Published in Br J Pharmacol on August 01, 1985
A modification of receptor theory. Br J Pharmacol Chemother (1956) 14.20
The relative contribution of affinity and efficacy to agonist activity: organ selectivity of noradrenaline and oxymetazoline with reference to the classification of drug receptors. Br J Pharmacol (1984) 1.29
Determination of dissociation constants and relative efficacies of oxotremorine analogs at muscarinic receptors in the guinea-pig ileum by pharmacological procedures. J Pharmacol Exp Ther (1984) 1.10
Affinity, efficacy, and stereoselectivity of oxotremorine analogues for muscarinic receptors in the isolated guinea pig ileum. Mol Pharmacol (1983) 1.06
Phenoxybenzamine and dibenamine interactions with calcium channel effectors of the muscarinic receptor. Mol Pharmacol (1981) 0.90
Stereochemical aspects of parasympathomimetics and their antagonists: recent developments. Prog Med Chem (1975) 0.90
Relation between structure and cholinergic activity. II. Synthesis and muscarinic activity of some sulfur analogs of 2-methyl-4-trimethylammoniomethyl-1,3-dioxolane-iodide. Arzneimittelforschung (1975) 0.83
Benzilylcholine mustard and spare receptors in guinea pig ileum. Life Sci (1982) 0.83
Cholinergic compounds. V - New synthesis and further pharmacological evaluation of desethermuscarine. Farmaco Sci (1975) 0.83
Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis (2001) 2.76
High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality. Clin Microbiol Infect (2012) 1.92
Renal vasoconstriction in cirrhosis evaluated by duplex Doppler ultrasonography. Hepatology (1993) 1.69
Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis. Gastroenterology (1996) 1.68
Limitations of serum creatinine level and creatinine clearance as filtration markers in cirrhosis. Arch Intern Med (1994) 1.65
Increased nitric oxide-dependent vasorelaxation in aortic rings of cirrhotic rats with ascites. Hepatology (1994) 1.54
Nutritional and prognostic significance of insulin-like growth factor 1 in patients with liver cirrhosis. Nutrition (1997) 1.54
Splenic Doppler impedance indices: influence of different portal hemodynamic conditions. Hepatology (1996) 1.46
Portal hypertensive gastropathy: reproducibility of a classification, prevalence of elementary lesions, sensitivity and specificity in the diagnosis of cirrhosis of the liver. A NIEC multicentre study. New Italian Endoscopic Club. Ital J Gastroenterol Hepatol (1997) 1.45
Updating prognosis of cirrhosis by Cox's regression model using Child-Pugh score and aminopyrine breath test as time-dependent covariates. Ital J Gastroenterol Hepatol (1998) 1.39
The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR). Curr Drug Targets (2006) 1.35
Clinical features and survivial of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests. Hepatology (1999) 1.25
Left ventricular diastolic function in liver cirrhosis. Scand J Gastroenterol (1996) 1.25
Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. The New Italian Endoscopic Club for the study and treatment of esophageal varices (NIEC). Gastroenterology (2000) 1.24
Nasal carriage of S. aureus increases the risk of surgical site infection after major heart surgery. J Hosp Infect (2007) 1.17
Malnutrition in alcoholic and virus-related cirrhosis. Am J Clin Nutr (1996) 1.16
Antimuscarinic action of methoctramine, a new cardioselective M-2 muscarinic receptor antagonist, alone and in combination with atropine and gallamine. Eur J Pharmacol (1987) 1.13
Prognostic usefulness of hepatic vein catheterization in patients with cirrhosis and esophageal varices. Gastroenterology (1992) 1.10
Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients. J Hepatol (2001) 1.10
Clinical significance of the evaluation of hepatic reticuloendothelial removal capacity in patients with cirrhosis. Hepatology (1994) 1.07
Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis. Comparison with the Pugh score. Dig Dis Sci (1991) 1.04
