Published in Biochem J on March 01, 1985
Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites exhibit the activity and specificity of the respective enzyme. Proc Natl Acad Sci U S A (1993) 0.98
Profile of the alpha-bungarotoxin-binding regions on the extracellular part of the alpha-chain of Torpedo californica acetylcholine receptor. Biochem J (1987) 0.86
Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature (1962) 64.93
A simplified method for cyanogen bromide activation of agarose for affinity chromatography. Anal Biochem (1974) 13.32
Hydrolysis of proteins with p-toluenesulfonic acid. Determination of tryptophan. J Biol Chem (1971) 5.28
Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution. J Mol Biol (1974) 3.17
Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites. Immunochemistry (1978) 3.12
The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0. J Mol Biol (1975) 2.24
Immunochemistry of sperm whale myoglobin. I. The specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen. Biochemistry (1968) 2.17
The precise and entire antigenic structure of native lysozyme. Biochem J (1978) 2.15
Covalent labeling of active sites. Adv Protein Chem (1967) 2.03
A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the alpha-chain of human haemoglobin. Biochem J (1980) 1.62
Immunochemistry of sperm-whale myoglobin. XVI. Accurate delineation of the single region in sequence 1-55 by immunochemical studies of synthetic peptides. Some conclusions concerning antigenic structures of proteins. Immunochemistry (1974) 1.57
The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution. J Mol Biol (1974) 1.55
Immunochemistry of sperm-whale myoglobin. 18. Accurate delineation of the single reactive region in sequence 120-153 by study of synthetic peptides. Biochim Biophys Acta (1973) 1.54
The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution. Cold Spring Harb Symp Quant Biol (1972) 1.45
Use of immunoadsorbents for the study of antibody binding to sperm whale myoglobin and its synthetic antigenic sites. J Immunol Methods (1979) 1.42
Enzymic and immunochemical properties of lysozyme. XVI. A novel synthetic approach to an antigenic reactive site by direct linkage of the relevant conformationally adjacent residues constituting the site. Biochim Biophys Acta (1976) 1.37
Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis. Biochem J (1977) 1.28
Delineation of the third antigenic site of lysozyme by application of a novel 'surface-simulation' synthetic approach directly linking the conformationally adjacent residues forming the site. Biochem J (1976) 1.27
Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites. Mol Cell Biochem (1980) 1.13
The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotyrpsin and trypsin. J Pharmacol Exp Ther (1969) 1.11
Enzymic and immunochemical properties of lysozyme. XIX. Definition of the direction and conformational restrictions of the antigenic site around the disulfide bonds 64-80 and 76-94 (site 2) by 'surface-simulation' synthesis. Biochim Biophys Acta (1977) 1.09
Antibody-combining sites can be mimicked synthetically. Surface-simulation synthesis of the immunoglobulin new combining site to the gamma-hydroxyl derivative of vitamin K1. J Biol Chem (1978) 1.09
Inactivation of bovine trypsinogen and chymotrypsinogen by diisopropylphosphorofluoridate. Proc Natl Acad Sci U S A (1972) 1.03
Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis. Biochem J (1978) 1.01
Immunochemistry of sperm-whale myoglobin. XIX. Accurate delineation of the single reactive region in sequence 54-85 by immunochemical study of synthetic peptides. Biochim Biophys Acta (1974) 0.99
Antibody combining sites can be mimicked synthetically. Surface-simulation synthesis of the phosphorylcholine-combining site of myeloma protein M-603. Biochem J (1980) 0.91
Immune recognition of serum albumin--XIII. Autoreactivity with rabbit serum albumin of rabbit antibodies against bovine or human serum albumins and autoimmune recognition of rabbit serum albumin. Mol Immunol (1981) 0.91
The structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor III. Structure of the anhydro-trypsin-inhibitor complex. Biophys Struct Mech (1975) 0.90
High yield coupling of peptides to protein carriers. Biochim Biophys Acta (1981) 0.90
