Published in Br J Pharmacol on May 01, 1974
Proceedings: The relation between the plasma concentration of edrophonium, inhibition of erythrocyte acetylcholinesterase, and the facilitation of neuromuscular function in the rat. Br J Pharmacol (1975) 0.84
The relationship between the pharmacokinetics, cholinesterase inhibition and facilitation of twitch tension of the quaternary ammonium anticholinesterase drugs, neostigmine, pyridostigmine, edrophonium and 3-hydroxyphenyltrimethylammonium. Br J Pharmacol (1979) 0.75
Electrophysiological effects of edrophonium in the innervated and the transplanted denervated human heart. Br Heart J (1978) 0.75
Influence of the route of administration on the area under the plasma concentration-time curve. J Pharm Sci (1969) 1.20
The removal of 14 C-edrophonium from the circulation. Br J Pharmacol (1972) 1.16
Excretion of 14 C-edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus. Br J Pharmacol (1972) 1.11
Comparative pharmacokinetics of coumarin anticoagulants. IV. Application of a three-compartmental model to the analysis of the dose-dependent kinetics of bishydroxycoumarin elimination. J Pharm Sci (1968) 1.03
Pharmacokinetic basis for the influence of route of administration on the area under the plasma concentration-time curve. J Pharm Sci (1969) 0.89
Biliary excretion of 14 C-edrophonium and its glucuronide metabolite in Gunn rats. Arch Int Pharmacodyn Ther (1973) 0.89
Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol (1997) 2.26
The pharmacokinetics of combination therapy with nelfinavir plus nevirapine. AIDS (1998) 2.16
An investigation of the pharmacokinetics of ethynylestradiol in women using radioimmunoassay. Contraception (1979) 1.97
Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro. Antimicrob Agents Chemother (1997) 1.66
Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients. AIDS (1997) 1.65
Clinical pharmacokinetics of oral contraceptive steroids. Clin Pharmacokinet (1983) 1.64
The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites. Br J Clin Pharmacol (1987) 1.63
Differences between the biliary excretion of tri [14C] methyl-(3-hydroxy-phenyl) ammonium iodide in Wistar and Gunn rats. Biochem J (1970) 1.52
Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics. Biochem J (1992) 1.44
Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors. AIDS (1999) 1.44
The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes. Br J Clin Pharmacol (1991) 1.42
The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites. AIDS (1996) 1.41
The interaction of antibiotics with synthetic steroids in the rat [proceedings]. Br J Pharmacol (1978) 1.40
Lamivudine (3TC) phosphorylation and drug interactions in vitro. Biochem Pharmacol (1997) 1.37
Interindividual variation and drug interactions with hormonal steroid contraceptives. Drugs (1981) 1.36
The intracellular pharmacology of antiretroviral protease inhibitors. J Antimicrob Chemother (2004) 1.35
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance? AIDS (2001) 1.35
A quantitative gas-liquid chromatographic method for the determination of neostigmine and pyridostigmine in human plasma. J Chromatogr (1976) 1.29
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. Br J Clin Pharmacol (1998) 1.25
Interaction of sildenafil and indinavir when co-administered to HIV-positive patients. AIDS (1999) 1.21
Therapeutic drug monitoring as a tool in treating HIV infection. AIDS (2001) 1.18
The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids. Br J Clin Pharmacol (1990) 1.16
The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz. Br J Clin Pharmacol (2001) 1.16
The removal of 14 C-edrophonium from the circulation. Br J Pharmacol (1972) 1.16
Differences in the intracellular accumulation of HIV protease inhibitors in vitro and the effect of active transport. AIDS (2001) 1.15
Antiretroviral drug concentrations in semen of HIV-infected men: differential penetration of indinavir, ritonavir and saquinavir. J Antimicrob Chemother (2001) 1.14
