Published in J Cell Biol on April 01, 1968
Isolation of nuclear pore complexes in association with a lamina. Proc Natl Acad Sci U S A (1975) 4.46
On the attachment of the nuclear pore complex. J Cell Biol (1974) 2.95
Experimental disintegration of the nuclear envelope. Evidence for pore-connecting fibrils. J Cell Biol (1976) 1.55
The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes. Am J Pathol (1978) 1.13
Characterization of the nuclear envelope, pore complexes, and dense lamina of mouse liver nuclei by high resolution scanning electron microscopy. J Cell Biol (1977) 1.08
Quantitative analysis of rat liver nucleolar and nucleoplasmic ribosomal ribonucleic acids. Biochem J (1978) 1.06
Isolation of two distinct classes of polysomes from a nuclear fraction of rat liver. J Cell Biol (1968) 0.99
Studies with cholroplast and mitochondrial DNA. I. Evidence of sequence homology between chloroplast and nuclear DNA (Broad Bean) and between mitochondrial and nuclear DNA (rat liver). Biophys J (1972) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Simple methods for "staining with lead" at high pH in electron microscopy. J Biophys Biochem Cytol (1961) 50.33
Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol (1960) 21.27
RNA metabolism in the HeLa cell nucleus. J Mol Biol (1966) 17.11
Nuclei from rat liver: isolation method that combines purity with high yield. Science (1966) 10.35
The isolation of cell nuclei in non-aqueous media. J Gen Physiol (1952) 6.26
Isolation of pure and unaltered liver nuclei morphology and biochemical composition. Exp Cell Res (1956) 5.68
A procedure for the isolation of enzymically active rat-liver nuclei. Biochem J (1964) 4.54
Ribosomal RNA synthesis and processing in a particulate site in the HeLa cell nucleus. Science (1966) 4.43
Intracellular distribution of enzymes. IX. Certain purine-metabolizing enzymes. J Biol Chem (1952) 3.87
Free amino acids and nucleic acid content of cell nuclei isolated by a modification of Behrens' technique. J Gen Physiol (1950) 3.55
Cytochemical studies. V. On the isolation and biochemical properties of liver cell nuclei. J Biol Chem (1952) 3.55
[ULTRASTRUCTURAL CYTOCHEMISTRY OF THE NUCLEOLUS. RNA AND INTRANUCLEOLAR PROTEINS]. J Ultrastruct Res (1964) 3.16
ISOLATION OF NUCLEI FROM MAMMALIAN TISSUES THROUGH THE USE OF TRITON X-100. J Histochem Cytochem (1964) 2.72
Cytochemical studies. IV. Physical state of certain respiratory enzymes of mitochondria. J Biol Chem (1952) 2.49
Observations on a granule associated with chromatin in the nuclei of cells of rat and mouse. J Cell Biol (1962) 2.39
STUDIES ON ISOLATED NUCLEI. I. ISOLATION AND CHEMICAL CHARACTERIZATION OF A NUCLEAR FRACTION FROM GUINEA PIG LIVER. J Cell Biol (1963) 2.38
Electron microscopic studies of detergent-treated HeLa cell nuclei. J Mol Biol (1966) 2.19
The isolation and some properties of rat liver mitochondrial deoxyribonucleic acid. Proc Natl Acad Sci U S A (1965) 1.84
Isolation and fractionation of rat brain nuclei. J Cell Biol (1966) 1.82
The isolation of cell nuclei from rat brain. J Cell Biol (1962) 1.73
Isolation and properties of liver cell nucleoli. J Biophys Biochem Cytol (1956) 1.32
STUDIES ON ISOLATED NUCLEI. II. ISOLATION AND CHEMICAL CHARACTERIZATION OF NUCLEOLAR AND NUCLEOPLASMIC SUBFRACTIONS. J Cell Biol (1963) 1.24
Isolation of liver nuclei. Nature (1960) 1.20
[Observations on the biochemical role of the nucleolus]. Biochim Biophys Acta (1954) 1.17
Enzymatic studies on isolated nucleoli of rat liver. J Biol Chem (1966) 1.13
The isolation of nucleoli from ungerminated pea embryos. J Biophys Biochem Cytol (1959) 1.09