Intention-to-treat analysis of liver transplantation in selected, aggressively treated HCC patients exceeding the Milan criteria. Am J Transplant (2007) 1.03
Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic? Curr Med Chem (2014) 1.02
Prognostic indicators of risk for first variceal bleeding in cirrhosis: a multicenter study in 711 patients to validate and improve the North Italian Endoscopic Club (NIEC) index. Am J Gastroenterol (2000) 1.01
Eicosanoid excretion in hepatic cirrhosis. Predominance of 20-HETE. J Clin Invest (1997) 1.00
Candida tropicalis fungaemia: incidence, risk factors and mortality in a general hospital. Clin Microbiol Infect (2010) 0.97
A cyclopentane analog of muscarone. J Med Chem (1974) 0.97
Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: relationships with portal hemodynamics. Gastroenterology (1995) 0.93
The medicinal chemistry of multidrug resistance (MDR) reversing drugs. Farmaco (2002) 0.93
Conservative medical therapy of prosthetic joint infections: retrospective analysis of an 8-year experience. Clin Microbiol Infect (2004) 0.93
Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline. Mol Pharmacol (2000) 0.92
Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn Schmiedebergs Arch Pharmacol (1988) 0.92
Aminopyrine breath test in the prognostic evaluation of patients with cirrhosis. Gut (1992) 0.90
Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis. Hepatology (1995) 0.90
Neurological complications after orthotopic liver transplantation. Dig Liver Dis (2007) 0.89
Ventilator-associated pneumonia due to meticillin-resistant Staphylococcus aureus: risk factors and outcome in a large general hospital. J Hosp Infect (2012) 0.88
Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity. Bioorg Med Chem (1997) 0.88
Teicoplanin use and emergence of Staphylococcus haemolyticus: is there a link? Clin Microbiol Infect (2006) 0.88
Microwave thermal ablation for hepatocarcinoma: six liver transplantation cases. Transplant Proc (2011) 0.87
Urinary excretion of urodilatin in patients with cirrhosis. Hepatology (1996) 0.87
Infrahepatic terminolateral cavo-cavostomy as a rescue technique in complicated "modified" piggyback liver transplantation. J Am Coll Surg (1997) 0.87
Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy and safety compared with placebo and enalapril. J Hypertens (1996) 0.86
Q-T interval prolongation in liver cirrhosis. Reversibility after orthotopic liver transplantation. Jpn Heart J (1998) 0.86
Clinical practice guidelines for the management of cirrhotic patients with ascites. Committee on Ascites of the Italian Association for the Study of the Liver. Ital J Gastroenterol Hepatol (1999) 0.86
Reversal of multidrug resistance by verapamil analogues. Biochem Pharmacol (1995) 0.84
A pathophysiological interpretation of unresponsiveness to spironolactone in a stepped-care approach to the diuretic treatment of ascites in nonazotemic cirrhotic patients. Hepatology (1991) 0.84
Irreversible alpha adrenoceptor blocking effects and reversible muscarinic blocking and nicotinic blocking effects of tetramine disulfides on the heart. Can J Physiol Pharmacol (1980) 0.84
Renal water and sodium handling in compensated liver cirrhosis: mechanism of the impaired natriuresis after saline loading. Eur J Clin Invest (1985) 0.84
Outbreak of invasive aspergillosis after major heart surgery caused by spores in the air of the intensive care unit. Clin Infect Dis (2012) 0.83
Prognostic indicators of survival in patients with cirrhosis and esophageal varices, without previous bleeding. Am J Gastroenterol (1989) 0.83
Cholinergic compounds. V - New synthesis and further pharmacological evaluation of desethermuscarine. Farmaco Sci (1975) 0.83
Nadolol for prevention of variceal rebleeding in cirrhosis: a controlled clinical trial. Digestion (1987) 0.82
2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]-methyl] -1,4-benzoxathian: a new antagonist with high potency and selectivity toward alpha 1-adrenoreceptors. J Med Chem (1984) 0.82
Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the acetylcholine releaser PG-9. Jpn J Pharmacol (1998) 0.82
