

Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives. J Neurochem (1993) 1.04

Terminal coma affects messenger RNA detection in post mortem human temporal cortex. Brain Res Mol Brain Res (1991) 1.03

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease. Neurosci Lett (1986) 1.02

The modulation by chlormethiazole of the GABAA-receptor complex in rat brain. Br J Pharmacol (1989) 1.01

Biochemical indices of brain structure, function and "hypoxia" in cortex from baboons with middle cerebral artery occlusion. Brain Res (1976) 1.00

Mitochondrial function in brain tissue in primary degenerative dementia. Brain Res (1987) 1.00

Neurochemical studies of early-onset Alzheimer's disease. Possible influence on treatment. N Engl J Med (1985) 1.00

Molecular changes in senile dementia. Brain (1973) 0.98

Chemical pathology of organic dementias. I. Validity of biochemical measurements on human post-mortem brain specimens. Brain (1977) 0.98

Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease. J Neurochem (1988) 0.97

[14C]acetylcholine synthesis and [14C]carbon dioxide production from [U-14C]glucose by tissue prisms from human neocortex. Biochem J (1981) 0.97

Glucose metabolism and acetylcholine synthesis in relation to neuronal activity in Alzheimer's disease. Lancet (1980) 0.96

Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem. Brain Res (1989) 0.96

A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease. J Neurol Neurosurg Psychiatry (1990) 0.96

Possible neurotransmitter basis of behavioral changes in Alzheimer's disease. Ann Neurol (1988) 0.96

Chemical pathology of this organic dementias. II. Quantitative estimation of cellular changes in post-mortem brains. Brain (1977) 0.95

Purification of cerebroside galactosidase from rat brain. Biochim Biophys Acta (1968) 0.95

Alzheimer's disease as a disorder of isodendritic core. Lancet (1982) 0.94

Vitamin E concentrations in human brain of patients with Alzheimer's disease, fetuses with Down's syndrome, centenarians, and controls. Neurochem Res (1989) 0.93

Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. J Neurochem (1996) 0.93

Are post-mortem biochemical studies of human brain worthwhile? Biochem Soc Trans (1988) 0.92

The effects of Alzheimer's disease, other dementias, and premortem course on beta-amyloid precursor protein messenger RNA in frontal cortex. J Neurochem (1994) 0.90

Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease. Brain Res (1987) 0.90

Regional weight loss of the cerebral cortex and some subcortical nuclei in senile dementia of the Alzheimer type. Acta Neuropathol (1988) 0.90

Biochemical studies on degenerative neurological disorders. I. Acute experimental encephalitis. J Neurochem (1974) 0.89

Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. J Neurol Neurosurg Psychiatry (1984) 0.89

The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells. J Neural Transm (Vienna) (1998) 0.88

The evoked release of endogenous amino acids from tissue prisms of human neocortex. Brain Res (1983) 0.88

5-Hydroxytryptamine1A but not 5-hydroxytryptamine2 receptors are enriched on neocortical pyramidal neurones destroyed by intrastriatal volkensin. J Pharmacol Exp Ther (1992) 0.88

Increased transmitter amino acid concentration in human ventricular CSF after brain trauma. Neuroreport (1994) 0.87

Gamma-aminobutyric acid concentration in brain tissue at two stages of Alzheimer's disease. Brain (1988) 0.87

D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain. Brain Res (1991) 0.86

Information-seeking practices of dental hygienists. Bull Med Libr Assoc (1995) 0.85

Glutamate/aspartate-releasing neurons in Alzheimer's disease. N Engl J Med (1986) 0.85

Cellular ageing: selective vulnerability of cholinergic neurones in human brain. Monogr Dev Biol (1984) 0.84

Topographical distribution of neurochemical changes in Alzheimer's disease. J Neurol Sci (1988) 0.84

Biochemical studies of nerve cells and energy metabolism in Alzheimer's disease. Br Med Bull (1986) 0.84

Neurotransmitters and second messengers in aging and Alzheimer's disease. Ann N Y Acad Sci (1993) 0.83

The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type. J Neurol Neurosurg Psychiatry (1988) 0.83

Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms. Neurochem Res (1992) 0.83

Animal and drug modelling for Alzheimer synaptic pathology. Prog Neurobiol (1992) 0.83

Reduced glycine stimulation of [3H]MK-801 binding in Alzheimer's disease. J Neurochem (1989) 0.83

Cholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Brain (1987) 0.83

Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease. Neuroscience (1990) 0.83

Cholinomimetics increase glutamate outflow via an action on the corticostriatal pathway: implications for Alzheimer's disease. J Neurochem (1995) 0.82