Studies on the physiology of rat liver polyribosomes: quantition and intracellular distribution of ribosomes. Proc Natl Acad Sci U S A (1965) 1.09
[Technic for the isolation of cell nuclei based upon their density]. Bull Soc Chim Biol (Paris) (1957) 1.08
Fine structure of interphase liver cell nuclei in subacute ethionine intoxication. Exp Mol Pathol (1965) 1.06
Ultrastructural aspects of the ribonucleo-protein network in nuclei of Walker tumor and rat liver. Exp Cell Res (1967) 1.05
Isolation of skeletal muscle nuclei. J Cell Biol (1965) 1.03
Enzymology of the nucleus. Adv Enzymol Relat Areas Mol Biol (1965) 0.99
Isolation of two distinct classes of polysomes from a nuclear fraction of rat liver. J Cell Biol (1968) 0.99
Catheptic activities of the nuclei of normal, regenerating, and neoplastic tissues of the rat. J Natl Cancer Inst (1952) 0.94
Fine structure of interphase liver cell nuclei in acute ethionine intoxication. Lab Invest (1967) 0.93
Utilization of the citric acid procedure and zonal ultracentrifugation for mass isolation of nuclear RNA from Walker 256 carcinosarcoma. Cancer Res (1966) 0.93
ISOLATION OF NUCLEOLI OF THE WALKER CARCINOSARCOMA AND LIVER OF THE RAT FOLLOWING NUCLEAR DISRUPTION IN A FRENCH PRESSURE CELL. Cancer Res (1963) 0.91
A large scale procedure for isolation of nucleoli from rat liver. Exp Cell Res (1965) 0.90
Glucose-6-phosphatase in tubular endoplasmic reticulum of hepatocytes. Science (1966) 0.90
Polysomes on a nuclear membrane fraction as intermediates in the transfer of ribonucleic acid from the nucleus to the cytoplasm. Nature (1966) 0.88
AN IMPROVED METHOD FOR THE ISOLATION OF RAT LIVER NUCLEI BY DENSITY CENTRIFUGATION. J Cell Biol (1965) 0.86
Electrophoretic comparison of nuclear and nucleolar proteins. I. Beef pancreas. Biochim Biophys Acta (1961) 0.86
Ultrastructural studies on RNA and DNA components of isolated nucleoli of Walker 256 carcinosarcoma. Exp Cell Res (1966) 0.85
IN VITRO LABELING OF RNA IN ISOLATED NUCLEOLI OF THE WALKER TUMOR AND LIVER. Cancer Res (1964) 0.80
[On ultrastructure of the nucleus on the basis of electron microscopy of isolated nuclei subjected to salt extracts]. Biofizika (1963) 0.80
A large-scale procedure for isolation of nucleoli from Walker tumors. Cancer Res (1966) 0.77
Metabolism of RNA in the liver cells of the rat. I. Isolation and chemical composition of nucleus, nucleolus, chromatin, nuclear sap and cytoplasm. Exp Cell Res (1967) 0.77
A method for isolation of nuclei from cells of the Walker 256 carcinosarcoma. Cancer Res (1959) 0.77
T4 endonuclease IV. Improved purification procedure and resolution from T4 endonuclease 3. J Biol Chem (1972) 3.26
The FLP recombinase of the 2 micron circle DNA of yeast: interaction with its target sequences. Cell (1985) 2.86
Enzymatic breakage of deoxyribonucleic acid. II. Purification and properties of endonuclease IV from T4 phage-infected Escherichia coli. J Biol Chem (1969) 2.30
Enzymatic breakage of deoxyribonucleic acid. I. Purification and properties of endonuclease II from T4 phage-infected Escherichia coli. J Biol Chem (1969) 2.07
Gene 6 exonuclease of bacteriophage T7. II. Mechanism of the reaction. J Biol Chem (1972) 2.06
Studies on the Fine Structure of the Terminal Branches of the Biliary Tree: I. The Morphology of Normal Bile Canaliculi, Bile Pre-ductules (Ducts of Hering) and Bile Ductules. Am J Pathol (1961) 2.05
Mutants of bacteriophage T4 defective in the induction of T4 endonuclease II. J Biol Chem (1971) 1.77
The FLP recombinase of the Saccharomyces cerevisiae 2 microns plasmid attaches covalently to DNA via a phosphotyrosyl linkage. Mol Cell Biol (1985) 1.77
