Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region.

PubWeight™: 8.81‹?› | Rank: Top 0.1%

🔗 View Article (PMC 254146)

Published in J Virol on May 01, 1987

Authors

M A Bender, T D Palmer, R E Gelinas, A D Miller

Articles citing this

(truncated to the top 100)

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res (1990) 20.53

Improved retroviral vectors for gene transfer and expression. Biotechniques (1989) 19.48

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci U S A (1988) 9.35

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci U S A (1989) 7.19

A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res (1995) 7.08

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol (1996) 6.62

Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence. Proc Natl Acad Sci U S A (1988) 6.44

Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J Virol (1991) 6.19

Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions. J Virol (1989) 6.11

Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J Virol (1990) 5.45

Identification of a signal in a murine retrovirus that is sufficient for packaging of nonretroviral RNA into virions. J Virol (1988) 4.88

Identification of the primary site of the human immunodeficiency virus type 1 RNA dimerization in vitro. Proc Natl Acad Sci U S A (1994) 4.07

The human immunodeficiency virus type 1 encapsidation site is a multipartite RNA element composed of functional hairpin structures. J Virol (1996) 3.91

Virus maturation by budding. Microbiol Mol Biol Rev (1998) 3.78

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells. J Cell Biol (1992) 3.57

RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1. J Virol (1995) 3.53

The human immunodeficiency virus type 1 packaging signal and major splice donor region have a conserved stable secondary structure. J Virol (1992) 3.48

A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology. J Virol (1990) 3.33

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J (1991) 3.23

Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays. J Virol (1993) 3.15

Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein. J Virol (1991) 3.00

Point mutations in the proximal Cys-His box of Rous sarcoma virus nucleocapsid protein. J Virol (1990) 2.93

Human immunodeficiency virus vectors for inducible expression of foreign genes. J Virol (1992) 2.70

Construction and analysis of deletion mutations in the U5 region of Moloney murine leukemia virus: effects on RNA packaging and reverse transcription. J Virol (1989) 2.69

Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA. J Virol (1994) 2.68

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells. Proc Natl Acad Sci U S A (1995) 2.68

cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA. J Virol (1991) 2.66

Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo. J Virol (1988) 2.55

Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions. J Virol (1991) 2.55

Avian retroviral RNA encapsidation: reexamination of functional 5' RNA sequences and the role of nucleocapsid Cys-His motifs. J Virol (1993) 2.52

Tunicamycin treatment of CHO cells abrogates multiple blocks to retrovirus infection, one of which is due to a secreted inhibitor. J Virol (1992) 2.45

Design of vectors for efficient expression of human purine nucleoside phosphorylase in skin fibroblasts from enzyme-deficient humans. Proc Natl Acad Sci U S A (1988) 2.41

Retrovirus packaging cells based on 10A1 murine leukemia virus for production of vectors that use multiple receptors for cell entry. J Virol (1996) 2.36

Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. Mol Cell Biol (1991) 2.36

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc Natl Acad Sci U S A (1991) 2.34

A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis. J Virol (1996) 2.33

Detection of receptor-specific murine leukemia virus binding to cells by immunofluorescence analysis. J Virol (1992) 2.25

Specificity of retroviral RNA packaging. J Virol (1991) 2.22

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc Natl Acad Sci U S A (1989) 2.20

Analysis in human immunodeficiency virus type 1 vectors of cis-acting sequences that affect gene transfer into human lymphocytes. J Virol (1994) 2.18

Simian immunodeficiency virus RNA is efficiently encapsidated by human immunodeficiency virus type 1 particles. J Virol (1993) 2.17

Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region. J Virol (1993) 2.15

Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector. J Virol (1991) 2.15

Analysis of the functional and host range-determining regions of the murine ectropic and amphotropic retrovirus envelope proteins. J Virol (1993) 2.12

Design of retrovirus vectors for transfer and expression of the human beta-globin gene. J Virol (1988) 2.06

Overcoming interference to retroviral superinfection results in amplified expression and transmission of cloned genes. Proc Natl Acad Sci U S A (1988) 2.02

