Published in J Neurosurg on June 01, 1985
Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm (2009) 1.22
LF 16-0687 Ms, a bradykinin B2 receptor antagonist, reduces ischemic brain injury in a murine model of transient focal cerebral ischemia. Br J Pharmacol (2003) 1.04
Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc Natl Acad Sci U S A (1997) 0.99
Towards clinical management of traumatic brain injury: a review of models and mechanisms from a biomechanical perspective. Dis Model Mech (2013) 0.98
Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: evaluation by conditioned fear response. Behav Brain Res (2006) 0.97
Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol (2006) 0.91
BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy. Proc Natl Acad Sci U S A (1999) 0.91
Effects of tert-butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice. Mediators Inflamm (2011) 0.88
Low doses of dexamethasone decrease brain water content of collagenase-induced cerebral hematoma. Can J Vet Res (2003) 0.87
The CRASH trial protocol (Corticosteroid randomisation after significant head injury) [ISRCTN74459797]. BMC Emerg Med (2001) 0.83
A novel mouse model of penetrating brain injury. Front Neurol (2014) 0.82
High doses of methylprednisolone are required for the treatment of collagenase-induced intracerebral hemorrhage in rats. Can J Vet Res (2005) 0.82
Effects of timing of dexamethasone treatment on the outcome of collagenase-induced intracerebral hematoma in rats. Comp Med (2009) 0.81
Protective effects of fluoxetine on decompression sickness in mice. PLoS One (2012) 0.78
Blood-brain barrier permeability and vascular reactivity to bradykinin after pretreatment with dexamethasone. Acta Neuropathol (1989) 0.76
Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution. Transpl Int (1993) 0.75
Crash. J R Soc Med (2002) 0.75
The CRASH trial: the first large-scale, randomised, controlled trial in head injury. Crit Care (2001) 0.75
Ophthalmoplegia associated with transorbital penetrating brainstem injury by broken fishing pole. Clin Ophthalmol (2011) 0.75
Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the "spadin" Antidepressant. Front Physiol (2016) 0.75
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol (1996) 2.82
Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone. J Neurotrauma (2000) 2.30
HPLC-chemiluminescence and thermospray LC/MS study of hydroperoxides generated from phosphatidylcholine. Free Radic Biol Med (1995) 1.41
Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem (1998) 1.38
Pathophysiology of spinal cord trauma. Ann Emerg Med (1993) 1.32
Estrogen-related gender difference in survival rate and cortical blood flow after impact-acceleration head injury in rats. J Neurotrauma (2000) 1.25
Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radic Biol Med (1989) 1.21
A comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats. Stroke (2001) 1.12
Treatment of mice with methamphetamine produces cell loss in the substantia nigra. Brain Res (1996) 1.10
The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury. J Neurotrauma (2001) 1.09
4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration. Chem Res Toxicol (2000) 1.09
Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog. Exp Neurol (2007) 1.04
Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis. Neurology (1998) 1.03
Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium. Cent Nerv Syst Trauma (1985) 1.03
Ovariectomy exacerbates and estrogen replacement attenuates photothrombotic focal ischemic brain injury in rats. Stroke (2000) 1.02
Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J Neurotrauma (1996) 1.00
Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord (2005) 1.00
A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells. J Pharmacol Exp Ther (1988) 0.99
Glucocorticoid mechanisms in acute spinal cord injury: a review and therapeutic rationale. Surg Neurol (1982) 0.98
Current application of "high-dose" steroid therapy for CNS injury. A pharmacological perspective. J Neurosurg (1985) 0.97
Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury. J Neurosurg (1987) 0.97
A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage. J Pharmacol Exp Ther (1987) 0.97
Involvement of lipid peroxidation in CNS injury. J Neurotrauma (1992) 0.96
A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia. J Neurosurg (1986) 0.95
U-54494A: a unique anticonvulsant related to kappa opioid agonists. J Pharmacol Exp Ther (1987) 0.95
Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J Neurotrauma (1994) 0.95
Role of lipid peroxidation in post-traumatic spinal cord degeneration: a review. Cent Nerv Syst Trauma (1986) 0.92