Investigations of Allergic Liver Injury: I. Light, Fluorescent and Electron Microscopic Study of the Effects of Soluble Immune Aggregates. Am J Pathol (1961) 1.66
Site-specific recombination of yeast 2-micron DNA in vitro. Proc Natl Acad Sci U S A (1983) 1.66
Bacteriophage T7 morphogenesis: phage-related particles in cells infected with wild-type and mutant T7 phage. Virology (1977) 1.59
The FLP protein of the 2-micron plasmid of yeast. Purification of the protein from Escherichia coli cells expressing the cloned FLP gene. J Biol Chem (1985) 1.59
Gene 6 exonuclease of bacteriophage T7. I. Purification and properties of the enzyme. J Biol Chem (1972) 1.58
The involvement of genes 3,4,5 and 6 in genetic recombination in bacteriophage T7. Virology (1975) 1.58
Packaging and maturation of DNA of bacteriophage T7 in vitro. Proc Natl Acad Sci U S A (1974) 1.57
Degradation of Escherichia coli B deoxyribonucleic acid after infection with deoxyribonucleic acid-defective amber mutants of bacteriophage T7. J Virol (1970) 1.53
Determination of DNA sequences essential for FLP-mediated recombination by a novel method. J Biol Chem (1985) 1.47
The fine structure of the normal, neonatal mouse liver. Lab Invest (1965) 1.36
Mutagenesis of a conserved region of the gene encoding the FLP recombinase of Saccharomyces cerevisiae. A role for arginine 191 in binding and ligation. J Mol Biol (1992) 1.31
Genetic recombination of bacteriophage T7 DNA in vitro. Proc Natl Acad Sci U S A (1976) 1.25
Studies on the Fine Structure of the Terminal Branches of the Biliary Tree: II. Observations of Pathologically Altered Bile Canaliculi. Am J Pathol (1961) 1.23
Isolation of intermediates in the binding of the FLP recombinase of the yeast plasmid 2-micron circle to its target sequence. J Mol Biol (1987) 1.22
The Cre recombinase cleaves the lox site in trans. J Biol Chem (1997) 1.22
In vitro systems for genetic recombination of the DNAs of bacteriophage T7 and yeast 2-micron circle. Cold Spring Harb Symp Quant Biol (1984) 1.21
Bacteriophage T7 endonuclease. I. Properties of the enzyme purified from T7 phage-infected Escherichia coli B. J Biol Chem (1971) 1.20
The FLP protein of the 2-micron plasmid of yeast. Inter- and intramolecular reactions. J Biol Chem (1985) 1.17
Identification of the DNA-binding domain of the FLP recombinase. J Biol Chem (1991) 1.14
FLP recombinase of the 2 microns circle plasmid of Saccharomyces cerevisiae bends its DNA target. Isolation of FLP mutants defective in DNA bending. J Mol Biol (1989) 1.13
Glycogen depletion in the newborn rat liver: an electron microscopic and electron histochemical study. J Ultrastruct Res (1967) 1.13
FLP protein of 2 mu circle plasmid of yeast induces multiple bends in the FLP recognition target site. J Mol Biol (1990) 1.09
Autoimmunization-A Possible Mechanism of Tissue Injury II. Clinical Aspects of Autoimmunity. Can Med Assoc J (1961) 1.09
Synapsis, strand scission, and strand exchange induced by the FLP recombinase: analysis with half-FRT sites. Mol Cell Biol (1991) 1.08
Ultrastructural and subcellular pathology of the liver. Int Rev Exp Pathol (1964) 1.07
Fine structure of interphase liver cell nuclei in subacute ethionine intoxication. Exp Mol Pathol (1965) 1.06
Mechanism of cleavage and ligation by FLP recombinase: classification of mutations in FLP protein by in vitro complementation analysis. Mol Cell Biol (1993) 1.06
Interaction of the FLP recombinase of the Saccharomyces cerevisiae 2 micron plasmid with mutated target sequences. Mol Cell Biol (1986) 1.06