Effect of chloroquine and primaquine on antipyrine metabolism. Br J Clin Pharmacol (1983) 1.13
Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users. Clin Infect Dis (2001) 1.12
Sulphation and glucuronidation of ethinyloestradiol in human liver in vitro. J Steroid Biochem (1988) 1.12
Buccal morphine--a new route for analgesia? Lancet (1985) 1.11
Pharmacokinetics of mefloquine alone or in combination with artesunate. Bull World Health Organ (1994) 1.11
Excretion of 14 C-edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus. Br J Pharmacol (1972) 1.11
Plasma and whole blood mefloquine concentrations during treatment of chloroquine-resistant falciparum malaria with the combination mefloquine-sulphadoxine-pyrimethamine. Br J Clin Pharmacol (1987) 1.10
The effect of cotrimoxazole on oral contraceptive steroids in women. Contraception (1983) 1.10
Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol (1999) 1.10
The pharmacokinetics of levonorgestrel and ethynylestradiol in women - studies with Ovran and Ovranette. Contraception (1981) 1.09
Inhibition of drug metabolism by the antimalarial drugs chloroquine and primaquine in the rat. Biochem Pharmacol (1983) 1.09
Kinetics of norethindrone in women. II. Single-dose kinetics. Clin Pharmacol Ther (1978) 1.09
A comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malaria. Eur J Clin Pharmacol (1988) 1.09
Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. Br J Pharmacol (2007) 1.09
Correlation between intracellular pharmacological activation of nucleoside analogues and HIV suppression in vitro. Antivir Chem Chemother (2000) 1.08
Saquinavir pharmacokinetics alone and in combination with nelfinavir in HIV-infected patients. AIDS (1997) 1.08
The gut wall metabolism of ethinyloestradiol and its contribution to the pre-systemic metabolism of ethinyloestradiol in humans. Br J Clin Pharmacol (1982) 1.08
Metabolism of Zidovudine. Gen Pharmacol (1995) 1.07
Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. J Pharmacol Exp Ther (1996) 1.06
Poor penetration of the male genital tract by HIV-1 protease inhibitors. AIDS (1999) 1.05
The pharmacokinetics of mefloquine in man: lack of effect of mefloquine on antipyrine metabolism. Br J Clin Pharmacol (1985) 1.04
Drug interactions with oral contraceptives. IPPF Med Bull (1978) 1.03
Plasma concentration of edrophonium in man. Clin Pharmacol Ther (1976) 1.03
The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. Br J Pharmacol (2009) 1.01
Plasma clearance of neostigmine and pyridostigmine in rats with ligated renal pedicles. Eur J Pharmacol (1973) 1.00
Effect of oral contraceptive steroids on the clinical course of malaria infection and on the pharmacokinetics of mefloquine in Thai women. Bull World Health Organ (1988) 0.99
Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in patients with the acquired immunodeficiency syndrome. Br J Clin Pharmacol (1994) 0.99
Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther (1996) 0.99
The effect of rifampicin on the pharmacokinetics of ethynylestradiol in women. Contraception (1980) 0.98
The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy. Contraception (1980) 0.98
Elevated alpha-1-acid glycoprotein reduces the volume of distribution and systemic clearance of saquinavir. Drug Metab Dispos (2001) 0.98
The lack of effect of sodium valproate on the pharmacokinetics of oral contraceptive steroids. Contraception (1986) 0.98
Histochemical characteristics and contractile properties of the spinotrapezius muscle in the rat and the mouse. J Anat (1977) 0.97
The biliary excretion of trimethyl-14C(3-hydroxyphenyl)ammonium iodide and its metabolic products. Eur J Pharmacol (1970) 0.97
Intestinal metabolism of ethinyloestradiol and paracetamol in vitro: studies using Ussing chambers. Br J Clin Pharmacol (1987) 0.97
Plasma concentration and metabolism of phenoperidine in man. Br J Anaesth (1980) 0.96
Zidovudine phosphorylation and mitochondrial toxicity in vitro. Toxicol Appl Pharmacol (2001) 0.96