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand. J Med Chem (1998) 0.82
Pandemic influenza A(H1N1) virus infection in solid organ transplant recipients: impact of viral and non-viral co-infection. Clin Microbiol Infect (2011) 0.82
Haeme oxygenase mediates hyporeactivity to phenylephrine in the mesenteric vessels of cirrhotic rats with ascites. Gut (2005) 0.82
Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance: discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range. J Med Chem (1999) 0.81
Hyperphagic effect of novel compounds with high affinity for imidazoline I(2) binding sites. Eur J Pharmacol (2000) 0.81
Hemodynamic evaluation of the addition of isosorbide-5-mononitrate to nadolol in cirrhotic patients with insufficient response to the beta-blocker alone. Hepatology (1997) 0.81
Prognostic evaluation of the donor risk index among a prospective cohort of Italian patients undergoing liver transplantation. Transplant Proc (2009) 0.81
Genotyping of a nosocomial outbreak of pandemic influenza A/H1N1 2009. J Clin Virol (2011) 0.81
Indocyanine green intrinsic hepatic clearance as a prognostic index of survival in patients with cirrhosis. J Hepatol (1989) 0.81
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity. J Med Chem (2000) 0.81
Effect of chronic treatment with nadolol plus isosorbide mononitrate on liver blood flow and liver metabolic activity in cirrhosis. Eur J Gastroenterol Hepatol (1999) 0.80
Antisense 'knockdowns' of M1 receptors induces transient anterograde amnesia in mice. Neuropharmacology (1999) 0.80
Hybridized and isosteric analogues of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action. Bioorg Med Chem (1999) 0.80
Portal hypertension and portal hypertensive gastropathy in patients with liver cirrhosis: a haemodynamic study. Dig Liver Dis (2003) 0.80
Estimation of the harm to the waiting list as a crucial factor in the selection of patients with hepatocellular carcinoma for liver transplantation. Transplant Proc (2010) 0.80
Enantiomers of 8-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydro-3-oxo-2H- (1,4)benzothiazine: racemic resolution, chiral synthesis and biological activity. Farmaco (1990) 0.80
Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci (1996) 0.80
Aquaretic effect of the kappa-opioid agonist RU 51599 in cirrhotic rats with ascites and water retention. Gastroenterology (1995) 0.80
Selective blockade of different brain stem muscarinic receptor subtypes: effects on the sleep-wake cycle. Brain Res (1994) 0.79
Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes. J Med Chem (2001) 0.79
Researches in the field of antiviral compounds. Mannich Bases of 3-hydroxycoumarin. J Med Chem (1969) 0.79
A patients' and caregivers' perspective on hepatic encephalopathy. Metab Brain Dis (2012) 0.79
Polymethylene tetraamines as muscarinic receptor probes. Trends Pharmacol Sci (1989) 0.79
Electroencephalographic analysis for the assessment of hepatic encephalopathy: comparison of non-parametric and parametric spectral estimation techniques. Neurophysiol Clin (2009) 0.79
Chain-lengthened and imidazoline analogues of nicotine. Bioorg Med Chem Lett (2000) 0.79
Constitutive inhibitory action of muscarinic receptors on adenylyl cyclase in cardiac membranes and its stereospecific suppression by hyoscyamine. Physiol Res (2002) 0.79
Plasma carnitine levels in liver cirrhosis: relationship with nutritional status and liver damage. J Clin Chem Clin Biochem (1990) 0.79
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. Cell Death Differ (2004) 0.79
Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers. CNS Drug Rev (2006) 0.79
P300 latency for the diagnosis of minimal hepatic encephalopathy: evidence that spectral EEG analysis and psychometric tests are enough. Dig Liver Dis (2005) 0.78
Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG-9. J Pharmacol Exp Ther (1998) 0.78
Donor-Model for End-Stage Liver Disease and donor-recipient matching in liver transplantation. Transplant Proc (2011) 0.78