Directional resolution of synthetic holliday structures by the Cre recombinase. J Biol Chem (2001) 1.03
Control of T4 endonuclease IV by the D2a region of bacteriophage T4. Virology (1973) 1.02
The role of DNA bending in Flp-mediated site-specific recombination. J Mol Biol (1995) 1.01
Effect of a sulfated mucopolysaccharide (R01-8307) on the zona glomerulosa of the rat adrenal gland. Endocrinology (1966) 1.00
DNA bending by Saccharomyces cerevisiae ABF1 and its proteolytic fragments. J Biol Chem (1994) 1.00
Pathways of recombination of bacteriophage T7 DNA in vitro. Cold Spring Harb Symp Quant Biol (1979) 1.00
Ligation activity of FLP recombinase. The strand ligation activity of a site-specific recombinase using an activated DNA substrate. J Biol Chem (1992) 0.99
Isolation of two distinct classes of polysomes from a nuclear fraction of rat liver. J Cell Biol (1968) 0.99
Point mutants in the D2a region of bacteriophage T4 fail to induce T4 endonuclease IV. J Virol (1974) 0.99
Homology requirements for ligation and strand exchange by the FLP recombinase. J Biol Chem (1995) 0.98
Some ultrastructural and histochemical aspects of Coxsackie virus-cell interactions. Lab Invest (1966) 0.97
Cell population dynamics in the liver. A review of quantitative morphological techniques applied to the study of physiological and pathological growth. Exp Mol Pathol (1966) 0.97
FLP site-specific recombinase of yeast 2-micron plasmid. Topological features of the reaction. J Mol Biol (1986) 0.96
Genetic recombination of bacteriophage T7 in vivo studied by use of a simple physical assay. J Virol (1981) 0.95
Synaptic intermediates promoted by the FLP recombinase. J Mol Biol (1990) 0.94
Mutations of the FLP recombinase gene that cause a deficiency in DNA bending and strand cleavage. J Biol Chem (1993) 0.94
An endodeoxyribonuclease induced after infection with phage T7 bearing amber mutations in genes 3, 5, and 6. Can J Biochem (1972) 0.94
Synthesis of an enzymatically active FLP recombinase in vitro: search for a DNA-binding domain. Mol Cell Biol (1989) 0.93
Fine structure of interphase liver cell nuclei in acute ethionine intoxication. Lab Invest (1967) 0.93
Cleavage-dependent ligation by the FLP recombinase. Characterization of a mutant FLP protein with an alteration in a catalytic amino acid. J Biol Chem (1995) 0.93
Electron microscopy of cirrhotic nodule Tubularization of the parenchyma by biliary hepatocytes. Lab Invest (1966) 0.92
Location of the ss--mutation of bacteriophage T7 in genes 10, the structural gene for the major capsid protein. J Virol (1977) 0.92
Interaction of the NH2- and COOH-terminal domains of the FLP recombinase with the FLP recognition target sequence. J Biol Chem (1994) 0.92
Identification of the functional domains of the FLP recombinase. Separation of the nonspecific and specific DNA-binding, cleavage, and ligation domains. J Biol Chem (1993) 0.91
The mechanism of loading of the FLP recombinase onto its DNA target sequence. J Mol Biol (1988) 0.91
Autoimmunization-A Possible Mechanism of Tissue Injury : III-Clinical Aspects of Autoimmunity. Can Med Assoc J (1961) 0.91
The FLP protein contacts both major and minor grooves of its recognition target sequence. Nucleic Acids Res (1992) 0.90
Career choice within medicine: a study of one graduating class at the University of Toronto. Can Med Assoc J (1969) 0.89
The liver in murine transplantation (runt) disease. Observations of the acute lesions by light and electron microscopy. Am J Pathol (1966) 0.89
The structure and maturation of intermediates in bacteriophage T7 DNA replication. Can J Biochem (1978) 0.89
