Published in Biometrics on June 01, 1986
Management of osteoarthritis (OA) with an unsupervised home based exercise programme and/or patient administered assessment tools. A cluster randomised controlled trial with a 2x2 factorial design. Ann Rheum Dis (2004) 2.29
Th17/Treg ratio in human graft-versus-host disease. Blood (2010) 1.19
Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patients. Am J Psychiatry (2010) 1.15
Development of gold standard ion-selective electrode-based methods for fluoride analysis. Caries Res (2010) 0.98
Individual consistency in the behaviors of newly-settled reef fish. PeerJ (2015) 0.85
Traumatic brain injury detection using electrophysiological methods. Front Hum Neurosci (2015) 0.82
Intra and inter-examiner reliability of the subacromial impingement index. Skeletal Radiol (2009) 0.76
Efficient Bayesian joint models for group randomized trials with multiple observation times and multiple outcomes. Stat Med (2012) 0.75
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med (1999) 20.31
The impact of patient-centered care on outcomes. J Fam Pract (2000) 15.07
Randomization by cluster. Sample size requirements and analysis. Am J Epidemiol (1981) 9.21
WHO antenatal care randomised trial for the evaluation of a new model of routine antenatal care. Lancet (2001) 6.86
Sample size and optimal designs for reliability studies. Stat Med (1998) 6.80
Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group. N Engl J Med (1995) 6.23
Small sample performance of tests of homogeneity of odds ratios in K 2 x 2 tables. Stat Med (1992) 6.20
Evaluation of a palliative care service: problems and pitfalls. BMJ (1994) 5.70
Users' guides to the medical literature. V. How to use an article about prognosis. Evidence-Based Medicine Working Group. JAMA (1994) 4.49
Developments in cluster randomized trials and Statistics in Medicine. Stat Med (2007) 4.12
Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Crit Care Med (2001) 3.65
Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev (2006) 3.65
Approaches to sample size estimation in the design of clinical trials--a review. Stat Med (1984) 3.28
A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. JAMA (1997) 3.26
Sample size requirements for reliability studies. Stat Med (1987) 3.15
Analysis of data arising from a stratified design with the cluster as unit of randomization. Stat Med (1987) 3.01
Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev (2005) 3.00
Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration. Arthritis Rheum (2000) 2.92
Non-alcoholic duct destructive chronic pancreatitis. Gut (1997) 2.79
Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev (2002) 2.65
Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev (2006) 2.59
ACR and EULAR improvement criteria have comparable validity in rheumatoid arthritis trials. American College of Rheumatology European League of Associations for Rheumatology. J Rheumatol (1999) 2.58
Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people. BMJ (1995) 2.58
Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis (2008) 2.55
Multicentre trial to introduce the Ottawa ankle rules for use of radiography in acute ankle injuries. Multicentre Ankle Rule Study Group. BMJ (1995) 2.50
Laboratory evaluation in the diagnosis of Lyme disease. Ann Intern Med (1997) 2.48
Methods in health service research. Evaluation of health interventions at area and organisation level. BMJ (1999) 2.48
Peripheral nerve function in sepsis and multiple organ failure. Chest (1991) 2.46
Dictated versus database-generated discharge summaries: a randomized clinical trial. CMAJ (1999) 2.28
Contemporary practice patterns in the management of newly diagnosed hypertension. CMAJ (1997) 2.23
Acetaminophen for osteoarthritis. Cochrane Database Syst Rev (2006) 2.21
Warfarin for atrial fibrillation. The patient's perspective. Arch Intern Med (1996) 2.18
Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol (2001) 2.16
The merits of matching in community intervention trials: a cautionary tale. Stat Med (1997) 2.14
The estimation of intraclass correlation in the analysis of family data. Biometrics (1980) 2.06
Randomised trialomania? The multicentre liver transplant trials of tacrolimus. Lancet (1995) 2.04
Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev (2002) 2.01
Adjustments to the Mantel-Haenszel chi-square statistic and odds ratio variance estimator when the data are clustered. Stat Med (1987) 2.00
Preventing perineal trauma during childbirth: a systematic review. Obstet Gynecol (2000) 1.98
Responsiveness of the short form-36, disability of the arm, shoulder, and hand questionnaire, patient-rated wrist evaluation, and physical impairment measurements in evaluating recovery after a distal radius fracture. J Hand Surg Am (2000) 1.98
Tissue adhesive versus suture wound repair at 1 year: randomized clinical trial correlating early, 3-month, and 1-year cosmetic outcome. Ann Emerg Med (1998) 1.93
School feeding for improving the physical and psychosocial health of disadvantaged elementary school children. Cochrane Database Syst Rev (2007) 1.88
Do silicone breast implants cause rheumatologic disorders? A systematic review for a court-appointed national science panel. Arthritis Rheum (2001) 1.88
Do family physicians need medical assistants to detect and manage hypertension? CMAJ (1986) 1.85
Current and future challenges in the design and analysis of cluster randomization trials. Stat Med (2001) 1.80
Nature, time course and dose dependence of zidovudine-related side effects: results from the Multicenter Canadian Azidothymidine Trial. AIDS (1989) 1.78
Hepatotoxicity of erythromycin estolate during pregnancy. Antimicrob Agents Chemother (1977) 1.75
The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation. J Am Coll Surg (1996) 1.71
Construction of confidence limits about effect measures: a general approach. Stat Med (2008) 1.69
