Published in Ann N Y Acad Sci on April 30, 1971
The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. Br J Pharmacol (1972) 2.52
Prostaglandins, oxygen tension and smooth muscle tone. Br J Pharmacol (1972) 2.51
Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br J Pharmacol (1973) 2.42
Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids. Br J Pharmacol (1978) 2.41
Pyrogen fever and prostaglandin-like activity in cerebrospinal fluid. J Physiol (1973) 2.33
The contribution of prostaglandin production to contractions of the isolated uterus of the rat. Br J Pharmacol (1973) 2.33
Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin. Br J Pharmacol (1982) 2.01
Release of prostaglandin by mitogen- and antigen-stimulated leukocytes in culture. J Clin Invest (1974) 2.01
The action of sodium cromoglycate on 'C' fibre endings in the dog lung. Br J Pharmacol (1980) 1.95
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin. J Clin Invest (1974) 1.89
Isolation and purification of human large bowel mucosal lymphoid cells: effect of separation technique on functional characteristics. Gut (1979) 1.88
Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol (1994) 1.82
Proceedings: Prostaglandin generation maintains the smooth muscle tone of the rabbit isolated jejunum. Br J Pharmacol (1972) 1.80
Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction. J Clin Invest (1974) 1.76
The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins. Br J Pharmacol (1972) 1.65
The antipyretic effect of indomethacin. J Physiol (1975) 1.51
The release of spasmogenic substances from human chopped lung tissue and its inhibition. Br J Pharmacol (1973) 1.48
Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen. Br J Pharmacol (1973) 1.47
Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype. Thorax (2015) 1.46
Induction of bronchial hypersensitivity: evidence for a role for prostaglandins. Thorax (1981) 1.34
Prostaglandin production by rabbit isolated jejunum and its relationship to the inherent tone of the preparation. Br J Pharmacol (1976) 1.29
The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat. Br J Pharmacol (1972) 1.27
Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy. Ann Rheum Dis (1976) 1.27
The interaction between indomethacin and contractile agents on human isolated airway muscle. Br J Pharmacol (1980) 1.27
Behaviour of short and long latency components of the stretch reflex in human muscle. J Physiol (1975) 1.26
Multiple exercise and histamine challenge in asthmatic patients. Thorax (1980) 1.26
Prostaglandins, bioassay and inflammation. Br J Pharmacol (2006) 1.24
Relationship of prostaglandin secretion by rabbit alveolar macrophages to phagocytosis and lysosomal enzyme release. Biochem J (1979) 1.23
Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs. J Clin Invest (1984) 1.20
The release of prostaglandins and thromboxanes from guinea-pig lung by slow reacting substance of anaphylaxis, and its inhibition. Br J Pharmacol (1978) 1.18
Effect of maximal respiratory manoeuvres on bronchial sensitivity of asthmatic patients as compared to normal people. Br Med J (1975) 1.16
Mechanism and modification of bradykinin-induced coronary vasodilation. Proc Natl Acad Sci U S A (1975) 1.15
Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin. Br J Pharmacol (1972) 1.11
Rabbit-aorta contracting substance (RCS) may be a prostaglandin precursor. Br J Pharmacol (1971) 1.08
Pulmonary vascular effects of fat emulsion infusion in unanesthetized sheep. Prevention by indomethacin. J Clin Invest (1978) 1.01
Stimulation of the antigen-induced contraction of guinea-pig trachea and immunological release of histamine and SRS-A from sensitized guinea-pig lung by (2-isopropyl-3-indolyl)-3 pyridyl ketone (L8027) and indomethacin. Br J Pharmacol (1980) 1.00
Time-dependent effect of prostaglandin E2 inhalation on airway responses to bronchoconstrictor agents in normal subjects. Thorax (1982) 0.99
Participation of the prostaglandins in the control of renal blood flow during acute reduction of cardiac output in the dog. J Clin Invest (1981) 0.98
