Published in Experientia on May 15, 1973
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The effects of systemic hypotension upon the human brain. Clinical and neuropathological observations in 11 cases. Brain (1966) 3.92
A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke (1979) 3.78
The lymphatic drainage of the spinal nerve roots in the rabbit. J Anat (1948) 3.49
Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science (1984) 2.85
The nature and time course of the neuronal alterations resulting from oligaemia and hypoglycaemia in the brain of Macaca mulatta. Brain Res (1971) 2.60
Neocortical death after cardiac arrest. A clinical, neurophysiological, and neuropathological report of two cases. Lancet (1971) 2.52
Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations. J Neurol Sci (1972) 1.81
Childhood hypoglycaemia. Br Med J (1972) 1.81
The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope. Br J Exp Pathol (1968) 1.78
Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed, artificially ventilated baboons. Arch Neurol (1973) 1.76
A combined light and electron microscope study of early anoxic-ischaemic cell change in rat brain. Brain Res (1970) 1.73
Prolonged epileptic seizures in primates. Ischemic cell change and its relation to ictal physiological events. Arch Neurol (1973) 1.65
The threshold and neuropathology of cerebral "anoxic-ischemic" cell change. Arch Neurol (1973) 1.57
Forebrain ischaemia with CA1 cell loss impairs epileptogenesis in the tetanus toxin limbic seizure model. Brain (1999) 1.53
Brain damage in the rhesus monkey resulting from profound arterial hypotension. I. Its nature, distribution and general physiological correlates. Brain Res (1969) 1.46
Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy. Epilepsia (1978) 1.43
Cerebral metabolic changes during prolonged epileptic seizures in rats. J Neurochem (1977) 1.42
Epilepsy and gamma-aminobutyric acid-mediated inhibition. Int Rev Neurobiol (1975) 1.42
Physiology of status epilepticus in primates. Arch Neurol (1973) 1.40
The role of epileptic activity in hippocampal and "remote" cerebral lesions induced by kainic acid. Brain Res (1980) 1.30
Anticonvulsant action of excitatory amino acid antagonists. Science (1982) 1.29
Epileptic brain damage: the role of systemic factors that modify cerebral energy metabolism. Brain (1978) 1.29
Selective chromatolysis of neurons in the gerbil brain: a possible consequence of "epileptic" activity produced by common carotid artery occlusion. Ann Neurol (1979) 1.27
Calcium overload in selectively vulnerable neurons of the hippocampus during and after ischemia: an electron microscopy study in the rat. J Cereb Blood Flow Metab (1984) 1.26
Na+ channels as targets for neuroprotective drugs. Trends Pharmacol Sci (1995) 1.25
Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase. Br J Pharmacol (1973) 1.24
Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline. Brain (1976) 1.24
Mechanism of anticonvulsant action of valproate. Prog Neurobiol (1982) 1.23
The earliest alterations in rat neurones and astrocytes after anoxia-ischaemia. Acta Neuropathol (1973) 1.20
A primate model for testing anticonvulsant drugs. Arch Neurol (1975) 1.18
Focal contralateral myoclonus produced by inhibition of GABA action in the caudate nucleus of rats. Brain (1978) 1.16
Ischaemic brain damage in the gerbil in the absence of 'no-reflow'. J Neurol Neurosurg Psychiatry (1975) 1.16
The effects of profound systemic hypotension upon the brain of M. rhesus: physiological and pathological observations. Brain (1966) 1.15
Focal myoclonus produced by injection of picrotoxin into the caudate nucleus of the rat. J Physiol (1975) 1.14
Evidence for early anoxic-ischaemic cell damage in the rat brain. Experientia (1966) 1.13
Photic and drug-induced epilepsy in the baboon (Papio papio): the effects of isoniazid, thiosemicarbazide, pyridoxine and amino-oxyacetic acid. Electroencephalogr Clin Neurophysiol (1970) 1.13
Neuropathological correlates of neurological impairment following prolonged decompression. Aerosp Med (1969) 1.11
Enzymic and cerebral metabolic effects of 2-deoxy-D-glucose. J Neurochem (1973) 1.10
Behavioural and neurological disturbances associated with hypoxic brain damage. J Neurol Sci (1973) 1.07
Factors influencing the frequency of fluorescence transients as markers of peri-infarct depolarizations in focal cerebral ischemia. Stroke (2000) 1.07
Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline or L-allylglycine. Neuroscience (1983) 1.07
Benzodiazepine receptors and their relationship to the treatment of epilepsy. Epilepsia (1986) 1.06
Cyanide intoxication in Macaca mulatta. Physiological and neuropathological aspects. J Neurol Sci (1977) 1.05
The actions of snake venoms on nerve and muscle. The pharmacology of phospholipase A and of polypeptide toxins. Pharmacol Rev (1965) 1.05
The origin of lipid phagocytes in the central nervous system: I. The intrinsic microglia. J Comp Neurol (1982) 1.04