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol (1990) 1.90

Expression cloning of oncogenes by retroviral transfer of cDNA libraries. Mol Cell Biol (1995) 1.89

An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences. J Virol (1994) 1.81

An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors. J Virol (1995) 1.80

Identification of cellular promoters by using a retrovirus promoter trap. J Virol (1989) 1.79

Casein kinase II is a predominantly nuclear enzyme. J Cell Biol (1992) 1.76

Promoter interactions in retrovirus vectors introduced into fibroblasts and embryonic stem cells. J Virol (1991) 1.72

Efficiency and selectivity of RNA packaging by Rous sarcoma virus Gag deletion mutants. J Virol (1994) 1.70

Uncoupled expression of Moloney murine leukemia virus envelope polypeptides SU and TM: a functional analysis of the role of TM domains in viral entry. J Virol (1994) 1.69

A system for studying the selective encapsidation of hepadnavirus RNA. J Virol (1989) 1.69

Development of avian sarcoma and leukosis virus-based vector-packaging cell lines. J Virol (1988) 1.62

Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? Retrovirology (2004) 1.59

A double hairpin structure is necessary for the efficient encapsidation of spleen necrosis virus retroviral RNA. EMBO J (1994) 1.58

Cooperation of an RNA packaging signal and a viral envelope protein in coronavirus RNA packaging. J Virol (2001) 1.56

Novel retroviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res (2002) 1.51

Inhibitors of retrovirus infection are secreted by several hamster cell lines and are also present in hamster sera. J Virol (1993) 1.49

Design of 5' untranslated sequences in retroviral vectors developed for medical use. J Virol (1999) 1.48

Gene targeting with retroviral vectors: recombination by gene conversion into regions of nonhomology. Mol Cell Biol (1989) 1.48

Expression of the human beta-globin gene after retroviral transfer into murine erythroleukemia cells and human BFU-E cells. Mol Cell Biol (1988) 1.45

Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons. J Virol (1999) 1.43

Bovine leukemia virus RNA sequences involved in dimerization and specific gag protein binding: close relation to the packaging sites of avian, murine, and human retroviruses. J Virol (1993) 1.43

Retrovirus vectors containing an internal attachment site: evidence that circles are not intermediates to murine retrovirus integration. J Virol (1989) 1.42

A majority of mice show long-term expression of a human beta-globin gene after retrovirus transfer into hematopoietic stem cells. Mol Cell Biol (1989) 1.41

Expression of human adenosine deaminase in murine hematopoietic cells. Mol Cell Biol (1988) 1.35

cis-active structural motifs involved in specific encapsidation of Moloney murine leukemia virus RNA. J Virol (1996) 1.35

Neurons and glia arise from a common progenitor in chicken optic tectum: demonstration with two retroviruses and cell type-specific antibodies. Proc Natl Acad Sci U S A (1990) 1.34

A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector. Mol Cell Biol (1994) 1.30

Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs. Proc Natl Acad Sci U S A (1990) 1.28

Long-term biological response of injured rat carotid artery seeded with smooth muscle cells expressing retrovirally introduced human genes. J Clin Invest (1994) 1.22

Identification of a sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus. J Virol (1994) 1.21

Defective retroviruses can disperse in the human genome by intracellular transposition. J Virol (1991) 1.19

A murine leukemia virus (MuLV) long terminal repeat derived from rhesus macaques in the context of a lentivirus vector and MuLV gag sequence results in high-level gene expression in human T lymphocytes. J Virol (2000) 1.19

Mapping the encapsidation determinants of feline immunodeficiency virus. J Virol (2002) 1.18

Phosphorylation sites in the amino-terminal region of mouse p53. Proc Natl Acad Sci U S A (1992) 1.18

The leading sequence of caulimovirus large RNA can be folded into a large stem-loop structure. Nucleic Acids Res (1988) 1.18

trans-acting proteins involved in RNA encapsidation and viral assembly in human immunodeficiency virus type 1. J Virol (1996) 1.17

Production of high-titer helper virus-free retroviral vectors by cocultivation of packaging cells with different host ranges. J Virol (1991) 1.17