Calcium-dependent action of osmolality on adenosine 3',5'-monophosphate accumulation in rat renal inner medulla: evidence for a relationship to calcium-responsive arachidonate release and prostaglandin synthesis. J Clin Invest (1980) 0.94
Evidence against a physiological role of prostaglandins in the regulation of noradrenaline release in the cat spleen. J Physiol (1975) 0.92
Adenosine-induced coronary release of prostacyclin at normal and low pH in isolated heart of rabbit. Br J Pharmacol (1985) 0.91
Physiology and pharmacology of prostaglandins. Dig Dis Sci (1986) 0.88
Regulation of secretion in Clara cells: studies using the isolated perfused rat lung. J Clin Invest (1981) 0.87
Primary pulmonary hypertension. Br Heart J (1983) 0.86
Salicylate-induced noncardiogenic pulmonary edema. West J Med (1979) 0.85
The neuronal origin of prostaglandin released from the rabbit portal vein in response to electrical stimulation. Br J Pharmacol (1978) 0.84
Ibuprofen in acute-care therapy. Ann Surg (1990) 0.83
Prostaglandin biosynthesis in pulmonary macrophages. Am J Pathol (1979) 0.81
Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung. Br J Pharmacol (1984) 0.81
Prostaglandins and asthma. Br J Clin Pharmacol (1975) 0.81
Increased renal secretion of norepinephrine and prostaglandin E2 during sodium depletion in the dog. J Clin Invest (1980) 0.81
Regulation of allergic responses by prostaglandins: a review. J R Soc Med (1980) 0.81
Stimulation of prostaglandin E2 synthesis by exogenous phospholipase A2 and C in rabbit kidney medulla slices. Biochem J (1984) 0.80
Coagulation studies in rheumatic heart disease. Br Heart J (1980) 0.80
Proceedings: Some unexpected pharmacological effects of p-chlorophenylalanine methyl ester (PCPA) methyl ester). Br J Pharmacol (1974) 0.80
Nobel lecture. Adventures and excursions in bioassay--the stepping stones to prostacyclin. Postgrad Med J (1983) 0.79
Pattern of total and regional lung function in subjects with bronchoconstriction induced by 15-me PGF2 alpha. Thorax (1976) 0.79
Prostaglandin E2 formation by the gall bladder in experimental cholecystitis. Gut (1986) 0.79
Mechanistic Perspectives of Maslinic Acid in Targeting Inflammation. Biochem Res Int (2015) 0.78
Myocardial synthesis of prostaglandin-like substances and coronary reactions to cardiostimulation and to hypoxia. Br J Pharmacol (1979) 0.78
Hydrostatic pulmonary oedema is not a stimulus for prostaglandin synthesis in isolated, perfused lungs [proceedings]. Br J Pharmacol (1977) 0.78
Nobel lecture, 8th December 1982. Adventures and excursions in bioassay: the stepping stones to prostacyclin. Br J Pharmacol (1983) 0.78
Corneal reepithelialization and anti-inflammatory agents. Trans Am Ophthalmol Soc (1982) 0.78
Prostacyclin concentrations and transitional circulation in preterm infants requiring mechanical ventilation. Arch Dis Child Fetal Neonatal Ed (1999) 0.78
Seasonal variations of cough reflex sensitivity in elite athletes training in cold air environment. Cough (2012) 0.77
Release of prostaglandins in experimental immunecomplex endophthalmitis and phacoallergic uveitis. Br J Ophthalmol (1978) 0.77
Prostaglandin endoperoxides and thromboxanes: formation and effects. Naunyn Schmiedebergs Arch Pharmacol (1977) 0.77
Prostaglandin release in canine acute haemorrhagic pancreatitis. Gut (1976) 0.77
Inhibition of pulmonary prostaglandin metabolism by exposure of animals to oxygen or nitrogen dioxide. Biochem J (1979) 0.77
Pulmonary biosynthesis and metabolism of prostaglandins and related substances. Environ Health Perspect (1984) 0.76
Lack of release of prostaglandins from isolated perfused lungs during pulmonary hypertension and oedema. Br J Pharmacol (1979) 0.75
Some pharmacological effects of p-chlorophenylalanine unrelated to tryptophan hydroxylase inhibition. Br J Pharmacol (1976) 0.75
Slow-reacting substance of anaphylaxis. Ann R Coll Surg Engl (1978) 0.75
Effect of long-term Vitamin C intake on vascular endothelial function in diabetic children and adolescents: A pilot study. J Res Med Sci (2016) 0.75
Gas exchange by intratracheal insufflation in a ventilatory failure dog model. J Clin Invest (1992) 0.75
Bioassay of histamine in the presence of prostaglandins. Br J Pharmacol (1976) 0.75
Regulation of noradrenaline overflow in rat cerebral cortex by prostaglandin E2. Br J Pharmacol (1980) 0.75