Structure and function of neuronal nicotinic acetylcholine receptors. Prog Brain Res (1996) 1.66
Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Arthritis Rheum (2008) 1.66
Looking for important change/differences in studies of responsiveness. OMERACT MCID Working Group. Outcome Measures in Rheumatology. Minimal Clinically Important Difference. J Rheumatol (2001) 1.64
Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) (2000) 1.64
Etanercept for the treatment of rheumatoid arthritis. Cochrane Database Syst Rev (2003) 1.63
Should improvement in rheumatoid arthritis clinical trials be defined as fifty percent or seventy percent improvement in core set measures, rather than twenty percent? Arthritis Rheum (1998) 1.62
Combination treatment of severe rheumatoid arthritis with cyclosporine and methotrexate for forty-eight weeks: an open-label extension study. The Methotrexate-Cyclosporine Combination Study Group. Arthritis Rheum (1997) 1.61
Fluoride for the treatment of postmenopausal osteoporotic fractures: a meta-analysis. Osteoporos Int (2000) 1.59
Plasma lipids and lipoproteins in vegetarians and controls. N Engl J Med (1975) 1.59
A Canadian survey of transfusion practices in critically ill patients. Transfusion Requirements in Critical Care Investigators and the Canadian Critical Care Trials Group. Crit Care Med (1998) 1.58
Matrix metalloproteinases degrade myelin basic protein. Neurosci Lett (1995) 1.54
When should hypertension be treated? The different perspectives of Canadian family physicians and patients. CMAJ (2000) 1.51
Persistence of middle-ear effusion after acute otitis media in children. N Engl J Med (1979) 1.50
Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol (1995) 1.49
The assessment of the economic return from controlled clinical trials. A framework applied to clinical trials of colorectal cancer follow-up. Eur J Health Econ (2003) 1.49
A randomized controlled trial of strict glycemic control and tertiary level obstetric care versus routine obstetric care in the management of gestational diabetes: a pilot study. Am J Obstet Gynecol (1997) 1.49
Clinical spectrum of gonococcal infection in women. Lancet (1977) 1.49
Patient versus injury factors as predictors of pain and disability six months after a distal radius fracture. J Clin Epidemiol (2002) 1.46
A phase I study of chemically synthesized verotoxin (Shiga-like toxin) Pk-trisaccharide receptors attached to chromosorb for preventing hemolytic-uremic syndrome. J Infect Dis (1995) 1.43
Etidronate for treating and preventing postmenopausal osteoporosis. Cochrane Database Syst Rev (2001) 1.42
CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood-brain barrier breakdown. Curr Biol (1998) 1.41
Randomised study of n of 1 trials versus standard practice. BMJ (1996) 1.41
Are ordinal models useful for classification? Stat Med (1991) 1.40
Intensity of exercise for the treatment of osteoarthritis. Cochrane Database Syst Rev (2003) 1.39
Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein. Biochem Biophys Res Commun (1996) 1.38
Function and health-related quality of life: results from a randomized controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group. Arthritis Rheum (1999) 1.38
Transcutaneous electrical nerve stimulation for knee osteoarthritis. Cochrane Database Syst Rev (2000) 1.35
Does transfusion practice affect mortality in critically ill patients? Transfusion Requirements in Critical Care (TRICC) Investigators and the Canadian Critical Care Trials Group. Am J Respir Crit Care Med (1997) 1.34
Acquired immune deficiency syndrome in Canada: the first 5 years of surveillance. CMAJ (1988) 1.34
Analytical subcellular fractionation of jejunal biopsy specimens: enzyme activities, organelle pathology and response to gluten withdrawal in patients with coeliac disease. Clin Sci Mol Med (1978) 1.28
Utilization of prenatal genetic diagnosis in women 35 years of age and older in the United States, 1977 to 1978. Am J Obstet Gynecol (1981) 1.28
A regression approach to the analysis of data arising from cluster randomization. Int J Epidemiol (1985) 1.28
Are therapeutic decisions supported by evidence from health care research? Arch Intern Med (1998) 1.28
Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev (2005) 1.28
An empirical study of cluster randomization. Int J Epidemiol (1982) 1.26
Meta-analyses in systematic reviews of randomized controlled trials in perinatal medicine: comparison of fixed and random effects models. Stat Med (2001) 1.26
Bisphosphonates for steroid induced osteoporosis. Cochrane Database Syst Rev (2000) 1.25
Low level laser therapy (Classes I, II and III) for treating rheumatoid arthritis. Cochrane Database Syst Rev (2005) 1.24
Factors affecting the comparability of meta-analyses and largest trials results in perinatology. J Clin Epidemiol (1997) 1.24
Total and functional antibody response to a quadrivalent meningococcal polysaccharide vaccine among children. J Pediatr (1996) 1.22
Application of the McNemar test to non-independent matched pair data. Stat Med (1991) 1.22
Optimal intravenous dosing strategies for sedatives and analgesics in the intensive care unit. Crit Care Clin (1995) 1.21
Tai chi for treating rheumatoid arthritis. Cochrane Database Syst Rev (2004) 1.20
Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis. J Rheumatol (2000) 1.20
Facilitation of brain stimulation reward by delta 9-tetrahydrocannabinol. Psychopharmacology (Berl) (1988) 1.19
Awareness and use of the Ottawa ankle and knee rules in 5 countries: can publication alone be enough to change practice? Ann Emerg Med (2001) 1.19
Do blood transfusions improve outcomes related to mechanical ventilation? Chest (2001) 1.19
Transcutaneous electrical nerve stimulation (TENS) for the treatment of rheumatoid arthritis in the hand. Cochrane Database Syst Rev (2003) 1.18
Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev (2004) 1.18