Can an antibody-combining site be mimicked synthetically? The possible surface simulation synthesis of two antibody-combining sites complementary to two antigenic sites of lysozyme. J Biol Chem (1977) 0.88
T-lymphocyte recognition of sperm-whale myoglobin. Recognition of synthetic peptides carrying antigenic site 5 by myoglobin-primed T-cells. J Immunogenet (1983) 0.85
Determination of the entire antigenic structure of native lysozyme by surface-simulation synthesis, a novel concept in molecular recognition. CRC Crit Rev Biochem (1979) 0.81
Production of monoclonal antibodies with pre-selected submolecular binding specificities to protein determinants: demonstration with sperm whale myoglobin. Mol Immunol (1982) 0.77
Antigenic structure of myoglobin: the complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins. Immunochemistry (1975) 4.90
Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites. Immunochemistry (1978) 3.12
Immunochemistry of sperm whale myoglobin. I. The specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen. Biochemistry (1968) 2.17
The precise and entire antigenic structure of native lysozyme. Biochem J (1978) 2.15
Prediction and conformation by synthesis of two antigenic sites in human haemoglobin by extrapolation from the known antigenic structure of sperm-whale myoglobin. Biochem J (1977) 1.99
A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the alpha-chain of human haemoglobin. Biochem J (1980) 1.62
Immunochemistry of sperm-whale myoglobin. XVI. Accurate delineation of the single region in sequence 1-55 by immunochemical studies of synthetic peptides. Some conclusions concerning antigenic structures of proteins. Immunochemistry (1974) 1.57
Immunochemistry of sperm-whale myoglobin. 18. Accurate delineation of the single reactive region in sequence 120-153 by study of synthetic peptides. Biochim Biophys Acta (1973) 1.54
Use of immunoadsorbents for the study of antibody binding to sperm whale myoglobin and its synthetic antigenic sites. J Immunol Methods (1979) 1.42
A proposal for the nomenclature of antigenic sites in peptides and proteins. Immunochemistry (1978) 1.38
Enzymic and immunochemical properties of lysozyme. XVI. A novel synthetic approach to an antigenic reactive site by direct linkage of the relevant conformationally adjacent residues constituting the site. Biochim Biophys Acta (1976) 1.37
Enzymic and immunochemical properties of lysozyme. Evaluation of several amino group reversible blocking reagents. Biochemistry (1970) 1.37
Periodate oxidation of sperm-whale myoglobin and the role of the methionine residues in the antigen-antibody reaction. Biochem J (1967) 1.34
Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis. Biochem J (1977) 1.28
Delineation of the third antigenic site of lysozyme by application of a novel 'surface-simulation' synthetic approach directly linking the conformationally adjacent residues forming the site. Biochem J (1976) 1.27
Antigenic structures of proteins. Their determination has revealed important aspects of immune recognition and generated strategies for synthetic mimicking of protein binding sites. Eur J Biochem (1984) 1.27
Immunochemistry of sperm whale myoglobin. IV. The role of the arginine residues in the conformation and differentiation of their roles in the antigenic reactivity. Biochemistry (1969) 1.24
Chemical studies on haemoglobins A1 and A0. Biochem J (1964) 1.23
T cell clones reactive with sperm whale myoglobin. Isolation of clones with specificity for individual determinants on myoglobin. J Exp Med (1981) 1.23
Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites. Mol Cell Biochem (1980) 1.13
Enzymic and immunochemical properties of lysozyme. XIX. Definition of the direction and conformational restrictions of the antigenic site around the disulfide bonds 64-80 and 76-94 (site 2) by 'surface-simulation' synthesis. Biochim Biophys Acta (1977) 1.09
Antibody-combining sites can be mimicked synthetically. Surface-simulation synthesis of the immunoglobulin new combining site to the gamma-hydroxyl derivative of vitamin K1. J Biol Chem (1978) 1.09
Enzymic and immunochemical properties of lysozyme. I. Derivatives modified at tyrosine. Influence of nature of modification on activity. Biochemistry (1969) 1.07
Genetic control of immune response to sperm whale myoglobin in mice. II. T lymphocyte proliferative response to the synthetic antigenic sites. J Immunol (1979) 1.07
