Published in Ann N Y Acad Sci on January 01, 1986
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J Biol Chem (1980) 6.80
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature (2001) 6.70
Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. N Engl J Med (1999) 5.05
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol (2000) 4.64
Exercise, glucose transport, and insulin sensitivity. Annu Rev Med (1998) 4.00
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med (2000) 3.53
Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity. J Biol Chem (1981) 3.28
Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients. J Clin Invest (1973) 3.21
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest (1995) 3.18
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem (1993) 3.02
Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions. Biochim Biophys Acta (1983) 2.88
Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. J Biol Chem (1990) 2.84
Hormonal regulation of mammalian glucose transport. Annu Rev Biochem (1986) 2.84
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest (2000) 2.75
Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia (2007) 2.71
Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action. J Biol Chem (1993) 2.41
Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem (1995) 2.27
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest (1999) 2.22
Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol (1993) 2.06
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J Clin Invest (2001) 2.01
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest (1999) 2.00
Mechanism of insulin action on glucose transport in the isolated rat adipose cell. Enhancement of the number of functional transport systems. J Biol Chem (1978) 1.99
Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes (1990) 1.93
Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats. J Clin Invest (1989) 1.89
Analysis of GLUT4 distribution in whole skeletal muscle fibers: identification of distinct storage compartments that are recruited by insulin and muscle contractions. J Cell Biol (1998) 1.83
Glucose deprivation and hexose transporter polypeptides of murine fibroblasts. J Biol Chem (1986) 1.81
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol (1999) 1.79
Inflammation in subcutaneous adipose tissue: relationship to adipose cell size. Diabetologia (2009) 1.70
Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells. J Lipid Res (1978) 1.67
Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools. J Biol Chem (1994) 1.67
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology (2000) 1.66
Structure-function relationships in the adipose cell. I. Ultrastructure of the isolated adipose cell. J Cell Biol (1970) 1.58
Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin. J Cell Sci (2001) 1.57
Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia (2007) 1.57
Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. J Clin Endocrinol Metab (1993) 1.55
Mechanism of insulin-resistant glucose transport activity in the enlarged adipose cell of the aged, obese rat. J Clin Invest (1982) 1.51
Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem (1998) 1.51
Demonstration of insulin-responsive trafficking of GLUT4 and vpTR in fibroblasts. J Cell Sci (2000) 1.48
A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems. J Clin Invest (1981) 1.47
Detection of the rat adipose cell glucose transporter with antibody against the human red cell glucose transporter. Biochem Biophys Res Commun (1982) 1.46
Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol (1997) 1.44
High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes (1997) 1.44
Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes. Horm Metab Res (2007) 1.43
Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents. J Biol Chem (1987) 1.42
Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle. Am J Physiol (1990) 1.40
Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue. Obesity (Silver Spring) (2009) 1.39
Development of an intracellular pool of glucose transporters in 3T3-L1 cells. J Biol Chem (1992) 1.37
Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis. Am J Physiol (1995) 1.37
Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol Cell Biol (1995) 1.36
Divergent molecular mechanisms for insulin-resistant glucose transport in muscle and adipose cells in vivo. J Biol Chem (1990) 1.36
Divergent mechanisms for the insulin resistant and hyperresponsive glucose transport in adipose cells from fasted and refed rats. Alterations in both glucose transporter number and intrinsic activity. J Clin Invest (1988) 1.32
Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter. Endocrinology (1997) 1.32
Insulin-stimulated glucose transport in rat adipose cells. Modulation of transporter intrinsic activity by isoproterenol and adenosine. J Biol Chem (1986) 1.32
Endocytosis of the glucose transporter GLUT4 is mediated by the GTPase dynamin. J Biol Chem (1998) 1.30
Activity and phosphorylation state of glucose transporters in plasma membranes from insulin-, isoproterenol-, and phorbol ester-treated rat adipose cells. J Biol Chem (1987) 1.29
Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A (1994) 1.29
Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem (2001) 1.28
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest (1991) 1.28
Mechanism for markedly hyperresponsive insulin-stimulated glucose transport activity in adipose cells from insulin-treated streptozotocin diabetic rats. Evidence for increased glucose transporter intrinsic activity. J Biol Chem (1987) 1.27
Qualitative and quantitative comparison of glucose transport activity and glucose transporter concentration in plasma membranes from basal and insulin-stimulated rat adipose cells. Biochem J (1988) 1.27
Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. J Biol Chem (1994) 1.26
Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem (1996) 1.24
Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin. J Histochem Cytochem (1997) 1.24
Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension (1992) 1.23
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab (1993) 1.22
Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology (1997) 1.22
Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J (1992) 1.21
Insulin-regulated trafficking of dual-labeled glucose transporter 4 in primary rat adipose cells. Biochem Biophys Res Commun (2001) 1.19
Immunoelectron microscopic evidence that GLUT4 translocation explains the stimulation of glucose transport in isolated rat white adipose cells. J Cell Sci (2000) 1.18
Structure-function relationships in the adipose cell. II. Pinocytosis and factors influencing its activity in the isolated adipose cell. J Cell Biol (1970) 1.14
Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture. Biochem Biophys Res Commun (1993) 1.14
Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem Soc Trans (2003) 1.13
A possible mechanism of insulin resistance in the rat adipose cell with high-fat/low-carbohydrate feeding. Depletion of intracellular glucose transport systems. Diabetes (1982) 1.13
Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women. Diabetologia (2008) 1.12
Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment. Diabetes (1990) 1.12
Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes. J Biol Chem (1997) 1.11
Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes (2000) 1.10
GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure. Diabetes (2001) 1.09
Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein. Biochem J (1996) 1.09
Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells. Biochem J (2001) 1.08
Biochemical and functional heterogeneity of rat adipocyte glucose transporters. J Biol Chem (1986) 1.08
Insulin stimulation of glucose transport activity in rat skeletal muscle: increase in cell surface GLUT4 as assessed by photolabelling. Biochem J (1994) 1.08
Type 2 diabetes--who is conducting the orchestra? Nat Genet (1998) 1.08
Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin-responsive cells. Bioessays (1994) 1.08
Calorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle. Am J Physiol (1998) 1.05
Morphological effects of wortmannin on the endosomal system and GLUT4-containing compartments in rat adipose cells. J Cell Sci (1997) 1.05
Vp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cells. FEBS Lett (1997) 1.04
Insulinomimetic effect on glucose transport by epidermal growth factor when combined with a major histocompatibility complex class I-derived peptide. J Biol Chem (1993) 1.04
Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation. J Biol Chem (2000) 1.04
Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states. Biochem J (1996) 1.04
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc Natl Acad Sci U S A (2001) 1.03
Regulation of glucose utilization in adipose cells and muscle after long-term experimental hyperinsulinemia in rats. J Clin Invest (1985) 1.03
Insulin sensitivity in cystic fibrosis. Diabetes (1994) 1.02
Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes (1996) 1.02
Subcellular translocation of glucose transporters: role in insulin action and its perturbation in altered metabolic states. Diabetes Metab Rev (1985) 1.02