Sequences in pol are required for transfer of human foamy virus-based vectors. J Virol (1998) 1.15

The bovine leukemia virus encapsidation signal is discontinuous and extends into the 5' end of the gag gene. J Virol (1995) 1.11

Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors. J Virol (1998) 1.10

Transduction of cellular neo mRNA by retrovirus-mediated recombination. J Virol (1990) 1.08

Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration. J Virol (1999) 1.07

Genetic induction of immune tolerance to human clotting factor VIII in a mouse model for hemophilia A. Proc Natl Acad Sci U S A (1998) 1.07

An Mpsi-containing heterologous RNA, but not env mRNA, is efficiently packaged into avian retroviral particles. J Virol (1999) 1.07

cis-Acting sequences required for simian foamy virus type 1 vectors. J Virol (1998) 1.04

RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells. Mol Cancer (2004) 1.04

Strand breaks without DNA rearrangement in V (D)J recombination. Mol Cell Biol (1991) 1.04

Transduction of primary human hepatocytes with amphotropic and xenotropic retroviral vectors. Proc Natl Acad Sci U S A (1992) 1.04

The LTR, v-src, LTR provirus generated in the mammalian genome by src mRNA reverse transcription and integration. J Virol (1989) 1.03

Anchoring and degradation of glycolipid-anchored membrane proteins by L929 versus by LM-TK- mouse fibroblasts: implications for anchor biosynthesis. Mol Cell Biol (1991) 1.02

An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors. J Virol (1995) 1.00

Resistance to human immunodeficiency virus type 1 infection conferred by transduction of human peripheral blood lymphocytes with ribozyme, antisense, or polymeric trans-activation response element constructs. Proc Natl Acad Sci U S A (1995) 1.00

High-frequency intracellular transposition of a defective mammalian provirus detected by an in situ colorimetric assay. J Virol (1992) 1.00

Expression of active human immunodeficiency virus type 1 protease by noninfectious chimeric virus particles. J Virol (1991) 1.00

Articles cited by this

DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54

A system for shotgun DNA sequencing. Nucleic Acids Res (1981) 52.99

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46

Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol (1986) 16.65

A new dominant hybrid selective marker for higher eukaryotic cells. J Mol Biol (1981) 9.51

Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae. Gene (1983) 8.79

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature (1985) 7.54

Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene. Mol Cell Biol (1985) 7.49

Factors involved in production of helper virus-free retrovirus vectors. Somat Cell Mol Genet (1986) 6.48

Effect of internal viral sequences on the utility of retroviral vectors. J Virol (1987) 6.06

Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene. Proc Natl Acad Sci U S A (1982) 5.56

Varying the position of a retrovirus packaging sequence results in the encapsidation of both unspliced and spliced RNAs. J Virol (1985) 5.21

Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors. Mol Cell Biol (1983) 4.96

Gene expression in mice after high efficiency retroviral-mediated gene transfer. Science (1985) 4.77

Avian oncovirus mutant (SE21Q1b) deficient in genomic RNA: characterization of a deletion in the provirus. J Virol (1980) 4.77

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1. J Virol (1981) 4.54

Amphotropic retrovirus vector system for human cell gene transfer. Mol Cell Biol (1984) 4.16

Identification of a sequence likely to be required for avian retroviral packaging. Virology (1983) 3.33

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT. Proc Natl Acad Sci U S A (1983) 3.31

Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Nature (1986) 3.30

Deletion mutants of Moloney murine leukemia virus which lack glycosylated gag protein are replication competent. J Virol (1983) 3.04

Characterization of a Rous sarcoma virus mutant defective in packaging its own genomic RNA: biochemical properties of mutant TK15 and mutant-induced transformants. J Virol (1984) 2.95

Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human. Proc Natl Acad Sci U S A (1987) 2.72

gag-Related polyproteins of Moloney murine leukemia virus: evidence for independent synthesis of glycosylated and unglycosylated forms. J Virol (1979) 2.68

Rous sarcoma virus encodes a transcriptional activator. Cell (1985) 2.28

Retroviral transfer of genes into canine hemopoietic progenitor cells in culture: a model for human gene therapy. Proc Natl Acad Sci U S A (1986) 2.14