The effects of middle-cerebral-artery occlusion on neurotransmitter metabolism in baboons. Biochem Soc Trans (1977) 0.82

Biochemical and ultrastructural studies on subacute sclerosing panencephalitis and demyelination. J Neurol Sci (1974) 0.82

Effect of psychotropic drugs on excitatory amino acids in patients undergoing psychosurgery for depression. Br J Psychiatry (1992) 0.81

Characterisation of the glycine modulatory site of the N-methyl-D-aspartate receptor-ionophore complex in human brain. J Neurochem (1991) 0.81

Cathepsin A in human brain and spleen. Biochem J (1973) 0.81

Destruction of a sub-population of cortical neurones by suicide transport of volkensin, a lectin from Adenia volkensii. J Neurosci Methods (1991) 0.81

Age-related alteration in excitatory amino acid neurotransmission in rat brain. Neurobiol Aging (1990) 0.81

Hydroxy fatty acid metabolism in brain. Adv Lipid Res (1968) 0.81

Extracellular concentrations of aspartate and glutamate in rat neostriatum following chemical stimulation of frontal cortex. Exp Brain Res (1989) 0.81

Treatment strategies for Alzheimer's disease. Lancet (1992) 0.81

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease. Brain Res (1983) 0.81

A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. Biochem J (1995) 0.80

Somatostatin content and release measured in cerebral biopsies from demented patients. J Neurol Sci (1987) 0.80

Soluble beta-amyloid precursor protein and pyramidal neuron loss. Lancet (1993) 0.80

Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias. Brain Res (1994) 0.80

Catecholaminergic neurones assessed ante-mortem in Alzheimer's disease. Brain Res (1987) 0.80

Factors affecting the beta-amyloid precursor in PC12 cells. Biochem Soc Trans (1993) 0.79

Antemortem measurements of neurotransmission: possible implications for pharmacotherapy of Alzheimer's disease and depression. J Neurol Neurosurg Psychiatry (1993) 0.79

Preliminary neurochemical findings in non-Alzheimer dementia due to lobar atrophy. Dementia (1993) 0.79

Binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and Alzheimer brain. J Neurochem (1986) 0.79

Loss of glycine-dependent radioligand binding to the N-methyl-D-aspartate-phencyclidine receptor complex in patients with Alzheimer's disease. Neurosci Lett (1989) 0.79

Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. J Neurol Neurosurg Psychiatry (1985) 0.79

Production of [14C]acetylcholine and [14C]carbon dioxide from [U-14C]glucose in tissue prisms from aging rat brain. J Neurochem (1982) 0.79

Influence of tetrahydro-9-aminoacridine on excitatory amino acid release. Clin Neuropharmacol (1990) 0.79

Localisation of muscarinic (m1) and other neurotransmitter receptors on corticofugal-projecting pyramidal neurones. Brain Res (1993) 0.78

Acetylcholine synthesis and glucose oxidation are preserved in human brain obtained shortly after death. Neurosci Lett (1982) 0.78

Biochemical changes in the cholinergic system of the ageing brain and in senile dementia. Psychol Med (1980) 0.78

Changes in cortical nicotinic acetylcholine receptor numbers following unilateral destruction of pyramidal neurones by intrastriatal volkensin injection. Neurodegeneration (1995) 0.78

Dental hygienists' information seeking and computer application behavior. J Dent Educ (1995) 0.78

Hydrolase activities in brain of neurological mutants: cerebroside galactosidase, nitrophenyl galactoside hydrolase, nitrophenyl glucoside hydrolase and sulphatase. J Neurochem (1969) 0.78

Alzheimer's disease: distribution of protein on sucrose density gradient centrifugation. Acta Neuropathol (1978) 0.78

Letter: Extrapyramidal diseases and dementia. Lancet (1975) 0.78

The dementia of Alzheimer's disease: an update. J Neurol Neurosurg Psychiatry (1987) 0.77

Treatment of Alzheimer's disease: a cautionary note. N Engl J Med (1981) 0.77

The failing brain. J Chronic Dis (1983) 0.77

Neurotransmission--the link integrating Alzheimer research? Trends Neurosci (1994) 0.77

NMDA receptors assessed by autoradiography with [3H]L-689,560 are present but not enriched on corticofugal-projecting pyramidal neurones. Brain Res (1992) 0.77

A comparison of [3H]MK-801 and N-[1-(2-thienyl)cyclohexyl]-3,4-[3H]piperidine binding to the N-methyl-D-aspartate receptor complex in human brain. J Neurochem (1991) 0.77

Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain. J Neurochem (1983) 0.77