Comparison of the efficacy of mechanistically different antioxidants in the rat hemorrhagic shock model. Circ Shock (1991) 0.92
Correlation of methylprednisolone levels in cat spinal cord with its effects on (Na+ + K+)-ATPase, lipid peroxidation, and alpha motor neuron function. J Neurosurg (1982) 0.91
Glucocorticoid effects on the electrical properties of spinal motor neurons. Brain Res (1982) 0.90
Tirilazad mesylate protects vitamins C and E in brain ischemia-reperfusion injury. J Neurochem (1992) 0.89
Effects of multi-dose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism. J Neurosurg (1984) 0.89
Lactate and pyruvate metabolism in injured cat spinal cord before and after a single large intravenous dose of methylprednisolone. J Neurosurg (1983) 0.88
Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. J Med Chem (1998) 0.87
Lipid peroxidation and the role of oxygen radicals in CNS injury. Acta Anaesthesiol Belg (1987) 0.86
Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase. Pathol Biol (Paris) (1996) 0.86
Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue. Exp Neurol (1981) 0.84
Effects of treatment with U-74006F on neurological outcome following experimental spinal cord injury. J Neurosurg (1988) 0.84
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma. J Med Chem (1990) 0.83
Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain. J Neurochem (1993) 0.82
Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and Na+ + K+)-ATPase activity. Dose-response analysis during 1st hour after contusion injury in the cat. J Neurosurg (1982) 0.82
Infant rat model of the shaken baby syndrome: preliminary characterization and evidence for the role of free radicals in cortical hemorrhaging and progressive neuronal degeneration. J Neurotrauma (1998) 0.82
Effects of a single large dose of methylprednisolone sodium succinate on experimental posttraumatic spinal cord ischemia. Dose-response and time-action analysis. J Neurosurg (1984) 0.82
Neuroprotective efficacy and mechanisms of novel pyrrolopyrimidine lipid peroxidation inhibitors in the gerbil forebrain ischemia model. J Cereb Blood Flow Metab (1998) 0.81
The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury. Reversal by tirilazad mesylate (U-74006F). Mol Chem Neuropathol (1993) 0.81
Effects of a 21-aminosteroid (U-74006F) on cerebral metabolites and edema after severe experimental head trauma. Adv Neurol (1990) 0.81
Acute cardiovascular response to a single large intravenous dose of methylprednisolone and its effects on the responses to norepinephrine and isoproterenol. Proc Soc Exp Biol Med (1983) 0.80
A comparison of the effects of tirilazad on subarachnoid hemorrhage-induced blood-brain barrier permeability in male and female rats. J Stroke Cerebrovasc Dis (2007) 0.80
Neuroprotective effects of the dopamine agonists pramipexole and bromocriptine in 3-acetylpyridine-treated rats. Brain Res (1997) 0.80
Dextran-coupled deferoxamine improves outcome in a murine model of head injury. J Neurotrauma (1992) 0.80
Neuroprotective effects of the novel brain-penetrating pyrrolopyrimidine antioxidants U-101033E and U-104067F against post-ischemic degeneration of nigrostriatal neurons. J Neurosci Res (1997) 0.80
Acute manganese toxicity and the absorption and biliary excretion of manganese in cattle. Res Vet Sci (1983) 0.80
Methylprednisolone preservation of motor nerve function during early degeneration. Exp Neurol (1984) 0.79
Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase. Cent Nerv Syst Trauma (1985) 0.79
Mechanisms of neuronal degeneration secondary to central nervous system trauma or ischemia. J Neurotrauma (1989) 0.79
Intensive anti-oxidant pretreatment retards motor nerve degeneration. Brain Res (1987) 0.79
LC-MS/MS detection of peroxynitrite-derived 3-nitrotyrosine in rat microvessels. Free Radic Biol Med (2000) 0.79
Beneficial action of glucocorticoid treatment on neuromuscular transmission during early motor nerve degeneration. Exp Neurol (1983) 0.79
Mutant CuZn superoxide dismutase in motor neuron disease. J Inherit Metab Dis (1998) 0.78
Direct measurement of lipid hydroperoxides in iron-dependent spinal neuronal injury. J Neurochem (1996) 0.78
Corticosteroid therapy in experimental cord injury. J Neurosurg (1984) 0.78
Induction of apolipoprotein E mRNA in the hippocampus of the gerbil after transient global ischemia. Brain Res Mol Brain Res (1996) 0.78
Acute effects of methylprednisolone sodium succinate on spinal reflexes. Exp Neurol (1979) 0.78
Uptake and elimination of methylprednisolone from contused cat spinal cord following intravenous injection of the sodium succinate ester. J Neurosurg (1983) 0.78