Sequence relationship of glycosylated and unglycosylated gag polyproteins of Moloney murine leukemia virus. J Virol (1980) 1.83

Murine leukemia virus gag polyproteins: the peptide chain unique to Pr80 is located at the amino terminus. Virology (1978) 1.73

Homology among oncogenes. Curr Top Microbiol Immunol (1986) 1.19

Articles by these authors

Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol (1986) 16.65

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell (1977) 9.44

Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene. Mol Cell Biol (1985) 7.49

An expansive human regulatory lexicon encoded in transcription factor footprints. Nature (2012) 7.27

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci U S A (1989) 7.19

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature (1991) 6.79

Factors involved in production of helper virus-free retrovirus vectors. Somat Cell Mol Genet (1986) 6.48

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol (1990) 5.81

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell (2005) 5.77

Nucleotide sequences from the adenovirus-2 genome. J Biol Chem (1982) 5.76

c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell (1984) 5.55

Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18

Viral and cellular fos proteins: a comparative analysis. Cell (1984) 4.89

Identification of a signal in a murine retrovirus that is sufficient for packaging of nonretroviral RNA into virions. J Virol (1988) 4.88

Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Proc Natl Acad Sci U S A (1994) 4.67

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A (1994) 4.07

Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03

The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation. Genes Dev (2006) 3.91

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc Natl Acad Sci U S A (1995) 3.89

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years. Science (1995) 3.87

Two sequence-specific endonucleases from Moraxella bovis. J Mol Biol (1977) 3.65

Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49

Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci (2000) 3.40

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT. Proc Natl Acad Sci U S A (1983) 3.31

Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Nature (1986) 3.30

One predominant 5'-undecanucleotide in adenovirus 2 late messenger RNAs. Cell (1977) 3.30

Retroviral RNA packaging: sequence requirements and implications. Curr Top Microbiol Immunol (1990) 3.22

Multipotent progenitor cells in the adult dentate gyrus. J Neurobiol (1998) 3.15

A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction. Proc Natl Acad Sci U S A (1999) 3.13

A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol (2003) 3.09

Two base changes restore infectivity to a noninfectious molecular clone of Moloney murine leukemia virus (pMLV-1). J Virol (1984) 3.09

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. Proc Natl Acad Sci U S A (1985) 2.95

Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors. J Virol (2001) 2.95

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A (2001) 2.94

DNA and chromatin structure of the human alpha 1 (I) collagen gene. J Biol Chem (1984) 2.85

Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human. Proc Natl Acad Sci U S A (1987) 2.72

Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc Natl Acad Sci U S A (1991) 2.67

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration. J Virol (1997) 2.65

The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev (2003) 2.65

Universal primers for fluorescent labelling of PCR fragments--an efficient and cost-effective approach to genotyping by fluorescence. Mol Ecol Resour (2012) 2.63

Adeno-associated virus vectors preferentially transduce cells in S phase. Proc Natl Acad Sci U S A (1994) 2.62

Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines. Blood (1989) 2.56

A family of retroviruses that utilize related phosphate transporters for cell entry. J Virol (1994) 2.55

Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions. J Virol (1991) 2.55

Production of human factor IX in animals by genetically modified skin fibroblasts: potential therapy for hemophilia B. Blood (1989) 2.53

DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors. J Virol (1994) 2.50

Expression of a retrovirus encoding human HPRT in mice. Science (1984) 2.48

Tunicamycin treatment of CHO cells abrogates multiple blocks to retrovirus infection, one of which is due to a secreted inhibitor. J Virol (1992) 2.45

Altered triple helical structure of type I procollagen in lethal perinatal osteogenesis imperfecta. J Biol Chem (1985) 2.45

Design of vectors for efficient expression of human purine nucleoside phosphorylase in skin fibroblasts from enzyme-deficient humans. Proc Natl Acad Sci U S A (1988) 2.41

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39

Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes. J Virol (2000) 2.26

A functional element necessary for fetal hemoglobin silencing. N Engl J Med (2011) 2.25

Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. Proc Natl Acad Sci U S A (1997) 2.22

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol Cell (1998) 2.22

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc Natl Acad Sci U S A (1995) 2.20

Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol (1996) 2.17

The human growth hormone locus: nucleotide sequence, biology, and evolution. Genomics (1989) 2.17

Retroviral transfer of genes into canine hemopoietic progenitor cells in culture: a model for human gene therapy. Proc Natl Acad Sci U S A (1986) 2.14

Successful readministration of adeno-associated virus vectors to the mouse lung requires transient immunosuppression during the initial exposure. J Virol (1998) 2.11

Design of retrovirus vectors for transfer and expression of the human beta-globin gene. J Virol (1988) 2.06

Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins. Microbiol Mol Biol Rev (2001) 2.06

Regulatory elements in the first intron contribute to transcriptional control of the human alpha 1(I) collagen gene. Proc Natl Acad Sci U S A (1987) 1.96

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol (1990) 1.90

The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. Proc Natl Acad Sci U S A (1999) 1.88

Retrovirus vectors bearing jaagsiekte sheep retrovirus Env transduce human cells by using a new receptor localized to chromosome 3p21.3. J Virol (2000) 1.88

The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids Res (1983) 1.81

Infectious and selectable retrovirus containing an inducible rat growth hormone minigene. Science (1984) 1.80

Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol (1999) 1.79

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4. J Virol (1993) 1.74

Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Proc Natl Acad Sci U S A (2000) 1.74

An RGD-oligolysine peptide: a prototype construct for integrin-mediated gene delivery. Hum Gene Ther (1998) 1.73

Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development (1999) 1.73

Human purine nucleoside phosphorylase and adenosine deaminase: gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses. Mol Cell Biol (1987) 1.73

Foamy virus vectors. J Virol (1996) 1.72

18 F-fluoride for bone imaging. Semin Nucl Med (1972) 1.69

Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Proc Natl Acad Sci U S A (1999) 1.68

Lethal osteogenesis imperfecta resulting from a single nucleotide change in one human pro alpha 1(I) collagen allele. Proc Natl Acad Sci U S A (1986) 1.65

Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci (1998) 1.62

Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors. Hum Gene Ther (1996) 1.60

Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells. J Virol (1995) 1.58

The eggshell of insects: differentiation-specific proteins and the control of their synthesis and accumulation during development. Results Probl Cell Differ (1977) 1.56

Improved adeno-associated virus vector production with transfection of a single helper adenovirus gene, E4orf6. Mol Ther (2000) 1.55

Intron-mediated recombination may cause a deletion in an alpha 1 type I collagen chain in a lethal form of osteogenesis imperfecta. Proc Natl Acad Sci U S A (1985) 1.53

Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation. Mol Psychiatry (2007) 1.52

Inhibitors of retrovirus infection are secreted by several hamster cell lines and are also present in hamster sera. J Virol (1993) 1.49

Blood culture cross contamination associated with a radiometric analyzer. J Clin Microbiol (1982) 1.48

The crystal structure of the lysyl-tRNA synthetase (LysU) from Escherichia coli. Structure (1995) 1.48

Effects of immediate and delayed error correction on the acquisition and maintenance of sight words by students with developmental disabilities. J Appl Behav Anal (1994) 1.47

Epizootic myocarditis associated with encephalomyocarditis virus in a group of rhesus macaques (Macaca mulatta). Vet Pathol (2011) 1.46

Expression of the human beta-globin gene after retroviral transfer into murine erythroleukemia cells and human BFU-E cells. Mol Cell Biol (1988) 1.45

A specific endonuclease from Brevibacterium albidum. J Mol Biol (1977) 1.43

The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible species. J Virol (1995) 1.43

Efficient insertion of genes into the mouse germ line via retroviral vectors. Proc Natl Acad Sci U S A (1985) 1.42

Uniformity of radiation-induced mutation rates among different species. Nature (1973) 1.42

A majority of mice show long-term expression of a human beta-globin gene after retrovirus transfer into hematopoietic stem cells. Mol Cell Biol (1989) 1.41