Failure of hypoxic pulmonary vasoconstriction in the canine asthma model. Effect of prostaglandin inhibitors. J Clin Invest (1978) 0.75
The effect of indomethacin on the muscarinic induced contractions in the isolated normal guinea pig urinary bladder. BMC Urol (2013) 0.75
Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol (1990) 2.48
Towards a better aspirin. Nature (1994) 2.20
Inflammation and the mechanism of action of anti-inflammatory drugs. FASEB J (1987) 2.11
The molecular defences against reactive oxygen species in yeast. Mol Microbiol (1996) 1.73
Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1990) 1.54
Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: stimulation of guanylate cyclase and inhibition of platelet aggregation. Biochem Biophys Res Commun (1990) 1.36
The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by Escherichia coli lipopolysaccharide. Biochem Pharmacol (1992) 1.16
Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1992) 1.16
Nitric oxide from vascular smooth muscle cells: regulation of platelet reactivity and smooth muscle cell guanylate cyclase. Br J Pharmacol (1991) 1.14
The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors. Br J Pharmacol (1990) 1.11
The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action. Drugs (1987) 1.07
Splicing of the late mRNAs of polyoma virus does not occur in the cytoplasm of the infected cell. Nature (1979) 1.04
Endothelins come home to roost. Nature (1991) 1.02
Acquisition of thermotolerance in Saccharomyces cerevisiae without heat shock protein hsp 104 and in the absence of protein synthesis. FEBS Lett (1991) 1.00
Targeted gene deletion in Zygosaccharomyces bailii. Yeast (2001) 0.98
Fats and atheroma: an inquest. Br Med J (1979) 0.97
Endothelin inhibits ex vivo platelet aggregation in the rabbit. Eur J Pharmacol (1988) 0.96
Over-expression of Saccharomyces cerevisiae hsp90 enhances the virulence of this yeast in mice. FEMS Immunol Med Microbiol (1996) 0.88
Isolation of yeast plasma membranes. Methods Mol Biol (1996) 0.88
Genetic engineering and pharmaceuticals. Nature (1984) 0.86
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells. Br J Pharmacol (1993) 0.86
Cultured astrocytoma cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Biochem Biophys Res Commun (1990) 0.82
Impairment of the L-arginine-nitric oxide pathway in mast cells from spontaneously hypertensive rats. Biochem Biophys Res Commun (1991) 0.80
Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production. Adv Exp Med Biol (1993) 0.80
Diphenylene iodonium, an inhibitor of free radical formation, inhibits platelet aggregation. Eur J Pharmacol (1991) 0.80
Localization of [125I]endothelin-1 and [125I]endothelin-3 binding sites in the rat brain. Acta Physiol Scand (1989) 0.78
Cultured astrocytoma cells generate a nitric oxide-like factor from endogenous L-arginine and glyceryl trinitrate: effect of E. coli lipopolysaccharide. Br J Pharmacol (1992) 0.77
Pathways to new drugs. Scand J Infect Dis Suppl (1985) 0.76
Single coronary artery arising anomalously from the pulmonary trunk. Arch Pathol Lab Med (1983) 0.76
Studies on the importance of the proposed release of nitric oxide from platelets. Thromb Res (1991) 0.76
Nitric oxide and hypertension. Circulation (1996) 0.75
A possible role for leukotriene B4 in head and neck cancer. Br J Cancer (1989) 0.75
Re-addressing relative selectivities. Trends Pharmacol Sci (1997) 0.75
[Clinical study of prostacyclin in extracorporeal circulation. Effects on hemodynamics and coagulation]. Arch Mal Coeur Vaiss (1982) 0.75
Prostacyclin eliminates the thrombocytopenia associated with charcoal hemoperfusion and minimizes heparin and fibrinogen consumption. Artif Organs (1980) 0.75
Informational suppression in higher organisms. Nature (1978) 0.75
Trumping the ACE. Lancet (1995) 0.75
Studies of leukotriene antagonists and synthesis inhibitors in man. Prog Clin Biol Res (1988) 0.75
Pharmacology and physiology of leukotrienes and their antagonists. Ann N Y Acad Sci (1988) 0.75
Nitroblue tetrazolium inhibits oxidation of glyceryl trinitrate to nitric oxide in bovine aortic smooth muscle cells. Biochem Pharmacol (1994) 0.75