Enzymic and immunochemical properties of lysozyme. VII. Location of all the antigenic reactive regions. A new approach to study immunochemistry of tight proteins. Biochim Biophys Acta (1973) 1.07
Localization and synthesis of the acetylcholine-binding site in the alpha-chain of the Torpedo californica acetylcholine receptor. Biochem J (1984) 1.07
Enzymic and immunochemical properties of lysozyme. XIII. Accurate delineation of the reactive site around the disulfide 6-127 by immunochemical study of beta-propiolactone lysozyme derivative and of synthetic disulfide peptides. Biochim Biophys Acta (1976) 1.06
Antibodies with specificities to preselected protein regions evoked by free synthetic peptides representing protein antigenic sites or other surface locations: demonstration with myoglobin. Mol Immunol (1983) 1.06
Immunochemistry of sperm-whale myoglobins prepared with various modified porphyrins and metalloporphyrins. Biochem J (1967) 1.06
Congenital myasthenic syndromes: II. Syndrome attributed to abnormal interaction of acetylcholine with its receptor. Muscle Nerve (1993) 1.05
Preparation of T-lymphocyte lines and clones with specificities to preselected protein sites by in vitro passage with free synthetic peptides: demonstration with myoglobin sites. Mol Immunol (1983) 1.05
Localization, synthesis, and activity of an antigenic site on influenza virus hemagglutinin. Proc Natl Acad Sci U S A (1983) 1.05
T cell recognition of ragweed allergen Ra3: localization of the full T cell recognition profile by synthetic overlapping peptides representing the entire protein chain. Eur J Immunol (1986) 1.04
Specific cleavage of tryptophyl peptide bonds with periodate in sperm whale myoglobin. Arch Biochem Biophys (1967) 1.04
Region of peptide 125-147 of acetylcholine receptor alpha subunit is exposed at neuromuscular junction and induces experimental autoimmune myasthenia gravis, T-cell immunity, and modulating autoantibodies. Proc Natl Acad Sci U S A (1985) 1.04
Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis. Biochem J (1978) 1.01
Structurally inherent antigenic sites. Localization of the antigenic sites of the alpha-chain of human haemoglobin in three host species by a comprehensive synthetic approach. Biochem J (1982) 1.00
Lack of immunochemical cross-reaction between lysozyme and alpha-lactalbumin and comparison of their conformations. Biochim Biophys Acta (1970) 1.00
Immunochemistry of sperm-whale myoglobin. XIX. Accurate delineation of the single reactive region in sequence 54-85 by immunochemical study of synthetic peptides. Biochim Biophys Acta (1974) 0.99
Immunochemistry of sperm whale myoglobin. 3. Modification of the three tyrosine residues and their role in the conformation and differentiation of their roles in the antigenic reactivity. Biochemistry (1968) 0.99
Immunochemistry of sperm whale of myoglobin. IX. Specific interaction of peptides obtained by cleavage at arginine peptide bonds. Biochemistry (1971) 0.98
Localization and verification by synthesis of five antigenic sites of bovine serum albumin. Biochem J (1979) 0.98
Synthesis of an antigenic site of native acetylcholine receptor peptide 159-169 of Torpedo acetylcholine receptor alpha-chain. Biochem J (1985) 0.98
Enzymic and immunochemical properties of lysozyme-XII. Delineation of the reactive site around the two central disulfides by immunochemical and conformational studies of derivatives of the two-disulfide peptide. Immunochemistry (1976) 0.97
Antigen presentation of lysozyme: T-cell recognition of peptide and intact protein after priming with synthetic overlapping peptides comprising the entire protein chain. Immunology (1985) 0.97
Enzymic and immunochemical properties of lysozyme. IV. Demonstration of conformational differences between alpha-lactalbumin and lysozyme. Biochim Biophys Acta (1971) 0.97
Immunochemistry of sperm whale myoglobin. VII. Correlation of immunochemical cross-reaction of eight myoglobins with structural similarity and its dependence on conformation. Biochim Biophys Acta (1970) 0.96
Segment alpha 182-198 of Torpedo californica acetylcholine receptor contains second toxin-binding region and binds anti-receptor antibodies. FEBS Lett (1986) 0.95