Resolution of synthetic chi structures by the FLP site-specific recombinase. J Mol Biol (1993) 0.89
Attrition from general practice: career patterns of Toronto medical school graduates. J Med Educ (1977) 0.85
Resolution of immobile chi structures by the FLP recombinase of 2 microns plasmid. J Mol Biol (1994) 0.85
Trace element concentrations in the liver, kidney, and muscle of Queensland cattle. Bull Environ Contam Toxicol (1983) 0.85
Genetic recombination of bacteriophage T7 DNA in vitro. II. Further properties of the in vitro recombination-packaging reaction. Virology (1977) 0.85
In vitro recombination of bacteriophage T7 DNA detected by a direct physical assay. J Virol (1983) 0.85
Contacts of the ABF1 protein of Saccharomyces cerevisiae with a DNA binding site at MATa. J Biol Chem (1994) 0.85
Genetic recombination of bacteriophage T7 DNA in vitro. IV. Asymmetry of recombination frequencies caused by polarity of DNA packaging. Virology (1978) 0.85
Segregation of nucleolar components in mycoplasma-infected cells. Lab Invest (1967) 0.84
Autoimmunization - A Possible Mechanism of Tissue Injury I-Theoretical and Experimental Aspects. Can Med Assoc J (1961) 0.84
Chimeras of the Flp and Cre recombinases: tests of the mode of cleavage by Flp and Cre. J Mol Biol (2000) 0.84
The Flp recombinase cleaves Holliday junctions in trans. Mol Microbiol (1995) 0.83
Suppression of a mutation in gene 3 of bacteriophage T7 (T7 endonuclease I) by mutations in phage and host polynucleotide ligase. J Virol (1974) 0.81
Bacteriophage T7 defective in the gene 6 exonuclease promotes site-specific cleavages of T7 DNA in vivo and in vitro. J Virol (1982) 0.81
Selection of novel, specific single-stranded DNA sequences by Flp, a duplex-specific DNA binding protein. Nucleic Acids Res (1998) 0.79
Site-specific recombination of the yeast plasmid two-micron circle: intermediates in the binding process. Basic Life Sci (1986) 0.79
Functional analysis of the ABF1-binding sites within the Ya regions of the MATa and HMRa loci of Saccharomyces cerevisiae. Curr Genet (1995) 0.79
Asymmetry in Flp-mediated cleavage. Nucleic Acids Res (1997) 0.78
Trans complementation of variant Cre proteins for defects in cleavage and synapsis. J Biol Chem (2000) 0.78
Determinants of the position of a Flp-induced DNA bend. Nucleic Acids Res (1998) 0.78
Topological analysis of the role of homology in Flp-mediated recombination. J Biol Chem (1997) 0.77
Comparison of characteristics of male and female medical school applicants. J Med Educ (1974) 0.77
DNA sequence determinant for FIp-induced DNA bending. Mol Microbiol (1998) 0.76
An attempted simulation by computer of a committee on admissions. Can Med Assoc J (1967) 0.75
Electron microscopical studies on the liver cells in hyperplastic nodules of human cirrhosis. Rev Int Hepatol (1966) 0.75
Career choices of entering university students. J Med Educ (1978) 0.75
Research Expenditures and Medical Practice. Can Med Assoc J (1963) 0.75
An evaluation of the Dial Access Cancer Education System in Illinois. IMJ Ill Med J (1980) 0.75
An empirical definition of a medical school's admissions procedures. J Med Educ (1974) 0.75
A propos of the "presence of virus-like bodies in liver cells of patients with infectious hepatitis". J Clin Pathol (1967) 0.75
In vitro concatemerization of bacteriophage T7 DNA: role of DNA synthesis and gene 6 exonuclease. Can J Biochem Cell Biol (1985) 0.75
The role of single-stranded DNA in Flp-mediated strand exchange. J Biol Chem (1998) 0.75
The clinical services manager: a curriculum for the 21st century. Clin Lab Manage Rev (1998) 0.75
[Not Available]. Can Med Assoc J (1963) 0.75