Penetration of efavirenz into the male genital tract: drug concentrations and antiviral activity in semen and blood of HIV-1-infected men. AIDS (2001) 0.96
Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy. HIV Med (2010) 0.96
Quantitative gas-liquid chromatographic method for the determination of phenoperidine in human plasma. J Chromatogr (1981) 0.96
Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells. Br J Clin Pharmacol (1994) 0.96
Plasma clearance of neostigmine and pyridostigmine in the dog. Br J Pharmacol (1978) 0.96
Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive thai patients and healthy volunteers. Antimicrob Agents Chemother (2000) 0.95
The bioavailability of ethinyloestradiol and levonorgestrel in patients with an ileostomy. Contraception (1986) 0.95
Oral contraceptive steroids--pharmacological issues of interest to the prescribing physician. Adv Contracept (1991) 0.95
The pharmacokinetics of mefloquine when given alone or in combination with sulphadoxine and pyrimethamine in Thai male and female subjects. Eur J Clin Pharmacol (1987) 0.95
Interindividual variation in the metabolism of ethynylestradiol. Pharmacol Ther (1989) 0.94
Effect of mefloquine on hepatic drug metabolism in the rat: comparative study with primaquine. Biochem Pharmacol (1985) 0.94
Drug interactions with zidovudine phosphorylation in vitro. Antimicrob Agents Chemother (1995) 0.94
The in vitro metabolism of ethinyloestradiol, mestranol and levonorgestrel by human jejunal mucosa. Br J Clin Pharmacol (1981) 0.94
P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals. J Antimicrob Chemother (2002) 0.93
Renal clearance of pyridostigmine in patients with myasthenia gravis. Eur Neurol (1977) 0.93
Effect of alpha1-acid glycoprotein on the intracellular accumulation of the HIV protease inhibitors saquinavir, ritonavir and indinavir in vitro. Br J Clin Pharmacol (2001) 0.93
The effect of rifampicin on norethisterone pharmacokinetics. Eur J Clin Pharmacol (1979) 0.93
Plasma pyridostigmine levels in patients with myasthenia gravis. Clin Pharmacol Ther (1977) 0.93
Dexamethasone metabolism in vitro: species differences. J Steroid Biochem Mol Biol (1997) 0.93
Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) (1981) 0.92
Pharmacokinetics and pharmacological effects of neostigmine in man. Br J Clin Pharmacol (1979) 0.92
Inhibition of ethinyloestradiol and tolbutamide metabolism by quinoline derivatives in vitro. Chem Biol Interact (1986) 0.92
Plasma concentration of pyridostigmine and effects in myastenia gravis. Clin Pharmacol Ther (1977) 0.91
The impact of pharmacogenetics on HIV therapy. Int J STD AIDS (2009) 0.91
Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir. Br J Pharmacol (2008) 0.91
Tolbutamide 4-hydroxylase activity of human liver microsomes: effect of inhibitors. Br J Clin Pharmacol (1987) 0.91
Variability in trough plasma saquinavir concentrations in HIV patients--a case for therapeutic drug monitoring. Br J Clin Pharmacol (1998) 0.91
Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 alpha-ethinyloestradiol. Relative activities of rat and human liver enzymes. Biochem J (1990) 0.91
Intramuscular loading dose of quinine for falciparum malaria: pharmacokinetics and toxicity. Br Med J (Clin Res Ed) (1986) 0.90
Primaquine metabolism by human liver microsomes: effect of other antimalarial drugs. Biochem Pharmacol (1992) 0.90
Expression of P-glycoprotein and multidrug resistance-associated protein in healthy volunteers and HIV-infected patients. AIDS Res Hum Retroviruses (2001) 0.90
Improved oral bioavailability of lopinavir in melt-extruded tablet formulation reduces impact of third trimester on lopinavir plasma concentrations. Antimicrob Agents Chemother (2011) 0.90
The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation. Pharmacogenetics (1999) 0.89
Extrahepatic metabolism of zidovudine. Br J Clin Pharmacol (1992) 0.89
The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol (1994) 0.89