Enzymic and immunochemical properties of lysozyme--XV. Delineation of the reactive site around the two central disulfides by immunochemical studies of novel synthetic peptides that contain diglycyl bridges instead of disulfides. Immunochemistry (1976) 0.95
Haemoglobin binding with haptoglobin. Unequivocal demonstration that the beta-chains of human haemoglobin bind to haptoglobin. Biochem J (1980) 0.95
Enzymic and immunochemical properties of lysozyme. XI. Conformation and immunochemistry of the two-disulfide peptide and the tryptophan and lysine residues in its antigenic reactivity. Biochim Biophys Acta (1975) 0.94
Immunochemistry of sperm whale myoglobin. VI. Preparation and conformational analysis of eight mammalian myoglobins. Biochim Biophys Acta (1970) 0.94
Antigenic structure of human haemoglobin. Localization of the antigenic sites of the beta-chain in three host species by synthetic overlapping peptides representing the entire chain. Biochem J (1986) 0.93
Immunochemistry of sperm-whale myoglobin--XXII. Accurate delineation of the single reactive region in sequence 103-120 by immunochemical studies of synthetic peptides: the complete antigenic structure of the protein. Immunochemistry (1975) 0.93
Antibody recognition of ragweed allergen Ra3: localization of the full profile of the continuous antigenic sites by synthetic overlapping peptides representing the entire protein chain. Eur J Immunol (1986) 0.93
Immunochemistry of sperm whale myoglobin. X. Regions responsible for immunochemical cross-reaction with finback whale myoglobin. Some general conclusions concerning immunochemical cross-reaction of proteins. Biochemistry (1971) 0.93
A fragment comprising the last third of bovine serum albumin which accounts for almost all the antigenic reactivity of the native protein. J Biol Chem (1976) 0.93
Molecular localization of the full profile of the continuous regions recognized by myoglobin-primed T-cells using synthetic overlapping peptides encompassing the entire molecule. Immunol Commun (1983) 0.93
Conformation-dependent recognition of a protein by T-lymphocytes: apomyoglobin-specific T-cell clone recognizes conformational changes between apomyoglobin and myoglobin. Immunol Invest (1988) 0.92
A novel approach for localization of the continuous protein antigenic sites by comprehensive synthetic surface scanning: antibody and T-cell activity to several influenza hemagglutinin synthetic sites. Immunol Commun (1984) 0.92
Immunochemistry of sperm-whale myoglobin--XXIII. Investigation of the independence of the five antigenic reactive regions by immunoabsorbent studies. Immunochemistry (1975) 0.92
T lymphocyte recognition of acetylcholine receptor: localization of the full T cell recognition profile on the extracellular part of the alpha chain of Torpedo californica acetylcholine receptor. Eur J Immunol (1987) 0.91
T cell recognition of lysozyme. IV. Localization and genetic control of the continuous T cell recognition sites by synthetic overlapping peptides representing the entire protein chain. J Immunogenet (1985) 0.91
Antibody combining sites can be mimicked synthetically. Surface-simulation synthesis of the phosphorylcholine-combining site of myeloma protein M-603. Biochem J (1980) 0.91
Distance calculation of residues neighbouring to lysozyme antigenic sites. Site-neighbouring residues whose evolutionary substitution can modify the characteristics and binding energy of the sites. Biochem J (1980) 0.91
Hemoglobin binding with haptoglobin: delineation of the haptoglobin binding site on the alpha-chain of human hemoglobin. J Protein Chem (1990) 0.91
Conformational studies on modified proteins and peptides. 3. Conformation of peptides obtained by cleavage of myoglobin at arginine peptide bonds. J Biol Chem (1970) 0.91
Immune recognition of serum albumin--XIII. Autoreactivity with rabbit serum albumin of rabbit antibodies against bovine or human serum albumins and autoimmune recognition of rabbit serum albumin. Mol Immunol (1981) 0.91
Conformational studies on modified proteins and peptides. VII. Conformation of epsilon-prototoxin and epsilon-toxin from Clostridium perfringens. Conformational changes associated with toxicity. Biochim Biophys Acta (1973) 0.90
High yield coupling of peptides to protein carriers. Biochim Biophys Acta (1981) 0.90
Immunochemical studies of hemoglobin and the role of the sulfhydryl groups. Immunochemistry (1965) 0.89