Effect of delayed administration of U74006F (tirilazad mesylate) on recovery of locomotor function after experimental spinal cord injury. J Neurotrauma (1991) 0.78
Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone. Brain Res (1981) 0.78
Acute effects of intravenous glucocorticoid on cat spinal motor neuron electrical properties. Brain Res (1982) 0.78
Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J Med Chem (1995) 0.78
Glucocorticoid effects on central nervous excitability and synaptic transmission. Int Rev Neurobiol (1982) 0.77
Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia. Brain Res (1994) 0.77
Effects of the lipid peroxidation inhibitor tirilazad mesylate (U-74006F) on gerbil brain eicosanoid levels following ischemia and reperfusion. Brain Res (1994) 0.77
Glucocorticoid effects on spinal cord function. J Pharmacol Exp Ther (1978) 0.77
A new class of compounds for stroke and trauma: effects of 21-aminosteroids on lipid peroxidation. Acta Anaesthesiol Belg (1987) 0.77
Glucocorticoid enhancement of serotonergic facilitation of cat spinal monosynaptic motor neuron excitation. Exp Neurol (1980) 0.77
Age-related phospholipid hydroperoxide levels in gerbil brain measured by HPLC-chemiluminescence and their relation to hydroxyl radical stress. Brain Res (1994) 0.76
Surgical procedure for modifying the duodenum in cattle to measure bile flow and the diurnal variation in biliary manganese, iron, copper and zinc excretion. Res Vet Sci (1982) 0.76
Role of oxygen-derived free radicals in the pathogenesis of shock and trauma, with focus on central nervous system injuries. J Am Vet Med Assoc (1992) 0.76
Two novel pyrrolopyrimidine lipid peroxidation inhibitors U-101033E and U-104067F protect facial motor neurons following neonatal axotomy. Exp Neurol (1996) 0.76
Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury. J Neurosurg (1996) 0.76
Protective effects of tirilazad mesylate in a cellular model of peroxynitrite toxicity. Res Commun Mol Pathol Pharmacol (1996) 0.76
Amelioration of impaired cerebral metabolism after severe acidotic ischemia by tirilazad posttreatment in dogs. Stroke (1996) 0.76
The effects of chronic two-fold dietary vitamin E supplementation on subarachnoid hemorrhage-induced brain hypoperfusion. Brain Res (1987) 0.76
Neuroprotective effects of the GABA(A) receptor partial agonist U-101017 in 3-acetylpyridine-treated rats. Neurosci Lett (1997) 0.76
Post-traumatic spinal cord ischemia: relationship to injury severity and physiological parameters. Cent Nerv Syst Trauma (1987) 0.76
U74389G prevents vasospasm after subarachnoid hemorrhage in dogs. Neurosurgery (1998) 0.76
Pathophysiology of spinal cord injury. Current and future therapies. Minerva Anestesiol (1989) 0.76
Further studies of glucocorticoid effects on spinal cord function: single and repetitive monosynaptic transmission and apparent Ia afferent transmitter turnover. J Pharmacol Exp Ther (1979) 0.76
"High-dose" methylprednisolone and CNS injury. J Neurosurg (1986) 0.76
Effects of methylprednisolone and 21-aminosteroids on mitogen-induced interleukin-6 and tumor necrosis factor-alpha production in human peripheral blood mononuclear cells. J Pharmacol Exp Ther (1995) 0.76
Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome. J Neurotrauma (1998) 0.76
Effect of the aminosteroid U74006F after cardiopulmonary arrest in dogs. Stroke (1988) 0.76
Mutant Cu,Zn superoxide dismutase in motor neuron disease. Age (Omaha) (1998) 0.75
Methylprednisolone, head trauma, and brain protection. Anesth Analg (1993) 0.75
Where should the O. R. nurse receive training? The campus? The hospital? Hosp Manage (1966) 0.75
Glucocorticoid modification of spinal dopamine receptor activation by apomorphine. Brain Res (1983) 0.75
Pharmacokinetics of methylprednisolone in cat plasma and spinal cord following a single intravenous dose of the sodium succinate ester. Drug Metab Dispos (1983) 0.75
Age-related phospholipid hydroperoxide levels in gerbil brain measured by HPLC-chemiluminescence assay and their relation to hydroxyl radical stress--clinical implications. Adv Exp Med Biol (1994) 0.75
Actions of guanidine hydrochloride on cat spinal monosynaptic reflex transmission. Neuropharmacology (1983) 0.75
Determination of methylprednisolone in central nervous tissue and plasma using normal-phase high-performance liquid chromatography. J Chromatogr (1982) 0.75
Maximum capacity of the bovine liver to remove manganese from portal plasma and the effect of the route of entry of manganese on its rate of removal. Res Vet Sci (1982) 0.75