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology (2000) 1.04
The origin of lipid phagocytes in the central nervous system: II. The adventitia of blood vessels. J Comp Neurol (1982) 1.02
Anticonvulsant action in mice with sound-induced seizures of the optical isomers of gamma-vinyl GABA. Eur J Pharmacol (1983) 1.01
Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus. Exp Brain Res (1995) 1.00
Kainic acid seizures and the reversibility of calcium loading in vulnerable neurons in the hippocampus. Neuropathol Appl Neurobiol (1984) 0.99
Anticonvulsant and proconvulsant properties of viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon. Psychopharmacology (Berl) (1982) 0.99
Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. Neuroscience (1986) 0.99
Communications between vertebro-basilar and carotid arterial circulations in the gerbil. Exp Neurol (1974) 0.98
Brief hypoxia-ischemia initially damages cerebral neurons. Arch Neurol (1975) 0.98
Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures. Arzneimittelforschung (1984) 0.98
Modulation of experimentally induced epilepsy by intracerebral grafts of fetal GABAergic neurons. Neuropsychologia (1990) 0.97
Fatal brain damage after dental anaesthesia. Its nature, etiology, and prevention. Lancet (1966) 0.97
An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus. Neurosci Lett (1987) 0.97
Status epilepticus: the reversibility of calcium loading and acute neuronal pathological changes in the rat hippocampus. Neuroscience (1984) 0.96
Cyanide intoxication in the rat: physiological and neuropathological aspects. J Neurol Neurosurg Psychiatry (1976) 0.95
Anticonvulsant effects of some calcium entry blockers in DBA/2 mice. Br J Pharmacol (1988) 0.94
Graded hypoxia-oligemia in rat brain. II. Neuropathological alterations and their implications. Arch Neurol (1973) 0.94
Long-term development of selective neuronal loss and the mechanism of protection by 2-amino-7-phosphonoheptanoate in a rat model of incomplete forebrain ischaemia. J Cereb Blood Flow Metab (1988) 0.94
Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke (1995) 0.93
Intracellular sites of early calcium accumulation in the rat hippocampus during status epilepticus. Neurosci Lett (1982) 0.93
Photically induced epilepsy in Papio papio as a model for drug studies. Adv Neurol (1975) 0.92
Delayed pentobarbital administration limits ischemic brain damage in gerbils. Ann Neurol (1979) 0.92
Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, Papio papio. Neurosci Lett (1983) 0.92
Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats. Exp Neurol (1988) 0.91
Epileptic brain damage in adolescent baboons following seizures induced by allylgycine. Brain (1974) 0.91
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration. Eur J Pharmacol (1983) 0.90
Is the erect posture in microgravity based on the control of trunk orientation or center of mass position? Exp Brain Res (1997) 0.90
The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures. Epilepsy Res (1994) 0.90
The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy. Eur J Pharmacol (1991) 0.90
Effect of excitatory amino acid antagonists on the high pressure neurological syndrome in rats. Eur J Pharmacol (1984) 0.90
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. Epilepsy Res (1991) 0.90
Effects of fetal hippocampal field grafts on ischaemic-induced deficits in spatial navigation in the water maze. Neuroscience (1993) 0.89
Remarks on the papers by C.-D. Agardh et al./H. Kalimo et al. "hypoglycemic brain injury, I, II". Acta Neuropathol (1981) 0.89
Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen. Proc Natl Acad Sci U S A (1987) 0.89
Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats. Brain Res Mol Brain Res (1996) 0.89
Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia. Lancet (1988) 0.89
Endocrine factors and glucose metabolism during prolonged seizures in baboons. Epilepsia (1979) 0.87
Cell damage in epilepsy and the role of calcium in cytotoxicity. Adv Neurol (1986) 0.87
The strychnine-like action of curare and related compounds on the somatosensory evoked response of the rat cortex. Br J Pharmacol (1969) 0.87
Convulsant and anticonvulsant actions in DBA/2 mice of compounds blocking the reuptake of GABA. Eur J Pharmacol (1979) 0.86
Gamma-aminobutyric acid and the search for new anticonvulsant drugs. Lancet (1978) 0.86
Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Neuropharmacology (2001) 0.86
Regional cerebral blood flow in the rat during prolonged seizure activity. Brain Res (1980) 0.86
A behavioral and neuropathological study of the sequelae of profound hypoxia. Brain Res (1970) 0.86
Aspartate-like and glutamate-like immunoreactivities in the inferior olive and climbing fibre system: a light microscopic and semiquantitative electron microscopic study in rat and baboon (Papio anubis). Neuroscience (1990) 0.86