Immunochemistry of sperm whale myoglobin. II. Modification of the two tryptophan residues and their role in the conformation and antigen-antibody reaction. Biochemistry (1968) 0.89
Localization of the functional sites on the alpha chain of acetylcholine receptor. Fed Proc (1987) 0.89
Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control. J Immunol (1978) 0.88
Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region alpha 146-162 of acetylcholine receptor. Clin Immunol Immunopathol (1993) 0.88
Conformational studies on modified proteins and peptides. IV. Conformation of lysozyme derivatives modified at tyrosine or at tryptophan residues. J Biol Chem (1971) 0.88
T cell recognition of myoglobin. Localization of the sites stimulating T cell proliferative responses by synthetic overlapping peptides encompassing the entire molecule. J Immunogenet (1985) 0.88
Can an antibody-combining site be mimicked synthetically? The possible surface simulation synthesis of two antibody-combining sites complementary to two antigenic sites of lysozyme. J Biol Chem (1977) 0.88
Immunochemistry of serum albumin. X. Five major antigenic sites of human serum albumin are extrapolated from bovine albumin and confirmed by synthetic peptides. Mol Immunol (1980) 0.88
Acetylcholine receptor-alpha-bungarotoxin interactions: determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity. Proc Natl Acad Sci U S A (1990) 0.87
The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors. Biochem J (1991) 0.87
Enzymic and immunochemical properties of lysozyme. V. Derivatives modified at lysine residues by guanidination, acetylation, succinylation or maleylation. Immunochemistry (1971) 0.87
Immunochemistry of serum albumin--II. Isolation and characterization of a fragment from the first third of bovine serum albumin carrying almost all the antigenic reactivity of the protein. Immunochemistry (1976) 0.87
Conformational studies on modified proteins and peptides. Artificial myoglobins prepared with modified and metalloporphyrins. Biochemistry (1970) 0.87
Haemoglobin binding with haptoglobin. Localization of the haptoglobin-binding site on the alpha-chain of human haemoglobin. Biochem J (1981) 0.87
Haemoglobin binding with haptoglobin. Localization of the haptoglobin-binding sites on the beta-chain of human haemoglobin by synthetic overlapping peptides encompassing the entire chain. Biochem J (1986) 0.86
T cell recognition of lysozyme. III. Recognition of the 'surface-simulation' synthetic antigenic sites. J Immunogenet (1985) 0.86
Profile of the alpha-bungarotoxin-binding regions on the extracellular part of the alpha-chain of Torpedo californica acetylcholine receptor. Biochem J (1987) 0.86
Discovery and implications of the immunogenicity of free small synthetic peptides: powerful tools for manipulating the immune system and for production of antibodies and T cells of preselected submolecular specificities. Crit Rev Immunol (1985) 0.85
Immunochemistry of serum albumin--IV. Immunochemical cross-reaction of fragments from the first third and the last third of bovine serum albumin. Immunochemistry (1977) 0.85
Conformation and immunochemistry of methylated and carboxymethyulated derivatives of lysozyme. Biochemistry (1973) 0.85
T-lymphocyte recognition of sperm-whale myoglobin. Recognition of synthetic peptides carrying antigenic site 5 by myoglobin-primed T-cells. J Immunogenet (1983) 0.85
Genetic control of the immune response to haemoglobin. III. Variant A beta (bm12) but not Ae (D2.GD) Ia polypeptides alter immune responsiveness towards the alpha -subunit of human haemoglobin. J Immunogenet (1981) 0.85
T-cell recognition of lysozyme. I. Localization of regions stimulating T-cell proliferative response by synthetic overlapping peptides encompassing the entire molecule. Exp Clin Immunogenet (1984) 0.85
Association with HLA DQ of early onset myasthenia gravis in Southeast Texas region of the United States. Int J Immunogenet (2010) 0.85
Enzymic and immunochemical properties of lysozyme. IX. Conformation and immunochemistry of derivatives succinylated at certain lysine residues. Biochim Biophys Acta (1975) 0.84
Immune recognition of serum albumin.15. Localization by synthesis of antigenic site 4 of bovine serum albumin to the region around the disulfide bond 166-175. Biochim Biophys Acta (1982) 0.84